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Indian J Med Microbiol ; 2011 Oct-Dec; 29(4): 414-417
Article Dans Anglais | IMSEAR | ID: sea-143867

Résumé

Complement-dependent lymphocytotoxicity crossmatches (n=217) between 47 deceased donors and 150 potential renal recipients were retrospectively studied. A negative cross match was reported in 48 (22.1%), doubtful positive in 126 (58.1%), weakly positive in 32 (14.7%) and positive in 11 (5.1%). No autoantibodies were detected. Renal transplantation was performed in 35.5% of the potential recipients. There was no incidence of hyperacute rejection. The graft survival rate was 88% at 15 months of follow up. The study concludes that a negative pretransplant lympocytotoxicity crossmatch using the basic National Institute of Health technique eliminates hyperacute rejection, but carries drawbacks, which require modification and supplementation with more sensitive and specific assays.


Sujets)
Adolescent , Adulte , Sujet âgé , Enfant , Enfant d'âge préscolaire , Protéines du système du complément/immunologie , Tests de cytotoxicité immunologique/méthodes , Femelle , Rejet du greffon/immunologie , Survie du greffon/immunologie , Test d'histocompatibilité/méthodes , Humains , Transplantation rénale/immunologie , Mâle , Adulte d'âge moyen , Études rétrospectives , Résultat thérapeutique , Jeune adulte
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