relationship between helicobacter pylon infection and childhood idiopathic thrombocytopenic purpura

Idiopathic thrombocytopenic purpura, a disorder characterized by autoantibody mediated platelets destruction causing decreased number of circulating platelets manifest as bleeding tendency. Since the discovery of Helicobacter pylon [H. pylon] several studies have been published concerning a hypothetical role of this bacteria in idiopathic thrombocytopenic purpura. Evaluate the pathogenic correlation between H. pylori infection and idiopathic thrombocytopenic purpura. A cross sectional study was done on 30 cases of idiopathic thrombocytopenic purpura admitted to the Pediatric Hemato-Oncology unit in ALKadhimiyia Teaching Hospital and 20 cases of sex and age matched healthy children asa control io determine the relation between H. pylon infection and idiopathic thrombocytopenic purpura. The peak age for idiopathic thrombocytopenic purpura was between [6-10 years] of age, [43.33%]. Male: female ratio equal to 2:1. ELIZA test was used to measure the serum IgG antibody titer against H. pylon, 5 cases of idiopathic thrombocytopenic purpura was found to be positive for H.pylori [16.67%]while the test was negative in all of the control group [100%] a result which is statistically highly significant, p - value < 0. 05. Of the positive cases 3 [60%] was chronic idiopathic thrombocytopenic purpura and two cases [40%] was acute idiopathic thrombocytopenic purpura. Patients with positive test were older than those with negative test. The mean platelet count was less in the positive than those with negative test. A weak inverse correlation was found between platelet count and H. pylori serum antibody titer [r- value equal to -0.13437]. The test was sensitive in [20%] and speicific in [100%] of cases H. pylori infection may play a role in the initiation of idiopathic thrombocytopenic purpura and eradication of H. pylori infection can cure idiopathic thrombocytopenic purpura specially in chronic and resistant cases. The ELIZA test can be used as a screening test to detect H.pylori infection in children with idiopathic thrombocytopenic purpura

Childhood idiopathic thrombocytopenic purpura: a retrospective analysis of clinical features and response to treatment

A retrospective study was done in the Pediatric ward /AL-Kadhimiyia Teaching Hospital on cases diagnosed as idiopathic thrombocytopenic Purpura admitted since the first of January 1992 - the end of December 2004. The objective of this paper is to review the natural history of idiopathic thrombocytopenic Purpura, presenting feature and response to treatment. The review included age, sex, clinical presentation, physical finding, complications, investigation treatment and course of the diseases. Total number of the patients were 65, peak age was between [2 -5] years, 40 cases [61.53%]. Females were affected more than Males with male: female ratio of I: 2.09 .There was no seasonal variation and all of the cases were preceded by viral upper respiratory tract infection. The main presentation was petechiae and ecchymosis, were found in all of them [100%] followed by epistaxis, 43 cases [66.15%]. In the majority the platelet count was < 20.000 X 10[9] /L, 32 cases [49.23%] and the hemoglobin level was between 10-11 gm /dl in most of them, 43 cases [66.15%]. Steroid was the first line treatment, response occur within 2-3 weeks in the majority, 51 cases [78.46%]. Chronic idiopathic thrombocytopenic Purpura occurred in 3 cases only [4.61%]. Splenectomy was done in 2 of them [66.66%]. No mortality detected. Idiopathic thrombocytopenic purpura is a mild disease with complete recovery in the majority of patients

Thromboembolic events in S-ThaSassemia major patients

Seventy eight patients with beta - thalassemia major were Collected randomly from the thalassemia center in Ibn-Al-Baldy Hospital [all of them were transfusion dependent], together with fifty six age and sex matched healthy children were collected as a control. To determine the incidence ofthromboembolism among them and to evaluate the precipitating factors. History was taken and physical examination was done. EDTA Anticoagulated blood samples were taken prior to the next transfusion, platelet parameters were estimated for both groups using the MS - 9 coulter counter. Thromboembolic events was detected in five patients [6.41%]. The main site was the central nervous system in 4 of them [5.2%] followed by the lung J case [1.2%]. Associated predisposing factors were found in 3 of them [60%]. The patients had a statistically significant higher platelet counts, platelet crit, mean platelet volume and platelet distribution width than the control group. The splenectombed had higher platelet counts. platelet crit than the non splenectomizedwith nearly equal mean platelet volume and platelet distribution width, a results that is in favour of thrombosis. This results suggest that beta- thalassemia patients had a hypercoagulable state which makes them susceptible to thrombosis and pulmonary embolism even in the young age group and even before splenectomy is performed

Glucose 6 phosphate dehydrogenase deficiency in a group of iraqi children

Glucose 6 phosphate deosphate dehydnogenase [G6PD] deficiency is a common problem in Iraqi as well as in tropical and subtropical region.To study the epidemiological aspect of G6PD defiaiencv among Iraqi children.This cross sectional study was conducted in the Pediatric ward/AL Kadhiymia Teaching Hospital during the season of Fava beans ingestion. Patients who were presented with acute attack of pallor were collected, history was taken and physical examination was done.Ninety seven cases were studied, males were affected more than female with a ratio of 3.85:1, the peak of age was between [1-5years], 76 cases ,[78.35%].Previous history of neonatal jaundice was found in 24 cases [24.74%], the acute hemolytic attack was precipitated by Fava beans ingestion in all of the cases [100%] and pallor was the main presenting feature in all of them. The attack was very severe in 43 cases [44.32%] with arrange of PCV between [1 - 9%]. History of recurrence was encountered in 11 cases [11.34%], family history of G6PD deficiency was found in 22 cases [22.68%] .G6PD level was estimated two months later in 31 cases [31.95%] only and were found to be deficient