possible hypoglycemic and antioxidant effect of herbal mixture extraction in diabetic rats

The use of medicinal plants for management of diabetes mellitus is an old practice which has become even more relevant in modern perspective. The present work was designed to evaluate the effect of a mixture of five medicinal plants which used in folk medicine in Egypt especially in Sinai as hypoglycemic agents on the adult male diabetic rats. These plants are Cleome droserifolia [Samwah], Ambrosia maritima [Damsissa],Artemisia judaica [Shih kharasani], Chiliadenus montanus or Jasonia Montana [Neheda] and Artemisia annua [Kaysom]. Thirty male albino rats were divided equally into three groups including control, diabetic and diabetic treated with a mixture of aqueous extract. A single dose of alloxan [120 mg/kg body weight] was used to induce diabetes in rats. Diabetic rats were given plant mixture extract orally twice daily for 30 days [28.5 mg/kg body weight [b. wt.] twice/day]. There was a marked decline [p<0.01] in levels of serum insulin, body weight [4.98 %], total proteins, albumin, globulin and high density lipoproteins [HDL] accompanied with marked elevation [p<0.01] in levels of fasting blood glucose, homeostasis model assessment of insulin resistance [HOMA_IR], aspartate aminotransferase[ASAT], alanine aminotransferase [ALAT], gamma-glutamyltransferase [GGT], urea, creatinine, uric acid, serum total lipids[TL], total cholesterol [TC], triglycerides TG, low density lipoproteins [LDL], and very low density lipoproteins[VLDL],risk ratios of TC/HDL and LDL/HDL in diabetic rats as compared to the control rats. While administration of aqueous extract of plant mixture to alloxan diabetic rats significantly ameliorated the disturbed biochemical parameters. These results proved that this plant mixture extract has a significant hypoglycemic effect and ameliorating metabolic abnormalities induced by diabetes mellitus

effects of Jasonia montana [neheda] on some biochemical and histological parameters of diabetic albino rats

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. In Asia, different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Jasonia montana [Neheda] was one of these plants that was used in a mixture to treat diabetic patients long times ago. This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of Jasonia montana [Neheda] on the alloxan-induced diabetic male albino rats. This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups [10 /cage]; Group I [Control untreated group], Group II [Alloxan-induced diabetic group] and Group III [diabetic group treated orally with "28.5 mg/ kg body wt. twice/ day" of the plant extract]. The biochemical results showed marked decline [p<0.01] in levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation [p<0.001] in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL [risk factors] in diabetic rats in comparison with the control group. Daily management of diabetic rates with aqueous extract of Neheda showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Neheda in liver, kidney and pancreatic tissues in comparison to the control group. It could be concluded that Jasonia montana [Neheda] can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes

effects of Ambrosia maritime L. [damsissa] on some biochemical and histological parameters of diabetic albino rats

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. Different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Ambrosia maritima, L. [Damsissa] which is one of these plants that its extract was used to treat diabetic patients long times ago. This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of Ambrosia maritima, L. [Damsissa] on the alloxan-induced diabetic male albino rats. This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups [10 /cage]; Group I [Control untreated-group], Group II [Alloxan-induced diabetic group] and Group III [diabetic group treated orally with "28.5 mg/ kg body wt. twice/ day" of the plant extract]. The biochemical results showed marked decline [p<0.01] in the levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation [p<0.001] in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL [risk factors] in diabetic rats in comparison with the control group. Daily management of the diabetic rates with aqueous extract of Damsissa showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Damsissa in liver, kidney and pancreatic tissues in comparison to the control group. It could be concluded that Ambrosia maritima, L. [Damsissa] can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes