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1.
Braz. j. med. biol. res ; 30(8): 967-70, Aug. 1997. tab
Article Dans Anglais | LILACS | ID: lil-197253

Résumé

Male Wistar rats were trained in one-trial step-down inhibitory avoidance using a 0.4-mA footshock. At various times after training (0, 1.5, 3,6 and 9 h for the animals implanted into the CA1 region of the hippocampus; 0 and 3 h for those implanted into the amygdala), these animals received microinfusions of SKF38393 (7.5 mug/side), SCH23390 (0.5 mug/side), norepinephrine (0.3 mug/side), timolol (0.3 mug/side), 8-OH-DPAT (2.5 mug/side), NAN-190 (2.5 mug/side), forskolin (0.5 mug/side), KT5720 (0.5 mug/side) or 8-Br-cAMP (1.25 mug/side). Rats were tested for retention 24 h after training. When given into the hippocampus 0 h post-training, norepinephrine enhanced memory whereas KT5720 was amnestic. When given 1.5 h after training, all treatments were ineffective. When given 3 or 6 h post-training, 8-Br-cAMP, forskolin, SKF38393, norepinephrine and NAN-190 caused memory facilitation, while KT5720, SCH23390, timolol and 8-OH-DPAT caused retrograde amnesia. Again, at 9 h after training, all treatments were inffective. When given into the amygdala, norepinephrine caused retrograde facilitation at 0 h after training. The other drugs infused into the amygdala did not cause any significant effect. These data suggest that in the hippocampus, but not in the amygdala, a cAMP/protein kinase A pathway is involved in memory cosolidation at 3 and 6 h after training, which is regulated by D1, Beta, and 5HT1A receptors. This correlates with data on increased post-training cAMP levels and a dual peak of protein kinase A activity and CREB-P levels (at 0 and 3-6 h) in rat hippocampus after training in this task. These results suggest that the hippocampus, but not the amygdala, is involved in long-term storage of step-down inhibitory avoidance in the rat.


Sujets)
Rats , Animaux , Mâle , Amygdale (système limbique)/effets des médicaments et des substances chimiques , Cyclic AMP-Dependent Protein Kinases/effets des médicaments et des substances chimiques , AMP cyclique/analyse , Hippocampe/effets des médicaments et des substances chimiques , Mémoire/physiologie , 8-Bromo AMP cyclique/pharmacologie , 7-Dipropylamino-5,6,7,8-tétrahydro-1-naphtol/pharmacologie , Benzazépines/pharmacologie , Colforsine/pharmacologie , Protéine de liaison à l'élément de réponse à l'AMP cyclique/analyse , Norépinéphrine/pharmacologie , Rat Wistar , Transduction du signal
2.
Braz. j. med. biol. res ; 30(2): 235-40, Feb. 1997. ilus, graf
Article Dans Anglais | LILACS | ID: lil-188432

Résumé

A total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a stepdown inhibitory avoidance task. At various times after training (0, 30, 60 or 90 min) the animals received a 0.5-mul microinfusion of vehicle (saline) or O.5 mug of muscimol dissolved in the vehicle. A retention test was carried out 24 h after training. Retention test performance was hindered by muscimol administered into both the hippocampus and amygdala at 0 but not at 30 min posttraining. The drug was amnestic when given into the entorhinal cortex 30, 60 or 90 min after training, or into the parietal cortex 60 or 90 min after training, but not before. These findings suggest a sequential entry in operation, during the posttraining period, of the hippocampus and amygdala, the entorhinal cortex, and the posterior parietal cortex in memory processing.


Sujets)
Rats , Mâle , Animaux , Amygdale (système limbique)/physiologie , Cortex entorhinal/physiologie , Hippocampe/physiologie , Mémoire/physiologie , Muscimol/pharmacologie , Lobe pariétal/physiologie , Amygdale (système limbique)/effets des médicaments et des substances chimiques , Cortex entorhinal/effets des médicaments et des substances chimiques , Hippocampe/effets des médicaments et des substances chimiques , Lobe pariétal/effets des médicaments et des substances chimiques , Rat Wistar
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