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1.
Asian Pac J Allergy Immunol ; 1991 Dec; 9(2): 107-19
Article Dans Anglais | IMSEAR | ID: sea-37199

Résumé

To examine the immunopathogenesis of type 2 erythema nodosum leprosum (ENL) reactions in leprosy, we studied cellular and soluble immunologic components of skin lesions in 57 patients with reactions (19 acute ENL and 38 chronic ENL), 61 active patients without reactions, and 33 control patients whose leprosy had been treated and cured. Cells, IgM antibody to PGL-1 and Tac peptide levels were obtained from fluid aspirated from blisters induced by suction directly over representative skin lesions. During ENL reactions: a) the lesions in chronic ENL showed a decreased number of CD8+ (T-suppressor) cells and increased helper/suppressor ratio as compared to those in acute ENL and non-reactional leprosy; b) Tac peptide and IgM antibody to PGL-1 levels were elevated in the chronic ENL lesions; c) and systemic administration of corticosteroids appeared to cause a reduction in the intralesional CD4+ cell population and IgM antibody to PGL-1 but did not change CD8+ cell population and the levels of Tac peptide in the lesions. The elevated levels of Tac peptide were localized in the skin lesions while increased levels of IgM anti-PGL-1 seemed to be filtered from the peripheral blood. We conclude that spontaneous lymphocyte activation in situ, primarily of decreased CD8+ and relatively increased CD4+ cells, are important features of chronic, recurrent ENL reactions and may be an intermittent or cyclic phenomenon during the reaction. Understanding the mechanisms of these spontaneous changes in immunity in leprosy will enlarge our knowledge of reactions and of the underlying determinants of delayed type hypersensitivity and cell-mediated immunity in leprosy, which in turn will allow us to realize the potential for artificially manipulating these responses as proposed with vaccines or immunotherapy.


Sujets)
Adolescent , Adulte , Sujet âgé , Antigènes bactériens/analyse , Cloque/immunologie , Rapport CD4-CD8 , Numération cellulaire , Maladie chronique , Érythème noueux/immunologie , Femelle , Glycolipides/immunologie , Humains , Immunoglobuline M/analyse , Lèpre lépromateuse/immunologie , Mâle , Adulte d'âge moyen , Mycobacterium leprae/immunologie , Récepteurs à l'interleukine-2/immunologie
2.
Article Dans Anglais | IMSEAR | ID: sea-44727

Résumé

The cellular contents and soluble interleukin-2 receptor (IL-2R) [Tac peptide] of skin blisters induced by suction over 7 reversal reaction (RR) patients were examined using immunoperoxidase and ELISA techniques respectively. The helper T activity (CD4+ cells) and helper:suppressor ratio were significantly greater in borderline lepromatous (BL) lesions with RR than in quiescent BL lesions. Interestingly, the intracutaneous levels of Tac peptide were elevated and directly correlated with the increases in CD4+ cells. The systemic administration of corticosteroids revealed a reduction in the numbers of CD4+ cells in the lesions. These results indicate that RRs are manifestations of a spontaneous increase in delayed type hypersensitivity (DTH) and possibly cell mediated immunity (CMI) in leprosy patients. The mechanism of such changes in immunity is of considerable value in understanding reversal reactions and the underlying determinants of DTH and CMI in leprosy and this in turn will have a bearing on the potential for proposed vaccines or immunotherapy.


Sujets)
Adulte , Cloque/immunologie , Femelle , Humains , Lèpre/immunologie , Numération des leucocytes , Mâle , Adulte d'âge moyen , Récepteurs à l'interleukine-2/analyse , Reproductibilité des résultats , Lymphocytes T/immunologie
3.
Asian Pac J Allergy Immunol ; 1989 Dec; 7(2): 89-93
Article Dans Anglais | IMSEAR | ID: sea-36460

Résumé

It remains uncertain whether the cellular immune abnormalities of patients with lepromatous leprosy interfere with resolution of hepatitis B virus (HBV) infections. To investigate this question in an area coendemic for the two diseases, we determined the prevalence of hepatitis B surface antigen (HBsAg) and antibody (anti-HBs) in: 1) 204 leprosy patients living in three leprosy resettlement villages; 2) 198 contacts living in the same villages; and 3) 44 newly diagnosed leprosy patients in Thailand. Within the villages, the prevalence of HBsAg positivity was inversely related to age, tended to be more frequent in patients with tuberculoid than lepromatous leprosy, and was similar after age adjustment among persons with and without leprosy. The prevalence of HBV markers found in newly diagnosed patients was similar to that in the villagers. We conclude that extensive HBV transmission had occurred in the resettlement villages and that the natural history of HBV infection was similar in persons with, whether tuberculoid or lepromatous, and without leprosy.


Sujets)
Adolescent , Adulte , Facteurs âges , Enfant , Enfant d'âge préscolaire , Hépatite B/épidémiologie , Anticorps de l'hépatite B/immunologie , Antigènes de surface du virus de l'hépatite B/immunologie , Humains , Nourrisson , Lèpre lépromateuse/épidémiologie , Lèpre tuberculoïde/épidémiologie , Adulte d'âge moyen , Thaïlande/épidémiologie
5.
Southeast Asian J Trop Med Public Health ; 1986 Mar; 17(1): 104-10
Article Dans Anglais | IMSEAR | ID: sea-33403

Résumé

The lymphocyte hyporesponsiveness to M. leprae of patients with active lepromatous leprosy has been well described. This immune defect is less well understood in terms of its time of origin, possible reversibility and specificity. To further examine the persistence and specificity of this abnormality, lymphocyte transformation tests of 93 leprosy patients to lepromin, BCG and PHA were studied. Among lepromatous patients, a decreased response to M. leprae was seen, whether the disease was active or inactive. Decreased responses to BCG were found in lepromatous patients with active disease, but not in those with inactive disease. The duration of patient symptoms was not associated with differences in LTT responses among the active lepromatous patients.


Sujets)
Adolescent , Adulte , Vaccin BCG/pharmacologie , Humains , Lépromine , Lèpre/immunologie , Activation des lymphocytes , Mâle , Adulte d'âge moyen , Phytohémagglutinine/pharmacologie
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