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1.
Journal of Rheumatic Diseases ; : 242-246, 2021.
Article Dans Anglais | WPRIM | ID: wpr-892884

Résumé

Mixed cryoglobulinemic vasculitis (CV) is occasionally caused by autoimmune diseases including systemic sclerosis. Multiorgan involvement such as skin, kidney, and peripheral nerve involvement is common in mixed CV. However, central nervous system (CNS) involvement is extremely rare. Here, we report a case of overlap syndrome of limited cutaneous systemic sclerosis and mixed cryoglobulinemic vasculitis with CNS involvement. The neurologic deficits and systemic symptoms improved promptly after steroid and cyclophosphamide therapy.

2.
Journal of Rheumatic Diseases ; : 242-246, 2021.
Article Dans Anglais | WPRIM | ID: wpr-900588

Résumé

Mixed cryoglobulinemic vasculitis (CV) is occasionally caused by autoimmune diseases including systemic sclerosis. Multiorgan involvement such as skin, kidney, and peripheral nerve involvement is common in mixed CV. However, central nervous system (CNS) involvement is extremely rare. Here, we report a case of overlap syndrome of limited cutaneous systemic sclerosis and mixed cryoglobulinemic vasculitis with CNS involvement. The neurologic deficits and systemic symptoms improved promptly after steroid and cyclophosphamide therapy.

3.
Annals of Dermatology ; : S127-S130, 2011.
Article Dans Anglais | WPRIM | ID: wpr-23486

Résumé

Congenital syphilis occurs when Treponema pallidum crosses the placenta during pregnancy or from contact with an infectious genital lesion during delivery. Cutaneous manifestations of congenital syphilis are relatively common, occurring in approximately 30% to 70% of patients. Maculopapular lesions, vesiculobullous lesions, condylomata lata lesions, annular lesions, and erythema multiforme-like targetoid lesions have been reported. We report on a premature newborn with congenital syphilis who presented with generalized bullous and pustular eruption and desquamation at birth.


Sujets)
Humains , Nouveau-né , Grossesse , Cloque , Érythème , Parturition , Placenta , Syphilis , Syphilis congénitale , Treponema pallidum
4.
Korean Journal of Dermatology ; : 86-89, 2011.
Article Dans Coréen | WPRIM | ID: wpr-171977

Résumé

Neutrophilic dermatosis of the dorsal hands (NDDH) is a rare, localized variant of Sweet syndrome, and it was first described by Galaria et al. in 2000. It usually occurs in middle-aged women and it is characterized by erythematous papules, plaques, pustules and hemorrhagic bullae that are generally located on the dorsal hands. The histopathological findings show prominent papillary dermal edema and a dense dermal neutrophilic infiltration. A neutrophilic infiltrate can also cause a variable degree of vascular damage: endothelial cell swelling, RBC extravasation, leukocytoclasia and fibrin deposition within the walls of vessels. We report here on a case of NDDH in a 50-year-old man who was treated with oral corticosteroid and the NDDH recurred after 9 months.


Sujets)
Femelle , Humains , Adulte d'âge moyen , Cloque , Oedème , Cellules endothéliales , Fibrine , Main , Granulocytes neutrophiles , Maladies de la peau , Syndrome de Sweet
5.
Annals of Dermatology ; : S322-S325, 2011.
Article Dans Anglais | WPRIM | ID: wpr-165620

Résumé

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is an uncommon, benign dermatosis and is characterized by asymptomatic grouped keratotic papules and plaques with a linear pattern on the extremities. Various treatments, including topical steroids, topical calcipotriol, topical 5-fluorouracil, retinoid, cryotherapy, and carbon dioxide laser ablation have been tried for PEODDN, but the results were unsatisfactory. Recently, topical photodynamic therapy (PDT) has been shown to be effective for various cutaneous disorders. We report a case of PEODDN showing partial remission with PDT using topical 5-aminolevulanic acid in a 4-year-old girl.


Sujets)
Calcitriol , Cryothérapie , Membres , Fluorouracil , Lasers à gaz , Naevus , Photothérapie dynamique , Enfant d'âge préscolaire , Maladies de la peau , Stéroïdes , Triazènes
6.
Korean Journal of Dermatology ; : 826-829, 2011.
Article Dans Coréen | WPRIM | ID: wpr-82914

Résumé

Lichen sclerosus et atrophicus (LSA) is a benign, chronic inflammatory mucocutaneous disease of unknown etiology with a predilection for the female genital area, which is highly bothersome. It may also involve other areas, mainly the upper trunk, axillae and buttocks and clinicians often make a misdiagnosis of these extragenital lesions due to their rarity and lack of symptoms. We herein report the case of a 69-year-old female patient with multiple extragenital LSA presenting with hemorrhagic change. Histopathologic evaluation showed follicular plugging, atrophy of stratum malpighii with hydropic degeneration of basal cells, prominent upper dermal edema and lichenoid lymphocytic infiltration in the mid dermis which was consistent with LSA. We remind clinicians of including LSA in the differential diagnoses of multiple cutaneous hemorrhagic lesions.


Sujets)
Sujet âgé , Femelle , Humains , Atrophie , Aisselle , Fesses , Derme , Diagnostic différentiel , Erreurs de diagnostic , Oedème , Hémorragie , Lichen scléroatrophique , Lichens
7.
Korean Journal of Dermatology ; : 445-448, 2010.
Article Dans Coréen | WPRIM | ID: wpr-216981

Résumé

Pachydermoperiostosis is a very rare genodermatosis that is characterized by pachydermia, digital clubbing and periostosis. It usually occurs during adolescence and the disease is inherited in an autosomal dominant manner. Although the pathogenesis of this disease is still a matter of debate, it is associated with abnormal proliferation of fibroblasts, osteoblasts and endothelial cells and altered proteoglycan synthesis. We report here on a case of pachydermoperiostosis in a 21-year-old man who was diagnosed by the clinical features, skin biopsy and radiological examinations.


Sujets)
Adolescent , Humains , Jeune adulte , Biopsie , Cellules endothéliales , Fibroblastes , Pachydermopériostose , Ostéoblastes , Protéoglycanes , Peau
8.
Korean Journal of Dermatology ; : 844-852, 2010.
Article Dans Coréen | WPRIM | ID: wpr-63109

Résumé

BACKGROUND: Syphilis is an infection caused by Treponema pallidum (T. pallidum), and this disease is increasing in incidence. However, making the diagnosis of syphilis is sometimes still challenging because of the variable clinical and histopathologic findings and there are cases with negative serologic findings, and especially in the setting of HIV infection and immunosuppressive therapy. OBJECTIVE: In this study, we specifically evaluated the number and distribution patterns of T. pallidum in the skin lesions from patients with primary or secondary syphilis. METHODS: orty eight skin biopsy specimens with the clinical and/or serological diagnosis of syphilis were evaluated by immunohistochemistry (IHC) using primary polyclonal antibodies against T. pallidum. RESULTS: Overall, T. pallidum was identified in 45 specimens (94%). The IHC of the 22 specimens from the patients with primary syphilis were all positive (100%). Twenty three (88%) out of 26 specimens from the patients with secondary syphilis showed positive results. T. pallidum was also identified in three patients with negative VDRL. Although the density of T. pallidum was higher in the specimens from the patients with primary syphilis than in those from the patients with secondary syphilis, the differences were not statistically significant (p=0.32). An epitheliotropic pattern was more frequently observed in the specimens from the patients with secondary syphilis (81%) than in those from the patients with primary syphilis (50%) (p=0.01). The density and distribution patterns of T. pallidum didn't show any correlation with the duration of skin lesions or the VDRL titer. CONCLUSION: IHC using a polyclonal antibody against T. pallidum could be an effective method for making the diagnosis of primary and secondary syphilis.


Sujets)
Humains , Anticorps , Biopsie , Infections à VIH , Immunohistochimie , Incidence , Peau , Syphilis , Treponema , Treponema pallidum
9.
Korean Journal of Dermatology ; : 810-813, 2010.
Article Dans Coréen | WPRIM | ID: wpr-191886

Résumé

Dermatofibroma is a common benign fibrohistiocytic tumor that mainly presents as a brown papule or nodule. However, it can sometimes present with diverse clinical forms such as a cyst. Combined dermatofibroma is defined as a tumor that comprises two or more variants of dermatofibroma in a single lesion. We herein report on a case of combined dermatofibroma in a 40-year-old woman who presented with a cyst form on her lateral neck. The histological findings included the combined features of the aneurysmal and atypical variants of dermatofibroma such as cleft-like spaces with hemorrhage, some pleomorphic cells and multinucleated giant cells, as well as a feature of typical dermatofibroma.


Sujets)
Adulte , Femelle , Humains , Anévrysme , Cellules géantes , Hémorragie , Histiocytome fibreux bénin , Cou
10.
Korean Journal of Dermatology ; : 1300-1303, 2009.
Article Dans Coréen | WPRIM | ID: wpr-40327

Résumé

Dermatofibromas are common benign fibrohistiocytic tumors that occur primarily as a solitary lesion, while multiple eruptive dermatofibromas (MEDFs) are a rare presentation of dermatofibromas and MEDFs are frequently associated with altered immunity, such as autoimmune diseases and immunosuppression. It is still unclear why MEDFs occur in association with these conditions, but this relationship may suggest that MEDFs are the result of an abortive immunoreactive process. We herein report on a case of MEDF that developed in a patient who was diagnosed with systemic lupus erythematosus.


Sujets)
Humains , Maladies auto-immunes , Histiocytome fibreux bénin , Immunosuppression thérapeutique , Lupus érythémateux disséminé
11.
Annals of Dermatology ; : 443-446, 2009.
Article Dans Anglais | WPRIM | ID: wpr-43541

Résumé

Tuberculosis cutis orificialis (TCO) is a rare manifestation of cutaneous tuberculosis that is caused by auto-inoculation of mycobacteria in patients with advanced internal tuberculosis. TCO occurs in oral, perianal, or genital mucosa and adjacent skin. The tongue is the most frequently affected site, but the perianal area can also be affected. A 39-year-old male presented with a 4-month history of painful ulcers on the perianal area. The histopathologic findings revealed granulomatous infiltrates composed of epithelioid cells and Langhans-type giant cells in the dermis, and a few acid-fast bacilli noted on Ziehl-Neelsen staining. The polymerase chain reaction (PCR) was positive for Mycobacterium tuberculosis and the chest X-ray showed findings consistent with active pulmonary tuberculosis in both upper lung zones. The skin lesion showed complete resolution 2 months after the start of treatment with antituberculosis agents. We report a case of TCO with perianal involvement in a patient with underlying active pulmonary tuberculosis.


Sujets)
Adulte , Humains , Mâle , Derme , Cellules épithélioïdes , Cellules géantes de Langhans , Poumon , Muqueuse , Mycobacterium tuberculosis , Réaction de polymérisation en chaîne , Peau , Thorax , Langue , Tuberculose , Tuberculose cutanée , Tuberculose pulmonaire , Ulcère
12.
Journal of Korean Medical Science ; : 548-554, 2005.
Article Dans Anglais | WPRIM | ID: wpr-147628

Résumé

Intestinal epithelial cells (IECs) have been known to produce galactose-alpha1,4-galactose-beta1,4-glucose ceramide (Gb3) that play an important role in the mucosal immune response. The regulation of Gb3 is important to prevent tissue damage causing shiga like toxin. Epigallocatechin-3-gallate (EGCG) has been studied as anti-carcinogenic, anti-oxidant, anti-angiogenic, and anti-viral activities, and anti-diabetic. However, little is known between the expressions of Gb3 on IECs. The aim of this study was to examine the inhibitory effect of EGCG, a major ingredient of green tea, on Gb3 production via mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-kappa B) in the TNF-alpha stimulated human colon epithelial cells, HT29. To investigate how Gb3 is regulated, ceramide glucosyltransferase (CGT), lactosylceramide synthase (GalT2), and Gb3 synthase (GalT6) were analyzed by RT-PCR in HT 29 cells exposed to TNF-alpha in the presence or absence of EGCG. EGCG dose-dependently manner, inhibits TNF-alpha induced Gb3 expression by blocking in both the MAPKs and NF-kappaB pathways in HT29 cells. TNF-alpha enhanced CGT, GalT2 and GalT6 mRNA levels and EGCG suppressed the level of these enzymes enhanced by TNF-alpha treatment.


Sujets)
Humains , Apoptose/effets des médicaments et des substances chimiques , Technique de Western , Catéchine/analogues et dérivés , Noyau de la cellule/effets des médicaments et des substances chimiques , Prolifération cellulaire/effets des médicaments et des substances chimiques , Relation dose-effet des médicaments , Cellules épithéliales/effets des médicaments et des substances chimiques , Cytométrie en flux , Galactosyltransferases/génétique , Régulation de l'expression des gènes codant pour des enzymes/effets des médicaments et des substances chimiques , Glucosyltransferases/génétique , Cellules HT29 , Muqueuse intestinale/effets des médicaments et des substances chimiques , Mitogen-Activated Protein Kinases/antagonistes et inhibiteurs , Facteur de transcription NF-kappa B/antagonistes et inhibiteurs , Phosphorylation/effets des médicaments et des substances chimiques , Transport des protéines/effets des médicaments et des substances chimiques , ARN messager/génétique , RT-PCR , Trihexosylcéramide/biosynthèse , Facteur de nécrose tumorale alpha/pharmacologie
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