Résumé
Background: Acromegaly is associated with increased morbidity and mortality relatedto cardiovascular diseases. Leptin [LEP] and Leptin Receptor [LEPR] gene polymorphismscan increase cardiovascular risks. The aim of this study was to investigateassociation between the frequencies of LEP and LEPR gene polymorphisms and subclinicalatherosclerosis in acromegalic patients
Methods: Forty-four acromegalic patients and 30 controls were admitted to study.The polymorphisms were identified by using polymerase chain reaction from peripheralblood samples. The levels of systolic and diastolic blood pressure, BMI, fastingplasma glucose, fasting insulin, IGF-I, GH, IGFBP3, leptin, triglyceride, carotid IntimaMedia Thickness [cIMT] and HDL and LDL cholesterol concentrations were evaluated
Results: There was statistically significant difference between the LEPR genotypes ofacromegalic patients [GG 11.4%, GA 52.3%, and AA 36.4%] and controls [GG 33.3%,GA 50%, and AA 16.7%] although their LEP genotype distribution was similar. In addition,the prevalence of the LEPR gene G and A alleles was significantly different betweenpatients and controls. No significant difference was found among the G[-2548]A leptin genotypes of groups in terms of the clinical parameters. cIMT significantly increasedhomozygote LEPR GG genotype group compared to AA subjects in patients.But the other parameters were not different between LEPR genotypes groups of patientsand controls
Conclusion: It can be said that the LEPR gene polymorphism may affect cIMT in patients.The reason is that LEPR GG genotype carriers may have more risk than othergenotypes in the development of subclinical atherosclerosis in acromegaly
Résumé
Objective: To determine the relationship between central adiposity parameters and autonomic nervous system [ANS] dysfunction
Subjects and Methods: The study included 114 obese individuals without any cardiovascular risk factors. Weight [in kg], height [in m], and waist circumference [WC; in cm] were measured and body mass index was calculated. Echocardiographic examination was performed to measure left ventricular mass and epicardial fat thickness [EFT]. All the participants underwent an exercise test and electrophysiological evaluation using electromyography. Heart rate recovery [HRR] at 1-5 min, R-R interval variation at rest and during hyperventilation, and sympathetic skin response were measured. Pearson's correlation analysis was used. Multiple linear regression analysis was used to identify the factors associated with autonomic dysfunction
Results: The HRR at 1-5 min was negatively correlated with WC and age [WC-HRR1: r = -0.32; WC-HRR2: r = -0.31; WC-HRR3: r = -0.26; WC-HRR4: r = -0.23; WC-HRR5: r = -0.21; age-HRR2: r = -0.32; age-HRR3: r = -0.28; age-HRR4: r = -0.41; age-HRR5: r = -0.42]. Age was the only independent predictor of reduced HRR at 1-5 min. In addition, WC predicted a reduced HRR at 3 min. There were no significant associations between central obesity and electrophysiological parameters. EFT was not associated with ANS dysfunction
Conclusion: In this study, central adiposity and aging were associated with ANS dysfunction in obese individuals. The WC could be a marker of ANS dysfunction in obese individuals without any cardiovascular risk factors. The HRR assessment at a later decay phase could be more valuable for evaluating ANS function than during early recovery