Résumé
Pulmonary cryptococcosis is a non-infectious opportunistic or silent infection caused by Cryptococcus neoformans. It enters the body through the respiratory tract and spreads to lung, skin, liver, and lymphoid organs. Recently its incidence has been gradually increasing because of developing diagnostic tools, increased use of steroids and immunosuppressive drugs, increased survival rate of patients with chronic diseases, and increased incidence of immunodeficiency syndrome. We report a case of pulmonary cryptococcosis in a patient with rheumatoid arthritis who was being treated with low dose glucocorticoid, methotrexate and cyclosporine for 14 months.
Sujets)
Humains , Polyarthrite rhumatoïde , Maladie chronique , Cryptococcose , Cryptococcus neoformans , Ciclosporine , Incidence , Foie , Poumon , Méthotrexate , Appareil respiratoire , Peau , Stéroïdes , Taux de survieRésumé
Subcutaneous granuloma annulare (SGA) is a rare, benign noninfectious histiocytic disease of unknown cause, characterized by necrobiosis of the connective tissue surrounded by infiltrates of histiocytes and lymphocytes. We report a case of SGA in a 49/12-year-old boy. The lesions were five nontender subcutaneous nodules in the parieto-occipital scalp, measuring 1.0 cm to 2.0 cm in diameter. Microscopical examination revealed variable stages of multiple necrobiotic areas, which showed central necrobiosis with palisading histiocytes, involving both the lower dermis and subcutaneous fatty tissue. Electron microscopic findings revealed many histiocytes in the necrobiotic areas with degenerating and necrotic collagen fibers as well as regenerating fibroblasts.