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1.
Indian J Ophthalmol ; 2000 Dec; 48(4): 307-9
Article Dans Anglais | IMSEAR | ID: sea-70505

Résumé

BACKGROUND: Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease. METHODS: TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17). RESULTS: Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01). CONCLUSION: The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.


Sujets)
Adolescent , Adulte , Marqueurs biologiques/sang , Plaquettes/métabolisme , Évolution de la maladie , Humains , Peroxydation lipidique/physiologie , Peroxydes lipidiques/sang , Rétinopathies/sang , Néovascularisation rétinienne/sang , Substances réactives à l'acide thiobarbiturique/métabolisme , Vascularite/sang
2.
Indian J Exp Biol ; 1992 May; 30(5): 399-401
Article Dans Anglais | IMSEAR | ID: sea-62877

Résumé

Effect of styrene (100 or 200 mg/kg body wt/day) for 60 days was observed on testicular enzymes of postnatally maturing rats. A significant decrease in epididymal spermatozoa count was observed only at 200 mg/kg body weight dose. Activities of testicular sorbitol dehydrogenase and acid phosphatase decreased while activities of lactate dehydrogenase, beta-glucuronidase, glucose-6-phosphate dehydrogenase, and gamma-glutamyl transpeptidase significantly increased only in animals exposed to styrene at a dose of 200 mg/kg body weight. The results suggest that exposure to high dose of styrene during developmental period alters the activities of enzymes associated with specific cell type of testis.


Sujets)
Animaux , Relation dose-effet des médicaments , Mâle , Rats , Rat Wistar/croissance et développement , Numération des spermatozoïdes/effets des médicaments et des substances chimiques , Styrène , Styrènes/administration et posologie , Testicule/effets des médicaments et des substances chimiques
3.
Indian J Exp Biol ; 1991 Nov; 29(11): 1044-6
Article Dans Anglais | IMSEAR | ID: sea-62632

Résumé

In utero exposure to di(2-ethylhexyl)phthalate (DEHP; 1000 mg/kg body weight) significantly decreased activities of testicular sorbitol dehydrogenase and acid phosphatase and increased gamma-glutamyl transpeptidase, lactate dehydrogenase and beta-glucuronidase activities at early ages. A decrease in the sperm count of the epididymal spermatozoa was also observed in the sexually matured animals of DEHP exposed group. The data suggest that in utero exposure to DEHP may affect the normal development of testes.


Sujets)
Animaux , Phtalate de bis[2-éthylhexyle]/toxicité , Femelle , Mâle , Grossesse , Effets différés de l'exposition prénatale à des facteurs de risque , Rats , Lignées consanguines de rats , Testicule/effets des médicaments et des substances chimiques
4.
Indian J Exp Biol ; 1991 Oct; 29(10): 943-5
Article Dans Anglais | IMSEAR | ID: sea-55853

Résumé

Mancozeb, a commonly used fungicide, has been shown to induce tumours in mouse skin and maneb, unit constituent of mancozeb, is reported to induce tumours in rats. The mechanism by which mancozeb induced tumorigenicity is not known. Since the levels of inositol phospholipids and phosphatidic acid have roles in the regulation of cell proliferation, the effects of mancozeb on the levels of these lipids were studied in rats. Daily oral administration of commercial grade mancozeb at a concentration of 50 mg/kg body wt for 30 days (5 days a week) caused no significant change in the levels of inositol phospholipids and phosphatidic acid (PA) in both cerebrum and liver, while at high concentration (250 mg/kg body wt) under the same treatment schedule mancozeb increased the levels of these lipids. In cerebrum, the levels of phosphatidylinositol (PI) and PA were increased by 36 and 43% respectively without affecting the levels of polyphosphoinositides, whereas in liver the levels of not only PI (50%) and PA (49%) but also those of polyphosphoinositides were increased. These results show that mancozeb influences the levels of PA and inositol phospholipids, involved in phospholipase C-pathway of signalling.


Sujets)
Animaux , Encéphale/anatomie et histologie , Relation dose-effet des médicaments , Femelle , Fongicides industriels/pharmacologie , Foie/anatomie et histologie , Manèbe/pharmacologie , Taille d'organe , Acides phosphatidiques/biosynthèse , Grossesse , Rats , Zinèbe/pharmacologie
5.
Indian J Exp Biol ; 1990 Jul; 28(7): 688-90
Article Dans Anglais | IMSEAR | ID: sea-58675

Résumé

Adult rats raised on 90% iron deficient diet for 6 weeks showed a decrease in the levels of brain phosphatidylinositol (60%), phosphatidylinositol 4-phosphate (25%) and phosphatidylinositol 4,5-bisphosphate (30%), the precursors for the second messengers, diacylglycerol and inositol phosphates. Rehabilitation to normal diet for 24 days was found to restore the levels to control values. The data suggests that iron deficiency could lead to alterations in the functions related to phosphoinositide-linked receptor system(s).


Sujets)
Animaux , Chimie du cerveau , Fer/déficit , Mâle , Lipides membranaires/analyse , Phosphatidyl inositols/analyse , Rats
6.
Indian J Exp Biol ; 1990 Jan; 28(1): 67-70
Article Dans Anglais | IMSEAR | ID: sea-58684

Résumé

Di-n-butyl phthalate (DBP) was administered to adult male rats by gavage at the doses of 250, 500 and 1000 mg/kg body weight/day for 15 days. A significant decrease in epididymal spermatozoa counts was observed at 500 and 1000 mg/kg doses of DBP. The activity of sorbitol dehydrogenase was found to be significantly decreased while that of lactate dehydrogenase, gamma-glutamyl transpeptidase, beta-glucuronidase, and glucose-6-phosphate dehydrogenase, significantly increased in the animals exposed to 500 and 1000 mg/kg of DBP. Decrease in the activity of acid phosphatase was also observed at all dose levels. Histopathological studies revealed marked degeneration of seminiferous tubules, further confirming testicular toxicity of DBP. The results suggest that testicular atrophy caused by DBP is associated with an alteration in the activities of enzymes related with specific events of spermatogenesis.


Sujets)
Animaux , Atrophie , Phtalate de dibutyle/toxicité , Mâle , Acides phtaliques/toxicité , Rats , Lignées consanguines de rats , Spermatogenèse/effets des médicaments et des substances chimiques , Testicule/effets des médicaments et des substances chimiques
7.
Indian J Exp Biol ; 1989 Oct; 27(10): 885-8
Article Dans Anglais | IMSEAR | ID: sea-57051

Résumé

Oral administration of DEHP, 1000 mg/kg body weight, to rats daily from 6 to 15 day of gestation resulted in retardation of fetal growth and increase in fetal liver weight which contained significant quantities of DEHP. The activities of mitochondrial succinate dehydrogenase, malate dehydrogenase, cytochrome c oxidase and adenosine triphosphatase were decreased in fetal liver. The data indicate that exposure of mothers to DEHP during pregnancy could adversely affect the fetal livers by interfering with bioenergetics of the cell.


Sujets)
Administration par voie orale , Animaux , Phtalate de bis[2-éthylhexyle]/toxicité , Femelle , Foetus/effets des médicaments et des substances chimiques , Foie/effets des médicaments et des substances chimiques , Échange foetomaternel , Acides phtaliques/toxicité , Grossesse , Rats
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