Résumé
Background: Postoperative pain after laparoscopic surgery limits the function and mobility of patients in postoperative period. Aim: The aim of present study is to study Flupirtine regarding its efficacy as preemptive analgesic in elective laparoscopic surgeries. Methods: In this randomized prospective study 100 patients were divided into two groups. Group-F received two capsules of Oral Flupirtine 100 mg each and group- P received two multivitamin capsules(placebo) with sip of water 2 hour before the expected time of induction of anaesthesia. Time for requirement of first dose of rescue analgesic post operatively, VAS score and dose of rescue analgesic used in first 24 hours post operatively were assessed. Results: Group F had lower visual analogue score(VAS) score in comparison to P group. Time for requirement of first dose of rescue analgesic in P group was less compared to F group. Consumption of rescue analgesic was less in F group in comparison to P group. Conclusion: Flupirtine as preemptive analgesic produced prolonged postoperative analgesia compared to placebo.
Résumé
Background: Though laparoscopic surgeries is less invasive and produces less post-operative pain,post-laparoscopy pain is still a concern. Intraperitoneal (IP) instillation of local anaesthetics has been shown to minimize the postoperative pain after laparoscopic surgeries. This study was conducted to compare the efficacy of intraperitoneal instillation of dexmedetomidine with bupivcaine and bupivacaine alone in reducing postoperative pain. Methods: 60 patients, enrolled for laparoscopic surgeries were divided randomly into two groups of 30 each. Group B: Bupivacaine (30ml,0.25%) with 2 ml normal saline was instilled prior to removal of trocars, and Group BD: Bupivacaine(30ml,0.25%) withdexmedetomidine(1mcg/kg,diluted to 2 ml) was instilled under prior to removal of trocars . In postoperative period, Visual Analogue Score (VAS) was recorded up to 24 hours. Postoperative analgesic requirements, and side effects were recorded. Results: The Visual Analogue Score (VAS) during the first postoperative 24 hours was significantly lower in group BD compared to group B. Time to first of analgesia required was delayed and total analgesic consumption was lower in group BD compared to group B which was statistically significant. Conclusion: Intraperitoneal instillation of dexmedetomidine with bupivcaine is an effective and safe method for reducing pain after laparoscopic surgeries.