Résumé
Background: Visual evoked potential [VEP] is one of the most important tests to differentiate migraine from any other headaches. This study was performed to evaluate the changes of VEP in migrainous patients
Materials and methods: In this case- control study, 50 patients with migraine referred to Basir Clinic in Tehran in 2014, were consecutively enrolled and the VEP results in them were determined and compared with 50 healthy subjects
Results: The mean [+/- standard deviation] voltage were 5.88+/-1.87 and 5.08+/-1.55 microvolt in the case and control groups, respectively [P=0.107]. The mean latency of case group was 94.32+/-7.31 milisecond, while it was 93.08+/-8.07 milisecod in the control group [P=0.572]
Conclusion: Totally, it is concluded that the recorded waves of VEP in migrainous patients are similar to healthy non migrainous people
Résumé
Quinine is used for treatment of many disorders, such as malaria and rheumatoid arthritis. Besides good therapeutic effects, it may have multiple adverse effects. In this study, the effects of quinine on latency and amplitude in visual evoked potential [VEP] were evaluated. In this experimental study, 50 male Syrian mice were used as control. Five groups of ten mice received doses of 2.5, 12.5, 25, 50, and 62.5 mg of quinine and one group of ten mice was given 70 mg acetone extract of Cinchona plant intraperitoneally for 14 days. The latency and amplitude of different groups in VEP were recorded. The latency was significantly increased, as parallel as dosage, in 14 days [P<0.05], while the amplitude was significantly decreased, as parallel as dosage, in 14 days [P<0.05]. Quinine resulted in significant increase of latency and decrease of amplitude and leaded to visual loss, possibly due to deposition of quinine on nerve fibers and cone-shaped and cylindrical cells leading to increase in latency phase of transmission from retina to fovea