Résumé
Postoperative nausea and vomiting is a major challenge with an incidence of 70% to 80%. This study evaluated the efficacy of Granisetron with or without Dexamethasone in reducing postoperative nausea and vomiting in patients undergoing elective plastic surgery procedures in Head and Neck region. A prospective, randomized, double blinded study of 90 patients undergoing plastic surgery procedures in Head and Neck region under general anesthesia with prophylactic Granisetron alone or combination of granisetron and dexamethasone or placebo was done. The main outcome measures were the occurrence of vomiting and severity of nausea up to 24 hours postoperatively. There was statistically significant difference in occurrence of postoperative nausea and vomiting when prophylaxis of granisetron alone or in combination with dexamethasone was given versus no prophylaxis. Although addition of dexamethasone further decreased the incidence of nausea and vomiting but the difference was not statistically significant It was concluded that in patients undergoing plastic surgery procedures in Head and Neck region, the addition of dexamethasone to granisetron decreased the incidence of postoperative nausea and vomiting up to 24 hours