Résumé
A prospective study of 200 Fine Needle Aspiration Cytology specimens from 194 patients with thyroid nodules at the University Hospital of the West Indies in Jamica showed a 95% accuracy when the results were compared with histopathology reports of the subsequent thyroidectomy surgical specimens in 86 patients. The false negative rate was 3% (for neoplasia), and there was a false positive rate of 10.5%. Fine Needle Aspiration Cytology thus proves to ben an accurate, specific and sensitive method of assenssment of thyroid nodules which ultimately reduces unnecessary surgical intervention
Sujets)
Adulte , Adulte d'âge moyen , Humains , Mâle , Femelle , Maladies de la thyroïde/anatomopathologie , Tumeurs de la thyroïde/anatomopathologie , Ponction-biopsie à l'aiguille , Études prospectives , Diagnostic différentiel , Faux positifs , Hyperplasie , JamaïqueRésumé
This report describes the main features of the 5 cases of polyarteritis nodosa seen at the University Hospital of the West Indies over a 10-year period. The disease manifestations are protean and only 2 of the 5 patients were diagnosed antemortem, indicating the need to increase physician awareness, especially since response to therapy has improved significantly in recent years
Sujets)
Adulte , Adulte d'âge moyen , Humains , Mâle , Polyartérite noueuseRésumé
In a retrospective study of hospital necropsies, we examined the kidneys of 21 patients with homozygous sickle-cell disease who died at the age of 40 or over. Renal failure had caused or contributed to death in ten cases. All kidneys showed changes of papillary damage to a variable extent. In three cases, there was mild cortical irregularity, and in thirteen, there was moderate to severe cortical irregularity, including scarring in some with obvious loss of functioning tissue. Light microscopic examination revealed hypertrophic glomeruli with increased cellularity, lobulation and capilary basement membrane splitting. Glomerulosclerosis was common, and patchy deposits of fibrin were present in glomerular capilaries in complex glomerulonephritis, we suggest that sclerosis consequent upon longstanding hyperfiltration may be more important. Glomerular filtration rate is abnormally high in children with sickle-cell disease but in later childhood renal insufficiency, proteinuria and eventually death from renal failure become common