Résumé
This study was carried out to find out the prevalence of Jervell and Lange Nielsen Syndrome [JLNS] in deaf school children for impaired hearing and to correlate this with consanguineous marriages. Setup: Schools for deaf and dumb children and Sheikh Zayed Medical College, Rahim Yar Khan. Cross sectional, case control study. 2006-2007. Electrocardiographs [ECG's] of 114 congenitally deaf school children [ages 4-20 years] and also of 23 healthy children with normal hearing function of same age group were recorded. The corrected QT [QTc] interval of all 137 ECGs was evaluated by Bazett's formula. Mean QTc of healthy children was taken as reference of normal QTc interval. The deaf children with normal QTc were labeled as control group. Patients with long QTc were further evaluated for JLNS by applying Schwartz's criteria. We also calculated the relationship of the positive cases to consanguineous marriages. We found that 28 deaf children out of 114 cases had QTc intervals longer than 0.44 seconds. This interval was significantly longer [P=0.008] than the QT interval in control group. As per Schwartz's criteria, 15 out of 28 LQTs cases scored high points [3.5 to 5.5]. The presence of consanguineous marriage was 100% in first pedigree of these 28 children. JLNS [an alarming arrhythmic disease associated with congenital deafness] is significantly present [24.6%] in Rahim Yar Khan's deaf school children. The presence of cousin marriage was 100% in first pedigree of these children
Résumé
Purpose: to quantify the degree of association between juvenile myopia and parental myopia and between juvenile myopia and near work
Methods: refractive error, parental refractive status, current level of near activities [assumed working distance-weighted hours per week spent studying, reading for pleasure, watching television, computer and playing outdoor sports] were assessed in 280 school children from high and low socio economic groups between ages of 8-15 years
Results: children with myopia were more likely to have parents with myopia than emmetropic children [p = 0.014]. Near work and sports activity had no significant influence on development of myopia in school going children of Rahim Yar Khan in any of the two socioeconomic groups
Conclusion: heredity is the most important factor associated with juvenile myopia
Résumé
Background: To quantify the degree of correlation between serum hormones [prolactin, FSH and testosterone] and sperm count in primary hypogonadism due to hyperprolactinemia in oligo/azoospermic infertile patients
Methods: Serum prolactin, FSH and testosterone levels of 100 male infertile oligospermic/ azoospermic patients were assayed by radioimmunoassay [RIA] and their data was analyzed for significant correlation with the same parameters of 20 control cases
Results: 25 out of 100 infertile patients had hyperprolactinemia out of which 13 had hypogonadism. Out of the 13 hyperprolactinemic hypogonadism cases, 9 had azoospermia. The values of serum prolactin and FSH were significantly raised [P<0.001]. The sperm count in the group was strongly correlated to serum FSH [r = 0.67 P<0.05]
Conclusion: Severe degree of hyperprolactinemia can cause infertility by inducing azoospermia directly. The levels of serum FSH rise in an attempt to reverse these changes
Résumé
In this study, serum magnesium and Na+ and K+ levels were studied in 88 patients of acute myocardial infarction [AMI] having their first episode and 37 healthy controlled subjects. All the AMI patients met the criteria of JSCC [2000]. They were carefully selected by strict inclusion and exclusion criteria. Patients of AMI were divided into three groups on the basis of their age. Methods:- All the patients were selected from the Emergency Department of Punjab Institute of Cardiology, Lahore. Prior to the starting of specific therapy streptokinase, a detailed history and general physical examination was performed and after meeting the AMI criteria for diagnosis consent proforma was filled, blood samples were collected in each case at the time of admission in the Emergency Ward. At the time of admission, serum magnesium levels were highly significantly lower [P < 0.001] as compared with the control group. Serum potassium levels were non significant [P > 0.05] in patients of AMI under the age of 60 years. While above the age of 60 years the serum potassium levels were significantly lower in the patients of AMI [P<0.05]. Conclusion: - It was concluded from this study that there was statistically significant hypomagnesemia [P<0.001] in the patients of AMI at the time of admission. It was also noted that there was significant hypokalemia in AMI patients [P<0.05] over the age of 60 years
Sujets)
Humains , Mâle , Magnésium/sang , Électrolytes/sang , HypokaliémieRésumé
Background: A cross sectional study held in infertility clinics of Multan under supervision of Federal Postgraduate Medical Institute, Sheikh Zayed Hospital, Lahore. The aim of the study was to look for any correlation between serum prolactin levels and semen parameters in oligospermic or azoospermic infertile males. Where hyperprolactinaemia was the only hormonal abnormality
Methods: We investigated 120 subjects [20 control and 100 infertile males]. The semen analysis was done according to WHO standard methods. The serum prolactin, FSH and testosterone were estimated by radioimmunoassay
Results: Percent motility [p<0.001] and motile density [p<0.01] of sperms had a strong negative correlation with the serum prolactin levels. The sperm count and percentage of normal morphology were not correlated [p>0.05] to serum prolactin levels in such males
Conclusion: Hyperprolactinaemia has a significant role in decreasing the sperm motility even without inducing hypo or hypergonadotropic hypogonadism