RÉSUMÉ
"Background: Vitiligo is not only a cosmetic problem, but also a social and psychological problemworldwide with the prevalence rate being highest in India. Treatment is unsatisfactory in WesternSystem of Medicine. Unani System of Medicine (USM) possesses various drugs to treat vitiligo inboth topical and oral dosage forms. Safoof-e-Bars (SB) is an important powdered dosage form usedwidely to treat vitiligo, internally as Zulal. Externally as Sufl (Sediment remained after decanting thesoaked drug) is used. Babchi, a component of SB, is reported to contain psoralen, an importanttherapeutically active compounds for treating vitiligo. But as Psoralen e the active marker compound is very slightly soluble in water, so only negligible amount of it comes in zulal and most ofthe amount remains in sufl. That might be the reason for local application of sufl as recommendedby Hakeems. But clinically it is observed that application of sufl is not followed by most of thepatients, due to side effects associated with its application on skin.Objective: The present study is designed to convert Safoof-e-Bars into a more convenient and appealingnewly evolved dosage form ‘emulgel’ of same composition as of SB, so that it can be used by the patientseasily without any side effects.Materials & methods: Various batches of emulgel were prepared as preliminary batches and final batchesusing hydro-alcoholic extract of SB and different excipients in different concentrations. Preliminarybatches were formed for selecting composition and concentration of extract and excipients for finalbatches. Total eight batches (F1eF8) were prepared as final batches. Among these eight batches, batch F7was selected as final batch, which was further evaluated on various parameters. Comparative quantitative analysis was done in Zulal, Hydro-alcoholic extract of SB and emulgel using HPLC.Results: Optimized emulgel showed good result in physicochemical parameters. Highest percentage ofpsoralen was found in SB extract while lowest percentage was found in zulal. No growth of yeast andmould, and viable aerobic were found in emulgel on microbiological analysis. Emulgel was found to bestable for 3 months.Conclusion: Newly developed emulgel may be recommended with zulal instead of traditionally used suflwith zulal. In future emulgel will provide a solution for topical delivery of hydrophobic drugs and moreconvenient dosage form to apply locally."
RÉSUMÉ
Background: Unani medicines are being used since antiquity. However, in spite of their effi cacy, they have been widely criticized due to lack of standardization and poor quality presentation. For this reason, application of good manufacturing practices and development of standard operating procedures (SOPs) in the manufacture of herbal medicines became an essential tool to assure their quality. Objectives: Therefore, the objective of the study was to develop the SOP of Habbe Shifa (HS) regarding the particle size (PS), binder, temperature of drying, and duration of drying. Materials and Methods: In this study, 24 batches of HS were prepared according to the instructions given in formulary to develop SOP. Three particle sizes (i.e., 80, 100, and 120 No. Mesh sieve), were taken for preparation of pills. Water and Samaghe Arabi (Gum Acacia mucilage [GAM]) were used as binder for preparing the lubdi (mass) in different batches. Different temperature and duration of drying were used to dry the pills in hot air oven to get satisfactory results. All the batches were assessed three times for hardness, friability, and disintegration time and mean regarded as standard parameter value. Results and Conclusion: The batch with 150 m PS (100 mesh sieve), 5% w/w GAM used as a binder, dried at 90°C for 120 min showed hardness 3.50 ± 0.00 kg/cm, friability 0.02 ± 0.003%, and disintegration time 25.00 ± 0.57 min, which showed most appropriate result among all batches and considered as fi nal batch. Its SOP may be used for future reference which can help in setting up regulatory limit to assure the quality of Unani medicines.
RÉSUMÉ
Dietary agents including spices, vegetables and fruits have drawn a great deal of attention from both the science peoples and the general public due to their various health promoting effects, these agents consist of a wide variety of biologically active compounds, many of them have been used as traditional medicines from thousands of years. Zingiber officinale commonly known as ginger is one of the most widely used species of the ginger family, commonly used as a condiment for various foods and beverages. It has a long history of medicinal use dating back 2500 years. Ginger is well known all over the world especially for its use in disorders of the gastrointestinal tract such as constipation, dyspepsia, diarrhoea, nausea and vomiting. Ginger is described by Dioscorides as hot, digestive, gently laxative and stomachic. This article aims at reviewing the Zingiber officinale on the basis of Traditional system of Medicine and to discuss its recent Phytochemical and Pharmacological studies.