RÉSUMÉ
Objective To study the expression of thyroid hormone receptor binding protein 4(TRIP4)and DNA damage inducing transcription factor 4(DDIT4)in glioma tissue and their relationship with clinical pathological characteristics and prognosis.Methods 94 glioma patients admitted to the First Hospital of Hebei Medical University from February 2018 to February 2019 were selected as the research subjects.The expression of TRIP4,DDIT4 proteins in tissues were detected by immunohistochemistry.The relationship between the expression of TRIP4,DDIT4 proteins in glioma tissues and clinical pathological characteristics were compared.The differences in survival prognosis of glioma patients with different levels of TRIP4,DDIT4 protein expression were analyzed by Kaplan-Meier survival curve.Univariate and multivariate COX regression analysis was conducted to analyze the factors affecting the survival prognosis of glioma patients.Results The positive rates of TRIP4(68.09%),DDIT4(65.96%)proteins in glioma tissues were higher than those in adjacent tissues(13.83%,10.64%),with statistically significant differences(χ2=57.212,60.866,all P<0.05).There was a significant positive correlation between TRIP4 and DDIT4 protein expression in glioma tissues(r=0.722,P<0.05).The positive rates of TRIP4(83.64%vs 46.15%,80.00%vs 51.28%)and DDIT4(80.00%vs 46.15%,76.36%vs 51.28%)proteins in glioma tissues with tumor diameter≥3cm,WHO grade Ⅲ were significantly higher than those in tissues with tumor diameter＜3cm,WHO grade Ⅰ～Ⅱ(χ2=6.393～14.754,P<0.05).The 3-year overall survival rates of the TRIP4 positive and negative expression groups were 37.50%(24/64)and 66.67%(20/30),respectively.The 3-year cumulative survival of the TRIP4 positive expression group was significantly lower than that in the TRIP4 negative expression group(Log-rank χ2=5.949,P=0.015).The 3-year overall survival rate of DDIT4 positive and negative expression group was 37.10%(23/62)and 70.00%(21/30),respectively.The 3-year cumulative survival of the DDIT4 positive expression group was significantly lower than that in the DDIT4 negative expression group(Log-rank χ2=7.642,P=0.006).Tumor diameter≥3cm(HR=1.614,P=0.000),WHO grade Ⅲ(HR=1.790,P=0.000),positive TRIP4(HR=1.665,P=0.000)and positive DDIT4(HR=1.476,P=0.000)were independent risk factors affecting the survival prognosis of glioma patients.Conclusion The expression of TRIP4 and DDIT4 protein in glioma tissue was increased.Both of them were related to tumor diameter and WHO grade,and are potential tumor markers for survival prognosis of glioma.
RÉSUMÉ
Objective To valuate the feasibility and safety of double stents-assisted coil embolization in the treatment of intracranial blood blister-like aneurysms.Methods The clinical data of 10 patients with BBAs who treated by double stents-assisted coil embolization were retrospectively reviewed.The clinical angiographic findings and follow-up restdts were analyzed and evaluated.Results The stent implantation were successfully performed in parent artery of 10 patients.There were 4 patients were performed with solo stents only because tumor was too small.5 patients were treated with double stents-assisted partial coil embolization.1 patient was treated with double stents-assisted totall coil embolization.The modified Rankin Scale score at the time of discharge in the alive patientswas 1 point in 5 patients,2 points in 2 patients,and 3 points in 1 patient,two patients died due to postoperative bleeding.The modified Rankin Scale score at 6-24 months after the treatment was 0 points in 5 patients,1 point in 2 patients,and 2 points in 1 patient,no rebteeding occurred.All patients received imaging follow-up to make sure the aneurysm imaging disappeared in 3 cases,3 cases of aneurysm development smaller,2 cases of imaging had no obvious change.Conclusion Double stents-assisted coil embolization is one of feasible methods for the treatment of BBAs.This method has high security,can reduce the fatality rate of BBAs.It is possible that new type low porosity stents may further reduce the risk of rebleeding and reoccurrence.