Sclerosing angiomatoid nodular transformation of spleen with calcifying fibrous pseudotumor: A rare case with unusual association

Sclerosing angiomatoid nodular transformation (SANT) of the spleen is a rare benign vascular lesion of the spleen that was first described in 2004. SANT is associated with other concurrent diseases, mostly malignancies. Calcifying fibrous pseudotumor (CFPT) is a tumor-like lesion usually arising from soft tissue or peritoneal sub-serosa. Both SANT and CFPT are considered to be variants of the inflammatory myofibroblastic tumor. We report the rare case of a 24-year-old female presenting with a left abdominal mass that was clinically diagnosed as an extraintestinal gastrointestinal stromal tumor (GIST). Histopathological examination revealed SANT of spleen and CFPT. We report this case due to its rarity of occurrence and unusual association of SANT with CFPT.

Carcinosarcoma of parotid gland - A rare case report.

Carcinosarcoma (true malignant mixed tumor) is an extremely rare tumor of the salivary gland. It is a biphasic tumor and is composed of both malignant epithelial and malignant mesenchymal component. Commonly, squamous cell carcinoma and adenocarcinoma forms the epithelial component and chondrosarcoma forms the mesenchymal component. We, hereby, report a parotid lesion in a 47 year old female that contained adenocarcinoma as epithelial component and chondrosarcoma as mesenchymal component. We report this unusual case of carcinosarcoma of parotid gland due to its rarity. It mimics benign lesions on ultrasonographic examination. On fine needle aspiration, the diagnosis of carcinosarcoma can be missed, as was in our case where it was reported as pleomorphic adenoma with atypical features. Histopathology only gives confirmatory diagnosis. In addition, a short review of literature along with possible pathogenesis of malignant mixed tumor of salivary gland is also presented.

Sarcomatoid Urothelial Carcinoma of Urinary Bladder – A Rare Case Report.

Sarcomatoid variant of urothelial carcinoma of urinary bladder is a rare tumor which exhibits epithelial and mesenchymal differentiation of tumor cells both morphologically and immunohistochemically. Cyclophosphamide treatment and radiation therapy are associated with this tumors. This tumor is considered to be the aggressive variant of transitional cell carcinomas of the bladder. Treatment for this aggressive tumor is radical surgical excision with chemoradiation. We report a case of 47-year-female presenting with dysuria and hematuria. On imaging, heterogeneously enhancing hyperdense lesion in bladder was noted which was diagnosed as sarcomatoid urothelial carcinoma on histopathological examination.