Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 1 de 1
Filtre
Ajouter des filtres








Gamme d'année
1.
Acta Pharmaceutica Sinica ; (12): 1447-1451, 2010.
Article Dans Chinois | WPRIM | ID: wpr-353341

Résumé

Inorganic/polymer hybrid star polylactic acid (POSS-PLA) was obtained through ring-opening polymerization of lactide by using polyhydroxyl cage silsesquioxane (POSS-OH) as the core and tin (II) octoate as the catalyst. The star polylactic acid (POSS-PLA) was used to modify sodium alginate hydrophobically and a drug carrier was obtained. The drug release behavior was investigated by using ibuprofen as the model drug. The results showed that the drug loading rate could be improved and the release rate was postponed with an increase of POSS-PLA content in the carries. The release mechanism gradually changed from the first-order to the zero-order pattern after the modification.


Sujets)
Alginates , Chimie , Matériaux biocompatibles , Préparations à action retardée , Vecteurs de médicaments , Chimie , Préparation de médicament , Méthodes , Acide glucuronique , Chimie , Acides hexuroniques , Chimie , Interactions hydrophobes et hydrophiles , Ibuprofène , Acide lactique , Chimie , Microscopie électronique à balayage , Microsphères , Nanostructures , Polyesters , Polymères , Chimie
SÉLECTION CITATIONS
Détails de la recherche