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Objective To explore the effect of curved supine position to prevent pressure ulcer and comfort experience in postoperative fracture patients. Methods A total of one hundred and seventy-eight leg fracture patients who underwent operating in hospital were randomly divided into study group and control group (89 patients in each group). Conventional prevention and nursing method was given in the control group, based on the control group, curved supine position nursing method was carried out in the study group. The incidence of pressure ulcer, main compressed parts, pressure ulcers risk score and comfort degree in two groups were compared during hospitalization. Results The incidence of pressure ulcer in the study group (1.1％,1/89) was significantly lower than in the control group (7.9％,7/89), the difference was statistically significant between two groups (χ2=4.712, P=0.030). The scores of Kolcaba General Comfort Questionnaire (GCQ) in two groups showed a time-dependent manner, the physical, psycho-spiritual, environmental scores in the study were higher than in the control group at 13:00, 17:00 and 20:00. Meanwhile, the scores of socio-cultural were higher than in the control group at 17:00 and 20:00, the difference was statistically significant between two groups (P<0.05). Conclusion Curved supine position canreduce the incidence of pressure ulcer as well as promote comfort experience in postoperative fracture patients.
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Objective To evaluate the effects of dexmedetomidine on responses to tourniquet in patients undergoing lower extremity surgery with peripheral nerve block.Methods Eighty American Society of Anesthesiologists physical status Ⅰ or Ⅱ patients of both sexes,aged 22-63 yr,weighing 47-81 kg,scheduled for elective foot surgery under ultrasound-guided popliteal sciatic nerve block combined with saphenous nerve block,were divided into 2 groups (n =40 each) using a random number table method:control group (group C) and dexmedetomidine group (group D).Dexmedetomidine was intravenously infused for 10 min in a dose of 1 μg/kg in group D,and the equal volume of normal saline was given instead in group C.Blood samples were taken from the internal jugular vein before using the tourniquet (T0) and at 30 and 60 min after releasing the tourniquet (T1-2) for determination of the levels of c-reactive protein (CRP),tumor necrosis factor-alpha (TNF-α),methane dicarboxylic aldehyde (MDA) and superoxide dismutase (SOD) in plasma.The time to responses to tourniquet,tourniquet tolerance time and tourniquet tolerance period were recorded.The occurrence of hypotension,bradycardia and nausea and vomiting was also recorded.Results Compared with the baseline at T0,the concentrations of plasma CRP,TNF-α and MDA were significantly increased and the activity of plasma SOD was decreased at T1,2 in the two groups (P＜0.05).Compared with group C,the concentrations of plasma CRP,TNF-α and MDA were significantly decreased and the activity of plasma SOD was increased at T1,2,the time to responses to tourniquet,tourniquet tolerance time and tourniquet tolerance period were prolonged,and the incidence of bradycardia was increased in group D (P＜0.05).Conclusion Dexmedetomidine can reduce responses to tourniquet in patients undergoing lower extremity surgery with peripheral nerve block.
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Objective To evaluate the effects of doxofyline on intraoperative pulmonary function in patients receiving double lumen endotracheal intubation for one-lung ventilation. Methods Fifty patients who underwent elective pulmonary lo-bectomy under general anesthesia using double lumen endotracheal intubation were randomly divided into two groups ( n=25 each):control group (group C) and doxofyline group (group D).Doxofyline (4 mg?kg-1) was injected intravenously after double lumen endotracheal intubation in group D,while equal volume of 0.9% sodium chloride was intravenously given in group C.Total intravenous anesthesia with target controlled infusion was performed during the operation.Two milliliter blood samples were taken from the radial artery for blood gas analysis immediately before administration ( t0 ) ,at 30 min ( t1 ) ,60 min ( t2 ) after one-lung ventilation and at the moment of two-lung ventilation after chest closing ( t3 ) . The PaCO2 , PaO2 , peak airway pressure (Ppeak),airway plateau pressure (Pplat),airway resistance (Raw) and lung compliance (Compl) were recorded at t0-3. Results The Ppeak,Pplat and Raw were significantly decreased and the Compl and PaO2 significantly increased at t1-t3 in group D when com-pared with those in group C (P<0.05).The Ppeak,Pplat and Raw were significantly increased and Compl and PaO2 significantly de-creased at t3 as compared with those at t0 in group C ( P<0.05) . Conclusion Doxofyline can improve intraoperative pulmonary function in patients who undergo double lumen endotracheal intubation for one-lung ventilation.
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Objective To investigate the distribution of human papillomavirus (HPV) genotypes in male patients with anogenital warts in Lishui area,Zhejiang province.Methods Tissue specimens were obtained from the lesions of 150 male patients with anogenital warts.PCR-reverse dot blot hybridization was performed to detect the presence of 3 low-risk HPV types (HPV 6,11,and 43) and 16 moderate-or high-risk HPV types (HPV 16,18,31,33,35,39,45,51,52,53,56,58,59,66,68 and CP8304) in these specimens.Chi-square test was used for statistical analysis.Results HPV was detected in 91 (60.67％) of the 150 male patients.Of the 91 positive patients,74 (81.32％) were infected by single or multiple low-risk HPV types,whereas 17 (18.68％) by single or multiple high-risk HPV types.Thirty-one (34.07％) patients harbored 2-5 HPV genotypes,including 20 (64.52％)patients infected with both low-risk and high-risk HPV types,and 6 (19.35％) patients infected with two low-risk HPV types.The coexistence of moderate-or high-risk HPV types with HPV 6 was observed in 13 (41.94％)patients,and that with HPV 11 in 6 (19.35％) patients.The most prevalent genotype was HPV 6 (28.68％,39/136),followed by HPV 11 (26.47％,36/136),16 (8.09％,11/136),52 (5.15％,7/136),53 (5.15％,7/136),51 (4.41％,6/136),58 (4.41％,6/136) and 43 (4.41％,6/136).Conclusions Low-risk HPV genotypes predominate in male patients with anogenital warts,and there are large differences in the distribution of multiple infections and HPV genotypes.
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Objective To evaluate the feasibility of using lumbar plexus block for unilateral extremity artificial vascular graft between femoral artery and deep femoral artery in elderly patients.Methods Forty ASA physical status Ⅱ or Ⅲ patients,aged 67-81 yr,weighing 47-65 kg,scheduled for extremity artificial vascular graft between femoral artery and deep femoral artery,were randomly divided into 2 groups (n =20 each) using a random number table:spinal anesthesia group (group S) and lumbar plexus block group (group L).In group S,0.5 ％ hyperbaric ropivacaine 3 ml was injected into the subarachnoid space.In group L,lumbar plexus block was performed with 30 ml of 0.5 ％ ropivacaine under the guidance of a nerve stimulator.The onset time and duration of sensory block,anesthetic efficacy,and requirement for ephedrine and volume of fluid infused during operation,and development of lumbar plexus block-related adverse events were recorded.Results Compared with group S,the onset time and duration of sensory block were significantly prolonged,the requirement for ephedrine and volume of fluid infused during operation were decreased,and no significant change was found in anesthetic efficacy in group L.No lumbar plexus block-related adverse events developed in group L.Conclusion Lumbar plexus block can be used for unilateral extremity artificial vascular graft between femoral artery and deep femoral artery in elderly patients.
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Objective To explore the effect of humidification of oxygen delivered by nasal cannula on the respiratory symptoms. Method A total of 540 patients receiving low-to-mid flow oxygen therapy (<4L/min) by nasal cannula for more than 12 hours were assigned to receive humidified (n=235) or dry (n=305)oxygen. While 226 patients receiving a low-to-mid flow oxygen therapy for more than 24 hours received humidified or dry oxygen respectively. The patients' respiratory symptoms were observed and recorded. Results Dryness over naso-pharyngeal region was the only symptom reported by patients in this study. There was no significant difference on the rate of dryness over naso-pharyngeal region between patients receiving humidified oxygen and patients receiving dry oxygen (P>0.05) either in the same patients when receiving dry and humidified oxygen (P>0.05). Conclusion Routine humidification is not necessary in low-to-mid flow oxygen therapy by nasal cannula.
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Objective To discuss influence of the humidification or non-humidification on oxygen humidity during low-mid volume oxygen inhalation through nasal cannula.Methods A total of 160 patients with low-mid volume oxygen inhalation through nasal cannula for≥12 hours were randomly assigned to the humidified group and the un-humidified group with 80 patients in each.Recording the chases of oxygen humidity from the humidifying bottles.at the same time the indoor air humidity was also observed.Influence of the humidification or non-humidification on oxygen humidity during low-mid volume oxygen inhalation through nasal cannula was observed.Results There was not significant difference in oxygen humidity between the two groups.Conclusions Routine humidifying is not necessary in low-mid volume oxygen inhalation through nasal cannula.