Résumé
【Objective】 To investigate the effects and potential mechanisms of neurodegenerative lesions in male mice caused by ozone exposure. 【Methods】 We divided 23 C57BL/6N male mice aged 8 to 9 months into control group （clean air group， 11） and ozone group （1 mg/m 3， 4h/d， 12）. After 8 weeks of continuous ozone exposure， the Morris water maze experiment was used to detect the mice’s learning and memory ability， HE dyeing to observe pathological changes in hippocampal tissue cells， and immunoprinting tests to detect the expression levels of Tau， p-Tau and α-synuclein proteins in the cerebral cortex tissue. 【Results】 After 8 weeks of ozone exposure， the mice’s spatial learning and memory ability were impaired to a certain extent， the incubation period decreased with time， and the two lines were separated， but the difference was not statistically significant. Ozone exposure caused changes in the morphology of the mice’s hippocampal tissue cells， disorders in the arrangement of hippocampal neuron， and nuclear wrinkles， and significantly increased levels of p-Tau and α-synuclein protein expressions in cerebral cortex tissues （P<0.01）， but there was no statistical significance in the total Tau expression level. 【Conclusion】 Ozone exposure leads to the loss of learning and memory in mice， changes in hippocampal neurocellular pathology， and increased expression levels of neurodegenerative variable-related proteins.
Résumé
Objective To discuss the feasibility and the security of implementing the abodomen-type horizon- tal margin improvement in-fascia womb excision method to the womb benign pathological change.Methods Among the womb bening pathological change patients who were treated in our hospital from October 2000 to October 2004. 80 examples were implemented the abdomen-type horizontal margin improvement in-fasica womb excision method as the research group and 90 examples were implemented the traditional vertical margin womb excision method as the comparison group.The patients' age,sickness type,the womb size and the pelvic cavity adhesion of the tub groups had no significant difference.The surgery time,the bleeding quantity in the course of the operation,the margin ache situation,the exhaust time and getting sick rate after the surgery,the exhaust time and getting sick rate after the surgery,the hospitalization time and sex life situation after the surgery,and so on were analyzed.Results The re- search group's bleeding quantity in the course of the operation,the margin ache,the exhaust time and getting sick rate after the operation were obviously lower than those of the comparison group(P＜0.05),moneover,it was not found out that the vagina remnant end was exceptional,and the vagina wall was nelaxing or escaping or hanging,the degnce of satisfaction to the sex life obviously surpasses that of the comparison group(P＜0.05).Conclusion The abdomen-type horizontal margin inprovement in-fascia womb excision method is safe and feasible to the womb benign pathological change.