The Search for a Receptor for Cell Infection by Bovine Leukemia Virus: Data Mining and Signaling Pathways Analysis

The bovine leukaemia virus (BLV) is widely spread all over the world. Currently, treatment of leukaemia-infected animals is not carried out. Not all virus carriers become ill with leukaemia. The existing genetic resistance to the disease is due to the presence of alleles of resistance of the main histocompatibility complex. However, another mechanism of resistance is possible, which is associated with the penetration of the virus into the cell. The work aimed to analyse the currently available data on possible receptors of the virus. Four potential molecules were found. The results suggest that the potential BLV receptor is a CD209 protein.