Protein interaction network analysis of Panax notoginseng saponins / 中国中药杂志

Panax notoginseng (PN) is one of the commonly used clinical medicines for cardiovascular diseases and possesses a variety of pharmacological effects. P. notoginseng saponins (PNS) are the most important bioactive components in PN. The purpose of this study was to explain the mechanism of PNS on molecular network level. 18 targets of the main medicinal ingredients of PNS were gained by virtual screening based on pharmacophores and data mining. A protein interaction network of PNS was constructed with 189 nodes and 721 interactions. By a graph theoretic clustering algorithm Molecular Complex Detection (MCODE), 14 modules were detected. Gene ontology (GO) enrichment analysis of the modules demonstrated that the roles of PNS played in cardiovascular disease related to multiple biological processes, which could represent the characteristics of traditional Chinese medicine (TCM) as a whole to regulate the disease. The results showed that the blood circulation and hemostasis efficacy of PN related with the biological processes such as positive regulation of cAMP metabolic and biosynthetic process, platelet activation and regulation of blood vessel size, regulation of T cell proliferation and differentiation and so on. Therefore, the module-based network analysis will be an effective method for better understanding TCM.

Process of submarine medical rescue based on MedModel: A simulation application research / 第二军医大学学报

Objective To optimize the constitutionsof the rescue process and medical support teams for submarine rescue, so as to provide new method for evaluating the medical service performance. Methods Using the MedModel software, we established the simulation model of rescue process according to the constitution and work flow for submarine rescue and five ways of getting out of thewater. The mean waiting time of 5 ways was calculated. Results According to the ways of getting out of water, the mean waiting time of each way were calculated and the allocation of medical resources were optimized, making the total waiting time meeting the need of medical rescue team. Conclusion This paper optimizes the rescue process and constitution of the rescue team, saving the medical resources, reducing the total waiting time of the wounded, and providing a new method for evaluating medical serves.