Résumé
Background: Perforated peptic ulcer is an emergencycondition worldwide. The series comprises study of 100 casesof peptic ulcer perforation by conservative management.Objective: The objective of this study is to find out thetreatment outcome of selective cases of perforated peptic ulcerdisease with conservative measures.Method: This prospective study was conducted at SurgeryDepartment of M. Abdur Rahim Medical College Hospital,Dinajpur, Bangladesh for a period of July 2008 to July 2009.The cases were selected by special inclusion and exclusioncriteria.Results: All patients were presented with acute upperabdominal pain, most were in their fourth decade and came tothe hospital around twenty four hours of their onset of pain.Diagnosis was made on clinical grounds and confirmed byradiological and imaging examinations. Resuscitativemeasures were taken in all cases in the form of IV fluid,nasogastric suction, antibiotics and analgesics. The study wasdesigned to treat all the patients conservatively andaccordingly all were given conservative regimen up to 24hours. There after they were assessed clinically. Greatdeterioration was found in 12 patients and 18 patients showedno improvement who were operated immediately. Conservativemeasures were continued for 70 patients who respondedsmoothly with few minor complications. The mortality was6.33% in the cases treated operatively after failing conservativemanagement.Conclusion: In this series there is a strong associationbetween age of the patient, duration of acute illness andoutcome. It is suggested that treatment of selected cases ofperforated peptic ulcer disease with conservative measures issafe and effective.