1.
Japanese Journal of Complementary and Alternative Medicine
;
: 45-49, 2013.
Article
Dans Japonais
| WPRIM
| ID: wpr-376368
Résumé
We purified a novel angiotensin-I converting enzyme (ACE) inhibitor from fish sauce <i>Ishiru</i> prepared from squid, and identified it as the tripeptide Leu-Ala-Arg (LAR). IC<sub>50</sub> of this ACE inhibitor was 2.5 μM, demonstrating high potency among peptides previously purified from fish sauces. Moreover, LAR acted as an antihypertensive peptide, reducing systolic blood pressure in spontaneously hypertensive rats.<br>