Latent structure model evaluation of syndrome elements and features in 826 hypertriglyceridemia patients / 中国中西医结合杂志

<p><b>OBJECTIVE</b>To evaluate main Chinese medical syndrome elements and features of hypertriglyceridemia patients.</p><p><b>METHODS</b>Using latent structure model (LSM) method, the latent structure diagram of 826 hypertriglyceridemia patients were established. Hypertriglyceridemia syndrome elements and features were interpreted by using latent probability, conditional probability, mutual information, and cumulative information coverage to quantify symptoms/syndromes data,as well as using manual interpretation methods.</p><p><b>RESULTS</b>The accumulative information coverage rate reaching 95% was taken as the judgment standard for major syndrome elements. In the 826 hypertriglyceridemia patients, moderate and severe symptoms/syndromes (with the latent probability being 35% and 60% respectively) were dominant. The syndrome elements mainly included qi deficiency, qi stagnation,fire heat, stasis blood, yin deficiency, and yang deficiency. The main targets were dominated in Xin, Gan, and Shen.</p><p><b>CONCLUSION</b>LSM based syndrome element evaluation method could quantify the association degree of each variable (syndrome element; Chinese medical symptoms) and the occurrence probability.</p>

A new monacolin analogue from Xuezhikang capsule / 药学学报

Xuezhikang capsule (ethanol extract of red yeast rice) which produced by Beijing WBL Peking University Biotech Co., Ltd., is a traditional Chinese medication with 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibiting activity. Clinical trials indicated that Xuezhikang with lipid-lowering action could reduce the risk of cardiac events and total mortality of Chinese coronary heart disease patients. To exactly explain the clinical features of Xuezhikang, we undertook a complete study of the chemical constituents of Xuezhikang. This study resulted in the isolation of a new monacolin analogue, named alpha, beta-dehydromonacolin L (1), along with two known compounds: monacolin L (2) and 3-(2, 6-dimethyl-1, 2, 4a, 5, 6, 7, 8, 8a-octahydronaphthalen-1-yl)propanoic acid (3). The chemical structures were determined by extensive 1D and 2D NMR and MS spectroscopic analysis.

A new isoflavone from Huoxue Yiqi Tang / 中国中药杂志

<p><b>OBJECTIVE</b>To study the chemical constituents in the active parts of Huoxue Yiqi Tang.</p><p><b>METHOD</b>The silica gel, Sephadex LH-20 were used to isolate the compounds, El, FAB-MS and 1D, 2D-NMR were used to identify the obtained compounds.</p><p><b>RESULT</b>14 compounds were obtained from the prescription.</p><p><b>CONCLUSION</b>They were all first time obtained from the prescription. Among them, 7, 3'-dihydroxyl-5'-methoxyisoflavone is new.</p>

Effects of berberine on EEG and EEG power spectrum recorded in conscious rabbits / 中国临床药理学与治疗学

Aim In order to study the mechanisms of underlying improving learning and memory in rodent, the effects of berberine (Ber) on EEG and EEG power spectrum were recorded in conscious rabbits.Methods EEG and EEG power spectrum were recorded in conscious rabbits with chronical implanted electrodes.Results Ber at doses of 1～4 mg?kg-1 iv showed to decrease dose_dependently the spectrum power of delta dominant frequency in cortical area and transfer the dominant frequency from delta to theta rhythm in hippocampus.Under the same conditions, the effects of physostigmine 0.1 mg?kg -1 iv on EEG were similar to Ber.Ber 2 mg?kg-1 iv reversed significantly these effects of Ber 0.05 mg/rabbit iv on EEG and power spectrum, but scopolamine butylbromide 0.4 mg?kg-1 iv, which can not pass the blood_brain barrier, did not.Conclusion The effects of Ber are closely related to the action on the central cholinergic system.