Résumé
Objective To investigate the pregnancy outcomes of in vitro fertilization (IVF) and embryo transfer (ET) in infertile women with polycystic ovarian syndrome (PCOS).Methods From August 2005 to June 2011,200 IVF-ET cycles performed in women with polycystic ovarian syndrome in Shengjing Hospital and Shenyang 204 Hospital were enrolled in this retrospective study,matched with 400 IVF-ET cycles in infertile women with fallopian tube factors as control group.The incidence of abortion,gestational diabetes mellitus (GDM),hypertensive disorders in pregnancy,preterm birth,small for gestational age infant(SGA),large for gestational age infant (LGA),neonatal asphyxia,neonatal death and deformity was compared between two groups.Results The incidence of spontaneous abortion was 26.0％ (52/200) in PCOS group,which was significantly higher than 10.2％ (41/400) in control group (P ＜ 0.05).The incidence of GDM,hypertensive disorders in pregnancy,preterm birth,cesarean section in PCOS group was 23.6％ (35/148),16.2％ (24/148),17.6％ (26/148),83.1％ (123/148),which were significantly higher than 4.2％ (15/359),6.1％ (22/359),7.8％ (28/359),73.8％ (265/359) in control group (P ＜0.05).The incidence of SGA,LGA,neonatal asphyxia,neonatal death and deformity did not show remarkable difference between two groups,which were 2.7％ (4/148),4.7％ (7/148),5.4％ (8/148),0 in PCOS group and 1.4％ (5/359),2.2％ (8/359),2.8％ (10/359),0 in control group (P ＞0.05).Conclusion IVF-ET is an effective treatment for infertile women with PCOS,however,the incidence of spontaneous aborcion,GDM,hypertensive disorders in pregnancy,preterm birth,cesarean section in PCOS patients was increased.
Résumé
Purpose:To study the expression of Survivin,P21 WAF1/CIP1 and CyclinD1 proteins in cervical carcinoma and to investigate their relation to recurrence of early stage cervical cancer of the uterus.Methods:Using streptavidin-biotin peroxidase (sp) method,we examined the protein expression of Survivin, P21 WAF1/CIP1 and Cyclin D1 in 55 cervical carcinomas (45 cervical squamous carcinomas and 10 cervical adenocarcinomas ) and 10 normal cervical tissues.Results:① The positive rates of Survivin,Cyclin D1,P21 WAF1/CIP1 were 0,10.0%,20.0% in normal cervical tissue,and 68.9%,51.1%,57,8% in cervical squamous carcinomas,and 60.0%,90.0%,80.0% in cerrical adenocarcinomas respectively. There were significant differences in the positive results of Survivin,CyclinD1,P21 WAF1/CIP1 between normal cervical tissue and cervical cancer ( P 0.05).③The coexpression of Survivin with P21 WAF1/CIP1 or CyclinD1 were both associated with higher tumor grade( P