Résumé
<p><b>OBJECTIVE</b>To develop a HPLC method for the determination of synephrine and arecoline contents in Xiao'er Xiaoji Zhike oral liquid.</p><p><b>METHOD</b>The analysis was performed on a Symmetry C18 column (4.6 mm x 250 mm, 5 microm) eluted with acetonitrile-methanol-0.1% acetic acid solution (containing potassium dihydrogen phosphate 0.6 g and SDS 1.0 g per 1 000 mL) (15: 30: 55) as mobile phase. The detection wavelength was set at 215 nm.</p><p><b>RESULT</b>The synephrine and arecoline concentrations had good linear relationship between 0.281 5-2.815 and 0.040 16-0.401 6 microg (r > 0.999 7), and the average recoveries of the two compounds were 97.1% (RSD 1.4%) and 100% (RSD 1.3%), respectively.</p><p><b>CONCLUSION</b>The method is simple, accurate and sensitive.</p>