Strain do Átrio Esquerdo pela Técnica de Speckle-Tracking: Contribuição para a Avaliação da Função Diastólica em Pacientes Pediátricos com Doença Renal Crônica / Speckle-Tracking: Incremental Role in Diastolic Assessment of Pediatric Patients with Chronic Kidney Disease

Resumo Fundamento: As complicações cardiovasculares são a principal causa de morte em pacientes pediátricos com doença renal crônica (DRC). A avaliação ecocardiográfica da função diastólica na DRC tem se limitado à avaliação espectral por Doppler espectral e por Doppler tecidual, técnicas sabidamente menos confiáveis na pediatria. O strain do átrio esquerdo (AE) pela técnica do speckle tracking bidimensional (2DST) foi recentemente confirmada como uma medida robusta da função diastólica. Objetivos: Investigar o papel do strain do AE na avaliação da função diastólica de crianças em diferentes estágios da DRC. Métodos: De fevereiro de 2019 a julho de 2022, 55 pacientes com DRC sem sintomas cardiovasculares e 55 controles foram avaliados por ecocardiografia convencional e por ecocardiografia com 2DST. O nível de significância adotado foi de 5% (p < 0,05). Resultados: Pacientes e controles tinham idade similares [9,78 (0,89 - 17,54) vs. 10,72 (1,03 -18,44) anos; p = 0,41] e sexo (36M:19F vs. 34M:21F; p = 0,84) similares. Havia 25 pacientes não dialíticos e 30 pacientes dialíticos. A fração de ejeção do ventrículo esquerdo foi ≥ 55% em todos. Em comparação aos controles, os pacientes com DRC apresentaram strain de reservatório mais baixo (48,22±10,62% vs. 58,52±10,70%) e índice de rigidez do AE mais alto [0,14 (0,08-0,48)%-1 vs. 0,11 (0,06-0,23) %-1]; p<0,0001. A hipertrofia ventricular esquerda associou-se com um strain de reservatório mais baixo (42,05±8,74% vs. 52,99±9,52%), e valores mais altos de índice de rigidez [0,23 (0,11 - 0,48)%-1 vs. 0,13 (0,08-0,23) %-1 e de índice de enchimento do AE (2,39±0,63 cm/s x %-1 vs. 1,74±0,47 cm/s x %-1; p<0,0001). Hipertensão não controlada associou-se com strain de reservatório do AE mais baixo (41,9±10,6% vs. 50,6±9,7; p=0,005). Conclusão: O strain do AE mostrou-se uma ferramenta útil na avaliação de pacientes pediátricos com DRC e associado com fatores de risco cardiovasculares conhecidos.

Abstract Background: Cardiovascular complications are the leading cause of mortality in pediatric patients with chronic kidney disease (CKD). Echocardiographic assessment of diastolic function in CKD has been limited to spectral and tissue Doppler imaging, known to be less reliable techniques in pediatrics. Two-dimensional Speckle tracking echocardiography (2DST) derived left atrial (LA) strain has recently been confirmed as a robust measure of diastolic function. Objectives: To investigate LA strain role in diastolic assessment of children at different stages of CKD. Methods: From February 2019 to July 2022, 55 CKD patients without cardiovascular symptoms and 55 controls were evaluated by standard and 2DST echocardiograms. The level of significance was set at 5% (p<0.05). Results: Patients and controls had similar age [9.78 (0.89 - 17.54) vs. 10.72 (1.03 -18,44) years; p = 0.41] and gender (36M:19F vs. 34M:21F; p=0.84). There were 25 non-dialysis patients and 30 dialysis patients. Left ventricular ejection fraction was ≥ 55% in all of them. Comparing CKD and controls, LA reservoir strain was lower (48.22±10.62% vs. 58.52±10.70%) and LA stiffness index was higher [0.14 (0.08-0.48)%-1 vs. 0.11 (0.06-0.23) %-1]; p<0.0001. LV hypertrophy was associated with lower LA reservoir strain (42.05±8.74% vs. 52.99±9.52%), higher LA stiffness [0.23(0.11 - 0.48)%-1 vs. 0.13 (0.08-0.23) %-1 and filling indexes (2.39±0.63 cm/s x %-1 vs. 1.74±0.47 cm/s x %-1; p<0.0001. Uncontrolled hypertension was associated with lower LA reservoir strain (41.9±10.6% vs. 50.6±9.7; p=0.005). Conclusions: LA strain proved to be a feasible tool in the assessment of pediatric CKD patients and was associated with known cardiovascular risk factors.

Food environment of bus terminals in the Rio de Janeiro metropolitan region / Ambiente alimentar de terminais rodoviários da região metropolitana do Rio de Janeiro

ABSTRACT PURPOSE To describe and analyze the healthiness of formal and informal food establishments in bus terminals of the metropolitan region of the state of Rio de Janeiro. METHOD An audit was conducted in 156 formal and 127 informal food establishments located in 14 bus terminals of the five most populous cities of the metropolitan region of Rio de Janeiro. Proportions of types of establishments and means (95%CI) of food availability indicators in formal and informal settings were calculated. For the formal setting, prices, proportions of accepted payment methods, days and hours of operation, and food categories with displayed advertising were described. RESULTS The healthiness of food establishments in bus terminals was low (less than 36%). On average, ultra-processed food subgroups were 250% more available for purchase than fresh or minimally processed food. Purchasing food at these places was convenient because several forms of payment were available, and the opening hours of the establishments followed the peaks of movement. In addition, 73.3% of the advertising referred to ultra-processed drinks, and the cost-benefit of buying ultra-processed food was better than fresh or minimally processed food. CONCLUSION The food environment of bus terminals in the metropolitan region of Rio de Janeiro promotes unhealthy eating. Regulatory public policies should focus on initiatives to limit the wide availability and advertising of ultra-processed food in spaces of great circulation of people.

RESUMO OBJETIVO Descrever e analisar a saudabilidade dos estabelecimentos com venda formal e informal de alimentos em terminais rodoviários da região metropolitana do Rio de Janeiro. MÉTODOS Realizou-se auditoria em 156 estabelecimentos formais e 127 pontos informais de venda de alimentos localizados em 14 terminais rodoviários das cinco cidades mais populosas da região metropolitana do Rio de Janeiro. Foram calculadas proporções de tipos de estabelecimentos e médias (IC95%) de indicadores de disponibilidade de alimentos nos ambientes formal e informal. Para o ambiente formal, foram descritos preços, proporções das formas de pagamento aceitas, dias e horários de funcionamento e categorias de alimentos com propaganda exposta. RESULTADOS A saudabilidade dos pontos de venda de alimentos nos terminais rodoviários era baixa (inferior a 36%). Em média, estavam disponíveis para compra 250% mais subgrupos de alimentos ultraprocessados do que in natura ou minimamente processados. Adquirir comida nesses locais era conveniente porque diversas formas de pagamento estavam disponíveis e os horários de funcionamento dos estabelecimentos acompanhavam os picos de movimentação. Além disso, 73,3% das propagandas se referiam a bebidas ultraprocessadas e o custo-benefício da compra de alimentos ultraprocessados era melhor que o de alimentos in natura ou minimamente processados. CONCLUSÃO O ambiente alimentar dos terminais rodoviários da região metropolitana do Rio de Janeiro promove uma alimentação não saudável. Políticas públicas de regulação devem se concentrar em iniciativas que limitem a ampla disponibilidade e publicidade de alimentos ultraprocessados nesses espaços de grande circulação de pessoas.

The action of microbial collagenases in dentinal matrix degradation in root caries and potential strategies for its management: a comprehensive state-of-the-art review

Abstract Conventional views associate microbial biofilm with demineralization in root caries (RC) onset, while research on their collagenases role in the breakdown of collagen matrix has been sporadically developed, primarily in vitro. Recent discoveries, however, reveal proteolytic bacteria enrichment, specially Porphyromonas and other periodontitis-associated bacteria in subgingivally extended lesions, suggesting a potential role in RC by the catabolism of dentin organic matrix. Moreover, genes encoding proteases and bacterial collagenases, including the U32 family collagenases, were found to be overexpressed in both coronal and root dentinal caries. Despite these advancements, to prove microbial collagenolytic proteases' definitive role in RC remains a significant challenge. A more thorough investigation is warranted to explore the potential of anti-collagenolytic agents in modulating biofilm metabolic processes or inhibiting/reducing the size of RC lesions. Prospective treatments targeting collagenases and promoting biomodification through collagen fibril cross-linking show promise for RC prevention and management. However, these studies are currently in the in vitro phase, necessitating additional research to translate findings into clinical applications. This is a comprehensive state-of-the-art review aimed to explore contributing factors to the formation of RC lesions, particularly focusing on collagen degradation in root tissues by microbial collagenases.

Prevalence and factors associated with anxiety, depression and burnout in gynecology and obstetrics residents during the COVID-19 pandemic

Abstract Objective: To determine the prevalence of anxiety, depression and burnout in residents of Gynecology and Obstetrics during COVID-19 pandemic in Brazil and its associated factors. Methods: Cross-sectional study involving all regions of Brazil, through the application of a sociodemographic questionnaire, the Hospital Anxiety and Depression Scale (HAD) and the Maslach Burnout Inventory (MBI-HSS) instrument. Multivariate analysis was performed after adjusting the Poisson model. Results: Among the 719 participating medical residents, screening was positive for anxiety in 75.7% and for depression in 49.8% of cases. Burnout syndrome was evidenced in 41.3% of the physicians studied. Those with depression are more likely to have anxiety (OR 0.797; 95%CI 0.687 - 0.925) and burnout syndrome (OR 0.847 95%CI 0.74 - 0.97). Residents with anxiety (OR 0.805; 95%CI 0.699 - 0.928) and burnout (OR 0.841; 95%CI 0.734 - 0.963) are more likely to have depression. Conclusion: High prevalence of anxiety, depression and burnout were found in residents of Gynecology and Obstetrics in Brazil, in addition to important correlations between anxiety-depression and depression-burnout.

Ecografía realizada por cirujanos generales más allá de la evaluación enfocada al trauma / Echography Scans Performed by General Surgeons beyond Focused Assessment for Trauma

Introducción: La ecografía es considerada en la actualidad una modalidad de imagen establecida en medicina con múltiples beneficios que se utiliza ampliamente en la práctica quirúrgica. Los cirujanos son entrenados en exploraciones de Evaluación Ecográfica Enfocada para el Trauma. Sin embargo, cada vez adquieren más habilidades para realizar ecografías, tanto al lado de la cama como en el transoperatorio para otras presentaciones quirúrgicas. Objetivo: Exponer el uso de la ecografía realizada por el cirujano general ante el paciente quirúrgico. Métodos: Se realizó una revisión bibliográfica del tema en las bases de datos PubMed, BVS-BIREME y Cochrane. Se consideraron en la búsqueda todo tipo de estudios publicados desde enero de 1958 hasta enero del 2022, a los cuales se tuvo acceso. Los idiomas utilizados en la búsqueda fueron el español y el inglés. Desarrollo: La ecografía realizada por el cirujano general es cada vez más preconizada a nivel mundial, no solo para el trauma sino tanto en afecciones agudas intrabdominales como para aumentar la seguridad durante el transoperatorio. Conclusiones: La ecografía tiene muchas ventajas debido a que es una técnica segura, rápida, no invasiva, portátil y repetible, que brinda imágenes dinámicas en tiempo real relevantes para el manejo del paciente(AU)

Introduction: Echography is nowadays considered an established imaging modality in medicine and with multiple benefits, as well as widely used in surgical practice. Surgeons are trained in focused assessment with echography for trauma. However, they are becoming increasingly skilled in performing echography scans, both at the point of care and in the transoperative setting for other surgical presentations. Objective: To expose the use of echography performed by the general surgeon directly on the surgical patient. Methods: A bibliographic review of the subject was carried out in the PubMed, BVS-BIREME and Cochrane databases. All types of studies published from January 1958 to January 2022, to which access was available, were considered in the search. The languages used in the search were Spanish and English. Development: The echography scan performed by the general surgeon is increasingly advocated worldwide, not only for trauma but also for acute intraabdominal conditions, as well as to increase safety during the transoperative period. Conclusions: Echography has many advantages because it is a safe, fast, noninvasive, portable and repeatable technique that provides real-time dynamic images relevant to patient management(AU)

Prevalence and factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná / Prevalencia y factores asociados a la muerte de personas mayores hospitalizadas por Covid-19 en el estado de Paraná / Prevalência e fatores associados ao óbito de idosos hospitalizados por Covid-19 no estado do Paraná

ABSTRACT Objective: To estimate the prevalence and to analyze the factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná. Method: Cross-sectional study conducted with secondary data from older people with a positive diagnosis of Covid-19 living in the State of Paraná, collected from March 1, 2020 to August 31, 2021. Prevalence ratios were obtained by adjusting the regression model. Results: A total of 16,153 deaths of older people hospitalized in the State of Paraná were analyzed. The adjusted model revealed an association between death and some factors such as: belonging to the age group of 75 to 84 years (PR = 1.28; CI95% = 1.24-1.32) and 85 years or over (PR = 1.52; CI95% = 1.45-1.59); male (PR = 1.17; CI95% = 1.13-1.21); obesity (PR = 1.23; CI95% = 1.16-1.29); other morbidities (PR = 1.25; CI95% = 1.20-1.30); and having used ventilatory support (PR = 2.60; CI95% = 2.33-2.86). Older people vaccinated against influenza had a probability of death reduced by 11% (PR = 0.89; CI95% = 0.86-0.93). Conclusion: The association of age, sex, and diagnosis of previous comorbidities with unfavorable outcomes from Covid-19 was identified. Having received the flu vaccine provided protection to elderly people who contracted SARS-CoV-2.

RESUMEN Objetivo: Prevalencia y factores asociados a la muerte de personas mayores hospitalizadas por Covid-19 en el estado de Paraná* Método: Estudio transversal realizado con datos secundarios de personas mayores con diagnóstico positivo de Covid-19 residentes en el Estado de Paraná, recolectados del 1 de marzo de 2020 al 31 de agosto de 2021. Las razones de prevalencia se obtuvieron ajustando el modelo de regresión. Resultados: Se analizaron 16.153 muertes de personas mayores hospitalizadas en el Estado de Paraná. El modelo ajustado reveló asociación entre la muerte y algunos factores como: pertenecer al grupo etario de 75 a 84 años (RP = 1,28; IC95% = 1,24-1,32) y 85 años o más (RP = 1,52; IC95% = 1,45-1,59); masculino (RP = 1,17; IC95% = 1,13-1,21); obesidad (RP = 1,23; IC95% = 1,16-1,29); otras morbilidades (RP = 1,25; IC95% = 1,20-1,30); y haber utilizado soporte ventilatorio (RP = 2,60; IC95% = 2,33-2,86). Las personas mayores vacunadas contra la influenza tuvieron una probabilidad de muerte reducida en un 11% (RP = 0,89; IC95% = 0,86-0,93). Conclusión: Se identificó la asociación de la edad, el sexo y el diagnóstico de comorbilidades previas con resultados desfavorables por Covid-19. Haber recibido la vacuna contra la gripe brindó protección a las personas mayores que contrajeron el SARS-CoV-2.

RESUMO Objetivo: Estimar a prevalência e analisar os fatores associados ao óbito de idosos hospitalizados por Covid-19 no Estado do Paraná. Método: Estudo transversal conduzido com dados secundários de idosos com diagnóstico positivo de Covid-19 residentes no Estado do Paraná, coletados no período de 01 de março de 2020 a 31 de agosto de 2021. As razões de prevalências foram obtidas por meio do ajuste de modelo de regressão. Resultados: Foram analisados 16.153 óbitos de idosos hospitalizados no Estado do Paraná. O modelo ajustado revelou associação do óbito a alguns fatores como: pertencer a faixa etária dos 75 a 84 anos (RP = 1,28; IC95% = 1,24-1,32) e 85 anos ou mais (RP = 1,52; IC95% = 1,45-1,59); sexo masculino (RP = 1,17; IC95% = 1,13-1,21); obesidade (RP = 1,23; IC95% = 1,16-1,29); outras morbidades (RP = 1,25; IC95% = 1,20-1,30); e ter utilizado suporte ventilatório (RP = 2,60; IC95% = 2,33-2,86). Idosos vacinados contra a gripe tiveram probabilidade de morte reduzida em 11% (RP = 0,89; IC95% = 0,86-0,93). Conclusão: Identificou-se a associação da idade, sexo e diagnóstico de comorbidades prévias aos desfechos desfavoráveis da Covid-19. Ter recebido o imunizante contra a gripe conferiu proteção aos idosos que contraíram o SARS-CoV-2.

Bleaching gel volume influences hydrogen peroxide diffusion, inflammation, and the presence of nitric oxide in the pulp tissue: in vitro and in vivo model

Abstract Objective To assess whether bleaching gel volume influences chromatic changes, hydrogen peroxide (HP) diffusion, inflammation, and oxidative stress in the pulp tissue. Methodology A total of 60 bovine teeth were divided into four groups, according to bleaching gel volume (n=15): without gel (WG); V30 (30 µL of 35% HP); V60 (60 µL); and V120 (120 μL). HP diffusion analysis was performed in the first session (T1). Chromatic changes (ΔE, ΔE00, and WID) were assessed after the first (T1), second (T2), third (T3) sessions, and 15 d (T4) after the end of treatment. Moreover, 20 rats were randomly divided into four groups (n=10) and their upper first molars were treated with different gel volumes: control (no treatment); V2 (2 μL of 17.5% HP); V4 (4 μL); and V8 (8 μL). After 24 h, rats were euthanized and the specimens processed for histological and immunohistochemical (nitric oxide synthase) evaluation. Data were analyzed using the Wilcoxon and Mann-Whitney tests (p<0.05). Results In vitro (bovine teeth), chromatic changes were not influenced by bleaching gel volume, showing similar values in all groups and sessions, except for the control group (p<0.05). The V120 group had the highest HP diffusion values (p<0.05). In vivo (pulp tissue), the V4 and V8 groups showed the highest inflammatory infiltrate in the pulp and significant oxidative stress (p<0.05). Conclusion The adverse effects on the dental pulp related to HP diffusion, pulp inflammation, and oxidative stress depend on bleaching gel volume, while the bleaching effect is not proportional to the volume used.

Factors associated with early weaning and spatial pattern of breastfeeding in territory in the Zona da Mata of Pernambuco, Brazil / Fatores associados ao desmame precoce e padrão espacial do aleitamento materno em território na Zona da Mata de Pernambuco, Brasil

Abstract Objectives: to assess factors associated with early weaning and the pattern of spatial distribution of breastfeeding in the ascription territory of a Basic Health Unit (BHU). Methods: analytic cross-sectional study performed with 47 mothers of children under 2 years of age in a BHU from Vitória de Santo Antão, Pernambuco. The association of independent variables and early weaning was verified using bivariate and multivariate analysis. For spatial analysis of cases of breastfeeding, we applied Kernel density estimation, proximity analysis buffers of the addresses of participants to the Health Unit and flow map. Results: the prevalence of early weaning was 61.7% (CI95% = 47.8-75.6). Factors associated with early weaning were: distance of residence to the BHU higher than 500 meters, not being primiparous, non-participation in educational groups for pregnant women during prenatal period and use of nursing bottles. Being beneficiary of welfare program Bolsa Família and residing in a home with piped water constituted a protective factor for this outcome. Two clusters of early weaning cases were found in locations further away from the BHUs. Conclusions: there was high prevalence of early weaning and association of this outcome with the home-health unit displacement, being primiparous, non-participation of pregnant women in educational activities during prenatal period and use of nursing bottles.

Resumo Objetivos: avaliar os fatores associados ao desmame precoce e o padrão de distribuição espacial do aleitamento materno no território de adscrição de uma Unidade Básica de Saúde (UBS). Métodos: estudo analítico transversal realizado com 47 mães de crianças menores de dois anos em uma UBS, de Vitória de Santo Antão, Pernambuco. A associação entre as variáveis independentes e o desmame precoce foi verificada por meio de análise bivariada e multivariada. Para análise espacial dos casos de aleitamento materno, empregou-se a técnica de densidade de Kernel, buffers de proximidade dos endereços das participantes à Unidade de Saúde e mapa de fluxo. Resultados: a prevalência de desmame precoce foi de 61,7% (IC95%= 47,8-75,6). Os fatores associados ao desmame precoce foram: distância da residência para a UBS maior de 500 metros, não ser primípara, não participação no grupo educativo de gestante durante o pré-natal e o uso de mamadeira. Receber bolsa família e residir em domicílio com água encanada constituíram fator de proteção a esse desfecho. Encontrou-se dois aglomerados de casos de desmame precoce em locais mais afastados da UBS. Conclusões: houve alta prevalência de desmame precoce e associação deste desfecho com o deslocamento domicílio-unidade de saúde, primiparidade, não participação da gestante em atividades educativas durante o pré-natal e utilização de mamadeira.

Feasibility of a snowball sampling survey to study active surveillance for thyroid microcarcinoma treatment among endocrinologists and surgeons of Brazil

Abstract Objectives: This study aims to investigate if a sampling method using virtual networks is feasible to survey AS adoption among this "hard-to-reach" population of Brazilian doctors. Methods: An online piloted 11-point structured survey questionnaire (designed using Googleforms®) probed the actual treatment patterns for adult patients with PTMCs, including treatment decision-making nonoperative options, was undertaken between 10 November and 30 November 2020. Participants were reached by the mobile phone Application (APP) and a snowball sampling strategy was used to recruit a total of 4783 members (maximum number of potential reach), which is the total of doctors of the all 21 social media WhatsApp® groups. Results: From a total of 4783 members (maximum number of potential reach), there were 657 (13.7%) doctors (actual reach) who clicked the web link of the questionnaire, out of whom 512 (10.7%) fully completed the online survey. Among the survey respondents, 361 were endocrinologists (70.5%) and 151 were surgeons (29.5%). Overall, for low-risk PTMCs in an elderly patient, 118 responders (23%) recommend AS, while 390 (76%) recommend immediate surgery as the management, including lobectomy (18.5%) and Total Thyroidectomy (58.2%). The present responders tended to recommend surgery for PTMCs that were located adjacent to the dorsal surface of the thyroid, were multiple, or raised the size during the follow-up. Conclusion: Using snowball sampling strategy as an innovative route to conduct surveys was feasible and applicable but the rate of response was still very low. Our data also suggests the need to investigate if AS is embraced by Brazilian doctors.

Midias sociais para atração de pacientes em clínicas odontológicas privadas durante pandemia de Covid 19 / Social media for attracting patients in private dental clinics during the Covid 19 pandemic

Verificar a rotina dos cirurgiões-dentistas (CD) e a utilização das mídias sociais, como meio de divulgação profissional e de atração de pacientes em clínicas odontológicas privadas, durante a pandemia de Covid-19. Este estudo transversal qualitativo inclui questionários respondidos por CD atuantes em clínicas privadas na região sudeste do Brasil. Um questionário virtual, elaborado através da plataforma Google Forms, abordou informações sobre o perfil dos profissionais e os aspectos dos métodos publicitários e mídias sociais utilizados para o alcance de pacientes durante o período de pandemia de Covid-19. Os dados obtidos foram tabulados e submetidos à análise estatística descritiva (%). No total, 102 CD participaram do estudo, sendo que 96 questionários seguiram os critérios de inclusão para a análise dos dados. A divulgação social como meio de exposição profissional foi uma ação realizada por 75 (78,13%) CD da amostra. Considerando esses profissionais, 74 (98,67%) utilizam redes sociais e domínios virtuais para tal finalidade, sendo que 71 (95,95%) CD usufruem do Instagram. Grande parte dos participantes (71,62%) relatou não possuir assessoria de marketing especializada para fazer publicações de conteúdo profissional nas redes sociais, embora a maioria publique este tipo de conteúdo mais de uma vez por semana (58,11%). Uma grande parcela dos participantes do estudo (67,71%) notou que a pandemia de Covid-19 procovou diminuição na quantidade de pacientes nas clínicas odontológicas. A inclusão de outros equipamentos de proteção individual foi a conduta mais seguida pelos CD (56,25%) para evitar a transmissão da doença neste período. Conclui-se que os CD participantes acreditam que a pandemia de Covid-19 promoveu um impacto negativo na atração de pacientes em clínicas odontológicas privadas na região sudeste brasileira, ainda que a maioria destes profissionais tenham incluído outros equipamentos de proteção individual como medida de segurança e utilizem frequentemente redes sociais para divulgação de conteúdo profissional, tendo o Instagram como a principal mídia social. No entanto, a assessoria de marketing especializada em publicações de conteúdo profissional nas redes sociais ainda é um recurso pouco utilizado no meio odontológico(AU)

To verify the routine of Dental Surgeons (DS) and the use of social media as a means of professional dissemination and patient attraction in private dental clinics during the Covid-19 pandemic. This cross-sectional qualitative study included questionnaires answered by Dental Surgeons working in private clinics in the southeastern region of Brazil. A virtual questionnaire, which was developed through the Google Forms platform, addressed information about the profile of professionals and aspects of advertising methods and social media used to reach patients during the Covid-19 pandemic period. The data were tabulated and submitted to descriptive statistical analysis (%). A total of 102 Dental Surgeons participated in the study, with 96 questionnaires meeting the inclusion criteria for data analysis. Social disclosure as a means of professional exposure was an action performed by 75 (78.13%) Dental Surgeons of the survey. Considering these professionals, 74 (98.67%) use social networks and virtual domains for this purpose and 71 (95.95%) Dental Surgeons use Instagram. A large portion of the participants (71.62%) reported not having a specialized marketing consultancy to make professional contente publications on social media, although most publish this type of content more than once a week (58.11%). A large portion of study participants (67.71%) noted that the Covid-19 pandemic caused a decrease in the amount of patients in the dental clinics. The inclusion of other personal protective equipment was the conduct most followed by the Dental Surgeons (56.25%) to avoid the transmission of the disease in this period. It can be concluded that the participating Dental Surgeons believe that the Covid-19 pandemic promoted a negative impact on attracting patients in private dental clinics in the southeastern region of Brazil, in spite of most of these professionals have included other personal protective equipment as safety measure and frequently use social networks for dissemination of professional content, with Instagram as main social media. However, a marketing consultancy specialized in publishing professional content on social networks is still a resource which is little used in the dental environment(AU)

Vitamin D metabolism and extraskeletal outcomes: an update

ABSTRACT Vitamin D deficiency is a general health problem affecting individuals at all stages of life and on different continents. The musculoskeletal effects of vitamin D are well known. Its deficiency causes rickets, osteomalacia, and secondary hyperparathyroidism and increases the risk of fractures. Clinical and experimental evidence suggests that vitamin D performs multiple extraskeletal functions. Several tissues unrelated to calcium and phosphate metabolism express vitamin D receptor (VDR) and are directly or indirectly influenced by 1,25(OH)2D (calcitriol). Some also express the enzyme 1 alpha-hydroxylase (CYP27B1) and produce 1,25(OH)2D, inducing autocrine or paracrine effects. Among the pleiotropic effects of vitamin D are the regulation of cell proliferation and differentiation, hormone secretion, and immune function. In this review, we outline vitamin D physiology and the outcomes of recent large RCTs on its potential extraskeletal effects. Those studies exhibit a need for continued clinical analysis to elucidate whether vitamin D status can influence extraskeletal health. Longer longitudinal follow-up and standardized assays are crucial to better assess potential outcomes.

O IMPACTO DA PANDEMIA COVID-19 NA EDUCAÇÃO FÍSICA ESCOLAR: uma revisão integrativa da literatura / THE IMPACT OF PANDEMIC COVID-19 ON SCHOOL PHYSICAL EDUCATION: an integrative literature review / EL IMPACTO DE LA PANDEMIA COVID-19 EN LA EDUCACIÓN FÍSICA ESCOLAR: una revisión integrativa de la literatura

A pandemia da COVID-19 trouxe alterações na vida das pessoas. O presente estudo, que foca no âmbito escolar, tem por objetivo verificar quais os impactos da pandemia para alunos de Ensino Fundamental. Realizou-se uma revisão integrativa da literatura, utilizando os descritores: "educação"; "educação física"; "escola"; "pandemia"; "COVID-19" nas bases de dados Scielo, BVS e PubMed. Descreve-se os impactos que a pandemia causou nos alunos: diminuição da prática de exercício físico e falta de estrutura no ambiente domiciliar; dificuldades de acesso às aulas remotas; maior ansiedade e prejuízos sociais. Recomenda-se intervenções dos profissionais de Educação Física e das autoridades públicas para que se reduza os efeitos prejudiciais desse período.

The COVID-19 pandemic brought changes in people's lives, and the focus of the present study is on the school setting. The aim was verify the impacts of the pandemic for elementary school students. An integrative literature review was carried out, using the descriptors: "education"; "physical education"; "school"; "pandemic"; "COVID-19" in the databases Scielo, BVS and PubMed. It was described the impacts that the pandemic caused on students: decreased physical exercise and lack of structure in the home environment, difficulties in accessing remote classes, greater anxiety and social damage. Interventions by Physical Education professionals and public authorities are recommended to reduce the harmful effects of this period.

La pandemia de COVID-19 trajo cambios en la vida de las personas y el presente estudio se centra en el entorno escolar. El objetivo fue verificar los impactos de la pandemia para los estudiantes de primaria. Se realizó una revisión integradora de la literatura, utilizando los descriptores: "educación"; "educación Física"; "colegio"; "pandemia"; "COVID-19" en las bases de datos Scielo, BVS y PubMed. Se describen los impactos que la pandemia provocó en los estudiantes: disminución del ejercicio físico y falta de estructura en el ambiente del hogar, dificultades para acceder a clases remotas, mayor ansiedad y daño social. Se recomiendan las intervenciones de los profesionales de la Educación Física y las autoridades públicas para reducir los efectos nocivos de este período.

Efficiency of electrocoagulation in the treatment of laundromat greywater / Tratamento por eletrofloculação de efluentes oriundos de lavandeiras domésticas

ABSTRACT The high consumption of water and the generation of greywater in laundromats underscore the need to investigate advanced treatment techniques to reuse this effluent. Based on the estimated growth figures of the laundromat sector in Brazil, this study looked into the efficiency of electrocoagulation to treat laundromat greywater. Electrodes were connected to an EC reactor on a monopolar parallel connection mode, with electric current of 6 A and current density of 400 A.m2. The highest efficiency to treat laundromat greywater was observed at a distance of 15 mm between electrodes, voltage of 17.14 V, and operation time of 30 min, when the removal values of apparent color, true color, turbidity, biochemical oxygen demand, chemical oxygen demand, and surfactants were 92, 97, 88, 91, 98, and 96%, respectively. Electrode consumption was measured at 1.82 g.h, while energy consumption was 20.54 kWh.m3 and the total cost was US$ 4.10 per cubic meter of treated effluent. However, despite the high efficiency of the treatment, reuse of treated laundromat effluent requires polishing in order to meet the standards defined by Brazilian regulations.

RESUMO O elevado consumo de água potável e a consequente geração de efluentes associados ao segmento de lavanderias domésticas justificam o estudo de tratamentos avançados que proporcionem o reuso dessas águas. Considerando-se uma perspectiva de crescimento desse setor em nível nacional, esta pesquisa avaliou a eletrocoagulação como tecnologia de tratamento de tais efluentes. Foram executados testes de bancada utilizando eletrodos em alumínio, arranjados como monopolar paralelo. A corrente elétrica e a densidade de corrente foram fixadas em 6A e 400A.m², respectivamente. Entre as variáveis avaliadas estão a distância entre eletrodos, o tempo de operação, o tipo de roupa, a utilização de alvejante e o suporte para eletrólise. O melhor tratamento foi obtido sem a utilização do suporte para eletrólise, para uma distância entre eletrodos de 15 mm, tensão elétrica aplicada no sistema de 17,14 V e tempo de operação igual a 30 min. Nessas condições, as eficiências do tratamento obtidas foram de 92% para cor aparente, 97% para cor verdadeira, 88% para turbidez, 91% para demanda bioquímica de oxigênio, 98% para demanda química de oxigênio e 96% para surfactantes. O sistema resultou no consumo de eletrodo de 1,83 g.h e no consumo de energia elétrica igual a 20,57 kWh.m³. O custo final do tratamento foi calculado em US$ 4,10.m³ de efluente tratado. Embora tenham sido obtidas elevadas remoções nas concentrações dos poluentes, para o reuso do efluente ainda é necessário um tratamento adicional.

O impacto da pandemia Covid-19 na Educação Física escolar uma revisão integrativa da literatura / THE IMPACT OF PANDEMIC COVID-19 ON SCHOOL PHYSICAL EDUCATION: an integrative literature review / EL IMPACTO DE LA PANDEMIA COVID-19 EN LA EDUCACIÓN FÍSICA ESCOLAR: una revisión integrativa de la literatura

A pandemia da COVID-19 trouxe alterações na vida das pessoas. O presente estudo, que foca no âmbito escolar, tem por objetivo verificar quais os impactos da pandemia para alunos de Ensino Fundamental. Realizou-se uma revisão integrativa da literatura, utilizando os descrito-res: "educação"; "educação física"; "escola"; "pandemia"; "COVID-19" nas bases de dados Scielo, BVS e PubMed. Descreve-se os impactos que a pandemia causou nos alunos: diminuição da prática de exercício físico e falta de estrutura no ambiente domiciliar; dificuldades de acesso às aulas remotas; maior ansiedade e prejuízos sociais. Recomenda-se intervenções dos profissionais de Educação Física e das autoridades públicas para que se reduza os efeitos prejudiciais desse período (AU).

The COVID-19 pandemic brought changes in people's lives, and the focus of the present study is on the school setting. The aim was verify the impacts of the pandemic for elementary school students. An integrative literature review was carried out, using the descriptors: "education"; "physical education"; "school"; "pandemic"; "COVID-19" in the databases Scielo, BVS and PubMed. It was described the impacts that the pandemic caused on students: decreased physical exercise and lack of structure in the home environment, difficulties in accessing remote classes, greater anxiety and social damage. Interventions by Physical Education professionals and public authorities are recommended to reduce the harmful effects of this period (AU).

La pandemia de COVID-19 trajo cambios en la vida de las personas y el presente estudio se centra en el entorno escolar. El objetivo fue verificar los impactos de la pandemia para los estudiantes de primaria. Se realizó una revisión integradora de la literatura, utilizando los descriptores: "educación"; "educación Física"; "colegio"; "pandemia"; "COVID-19" en las bases de datos Scielo, BVS y PubMed. Se describen los impactos que la pandemia provocó en los estudiantes: disminución del ejercicio físico y falta de estructura en el ambiente del hogar, dificultades para acceder a clases remotas, mayor ansiedad y daño social. Se recomiendan las intervenciones de los profesionales de la Educación Física y las autoridades públicas para reducir los efectos nocivos de este período (AU).

Evaluation of the histological and immunohistochemical subtype of breast cancer patients from a referral hospital in the inland of the state of São Paulo

Introduction: The immunohistochemical markers used in breast cancer cases allow the classification of tumors into four subtypes: luminal A (1), luminal B (2), HER2 positive (3), and triple-negative or basal-like (4). This study aimed to evaluate the histological and immunohistochemical profile of breast cancer patients from a referral hospital in the inland of the state of São Paulo and understand the particularities of the prognosis based on the tumor-node-metastasis staging. Methods: This retrospective observational epidemiological cohort study was carried out at Hospital Regional de Presidente Prudente, with the first half of 2020 as the time frame. The research target population was women diagnosed with breast cancer who underwent immunohistochemical examination. We excluded patients with breast carcinoma in situ and incomplete medical records, which made data analysis impossible. After classifying the cases into four molecular subtypes based on immunohistochemistry, identifying the histological grade, and verifying the pathological staging criteria, we gathered the data and addressed the pathological-prognostic staging to investigate the prognosis of each patient. Results: We analyzed 49 patients with a complete immunohistochemical profile. Among them, luminal A (44.9%) was the most prevalent molecular subtype, followed by luminal B (36.7%). The least prevalent subtypes were triple-negative (16.8%) and HER2 (2%). Pathological-prognostic staging was possible in 73.5% of cases. Conclusions: The molecular subtype is important for tumor evaluation and has direct implications for the staging of breast cancer patients.

Undernutrition and obesity trends in Brazilian adults from 1975 to 2019 and its associated factors / Tendências de subnutrição e obesidade em adultos brasileiros entre 1975 e 2019 e fatores associados / Tendencias de desnutrición y obesidad en adultos brasileños desde 1975 a 2019 y sus factores asociados

Nutritional status has evolved in a dual trend worldwide: underweight has become a minor or local issue while overweight or obesity has risen to play a major role in the global burden of disease. In 2014, Brazil was ranked as the third country with the highest absolute number of obese men. Our aim was to estimate trends of underweight and obesity among Brazilian adults using a comprehensive set of surveys from 1974 to 2019. The data used in the study originate from subjects aged ≥ 18 in six Brazilian national surveys, presented in chronological order: Brazilian National Survey on Household Expenses (ENDEF 1974-1975); Brazilian National Survey on Health and Nutrition (PNSN 1989); Brazilian Household Budget Survey (POF 2002-2003, 2008-2009); and Brazilian National Health Survey (PNS 2013 and 2019). All six surveys were designed to sample household complexes that were representative of the Brazilian population. Body mass index was calculated (kg/m2). The nutritional status of individuals was classified following the standards. We have modeled obesity trend according to income and education strata. The trajectories of underweight and obesity over time in Brazil draw the classical "X" of nutrition transition. From 1975 to 2019 underweight has decreased from 9.1% to 2.5% among men and 12.2% to 3.4% among women. On the other hand, obesity trajectories have scaled up from 3% to 22% among men and from 9% to 30% among women. The increase in obesity rate is directly and negatively proportional to income quintiles. Sociodemographic (income and education) improvement is associated with an increase in obesity. All public policies intending to stop the obesity spread in Brazil have been ineffective or too small to be effective.

O estado nutricional tem evoluído em duas direções no mundo: o baixo peso se tornou uma questão menor ou local, enquanto o sobrepeso ou obesidade passou a ter papel preponderante na carga global de doença. Em 2014, o Brasil ocupou terceiro lugar no mundo em número absoluto de homens obesos. O estudo teve como objetivo estimar as tendências nas taxas de baixo peso e obesidade entre adultos brasileiros, tendo como base um conjunto abrangente de inquéritos entre 1974 e 2019. Os dados utilizados no estudo se referem a indivíduos com 18 anos ou mais em seis pesquisas nacionais, apresentadas em ordem cronológica: Estudo Nacional de Despesa Familiar (ENDEF 1974-1975); Pesquisa Nacional sobre Saúde e Nutrição (PNSN 1989); Pesquisa de Orçamentos Familiares (POF 2002-2003, 2008-2009) e Pesquisa Nacional de Saúde (PNS 2013 e 2019). Todos os 6 inquéritos foram desenhados para obter amostras de complexos de domicílios que fossem representativas da população brasileira. O ídice de massa corporal foi calculado (kg/m2). O estado nutricional dos indivíduos foi classificado de acordo com as normas da Organização Mundial da Saúde. Modelamos a tendência da obesidade de acordo com as faixas de renda e escolaridade. As trajetórias de baixo peso e obesidade no Brasil ao longo do tempo mostram a forma clássica em "X" da transição nutricional. Entre 1975 e 2019, a taxa de baixo peso diminuiu de 9,1% para 2,5% entre homens e de 12,2% para 3,4% entre mulheres. Inversamente, as trajetórias da obesidade aumentaram de 3% para 22% entre homens e de 9% para 30% entre mulheres. O incremento na obesidade está relacionado diretamente e de maneira negativamente proporcional aos quintis de renda. A melhoria sociodemográfica (de renda e escolaridade) está associada ao aumento da obesidade. Todas as políticas públicas para interromper a expansão da obesidade no Brasil têm sido ineficazes, ou pequenas demais para ser eficazes.

El estatus nutricional ha evolucionado en una doble tendencia alrededor del mundo: el bajo peso se ha convertido en un problema menor o local, mientras que el sobrepeso o la obesidad ha aumentado desempeñando un papel importante en la carga global de la enfermedad. En 2014, Brasil se situó como el tercer país con la mayor carga absoluta de hombres obesos. Nuestro objetivo fue estimar las tendencias de bajo peso y obesidad entre brasileños adultos, utilizando un conjunto completo de encuestas desde 1974 a 2019. Los datos usados en el estudio procedieron de individuos con ≥18 años en 6 encuestas nacionales brasileñas, presentadas en orden cronológico: Estudio Nacional sobre Gasto Familiar (ENDEF 1974-1975); Encuesta Nacional de Salud y Nutrición (PNSN 1989); Encuestas sobre Presupuesto Familiar (POF 2002-2003, 2008-2009); y Encuesta Nacional de Salud (PNS 2013 y 2019). Las 6 encuestas se diseñaron para las muestras complejas de hogares que eran representativas de la población brasileña. Se calculó el indice de masa corporal (kg/m2). El estatus nutricional de los individuos se clasificó siguiendo los estándares de la Organización Mundial de la Salud. Hemos modelado la tendencia a la obesidad según el nivel de ingresos y educación. Las trayectorias de bajo peso y obesidad a lo largo del tiempo en Brasil dibujaron la clásica "X" de transición nutricional. Desde 1975 a 2019, ha decrecido el bajo peso de 9,1% a 2,5% entre hombres y de 12,2% a 3,4% entre mujeres. Las trayectorias de obesidad, en cambio, escalan desde el 3% al 22% entre hombres, y desde el 9% al 30% entre mujeres. El incremento en la tasa de obesidad es directamente y negativamente proporcional a los quintiles de ingresos. La mejora sociodemográfica (ingresos y educación) está asociada con un incremento en la obesidad. Todas las políticas públicas puestas en práctica para intentar detener la propagación de la obesidad en Brasil han sido inefectivas o demasiado pequeñas para ser efectivas.

Análise de Força Muscular e Mobilidade de Pacientes com Câncer Hematológico Atendidos pela Fisioterapia em um Centro de Assistência de Alta Complexidade em Oncologia / Analysis of Muscle Strength and Mobility of Patients with Hematologic Cancer Consulted at Physiotherapy in a High Complexity Oncology Clinic / Análisis de Fuerza Muscular y Movilidad de Pacientes con Cáncer Hematológico Atendidos por Fisioterapia en un Centro de Atención de Alta Complejidad en Oncología

Introdução: Câncer é o nome dado a um conjunto de mais de 100 doenças, caracterizado pelo crescimento anormal e acelerado de células, podendo ser considerado sólido ou hematológico. As neoplasias hematológicas levam a alterações específicas que podem contribuir para a inatividade, principalmente pelo alto risco de sangramento, induzindo perdas funcionais, tornando importante a realização da fisioterapia para prevenir ou minimizar essas perdas. Objetivo: Analisar a força muscular e a mobilidade de pacientes com câncer hematológico internados em um hospital de referência do Distrito Federal. Método: Estudo quantitativo, retrospectivo e longitudinal. A coleta foi realizada a partir de dados secundários de prontuários eletrônicos e planilhas de acompanhamento da fisioterapia, abrangendo o período de junho a dezembro de 2020. Foram analisadas a força muscular, por meio da dinamometria manual e da escala Medical Research Council (MRC), e a mobilidade, por meio da ICU Mobility Scale (IMS). Resultados: Dos 86 indivíduos rastreados, 43 foram elegíveis para a pesquisa. A análise entre a admissão e a alta hospitalar não revelou diferenças significativas na força muscular e mobilidade. Houve associação moderada e significativa entre MRC e IMS na admissão (r=0,575 and p<0.001) and at discharge (r=0.481 and p=0.001). No significant associations between dynamometry and mobility were found. Conclusion: This study allowed the identification of the profile of onco-hematological patients in follow-up, suggesting that physiotherapy contributed to maintain the functionality of these patients

Introduction: Cancer is the name given to a set of more than 100 diseases characterized by abnormal and accelerated growth of cells, and can be considered solid or hematological. Hematological neoplasms lead to specific changes that can contribute to inactivity, mainly due to the high risk of bleeding, inducing functional losses, being important to perform physical therapy to prevent or minimize these losses. Objective: Analyze the muscle strength and mobility of patients with hematological cancer admitted to a reference hospital in the Federal District. Method: Retrospective, quantitative longitudinal study. The collection was performed with secondary data from electronic medical records and physical therapy monitoring spreadsheets from June to December 2020. Muscle strength was analyzed using manual dynamometry and also with the Medical Research Council scale (MRC) and mobility by the ICU Mobility Scale (IMS). Results: Of the 86 individuals screened, 43 were eligible for the study. No significant differences were noticed in muscle strength and mobility in an analysis from admission to hospital discharge. There was a moderate and significant association between MRC and IMS at admission (r=0.575 and p<0.001) and at discharge (r=0.481 and p=0.001). No significant associations between dynamometry and mobility were found. Conclusion: This study allowed the identification of the profile of onco-hematological patients in follow-up, suggesting that physiotherapy contributed to maintain the functionality of these patients

Introducción: Cáncer es el nombre que se le da a un conjunto de más de 100 enfermedades, caracterizado por un crecimiento normal y acelerado de células, y puede ser considerado sólido o hematológico. Las neoplasias hematológicas conllevan alteraciones específicas que pueden contribuir a la inactividad, principalmente por el alto riesgo de hemorragia, induciendo pérdidas funcionales, haciendo que la fisioterapia sea importante para prevenir o minimizar estas pérdidas. Objetivo: Analizar la fuerza muscular y la movilidad de pacientes con cáncer hematológico, ingresados en un hospital de referencia del Distrito Federal de Brasil. Método: Estudio cuantitativo, retrospectivo y longitudinal. La recolección se realizó a partir de historias clínicas electrónicas y planillas de seguimiento de fisioterapia, abarcando el período de junio a diciembre de 2020. Se analizó la fuerza muscular, mediante la dinamometría manual y la escala Medical Research Council (MRC), y la movilidad, mediante la escala ICU Mobility Scale (IMS). Resultados: De las 86 personas seleccionadas, 43 fueron elegibles para la investigación. En el análisis entre el ingreso y el alta hospitalaria no se observaron diferencias significativas en la fuerza muscular y la movilidad. Hubo una asociación moderada y significativa entre el MRC e el IMS al ingreso (r=0,575 y p<0,001) y al alta (r=0,481 y p=0,001). No hubo asociaciones significativas entre la dinamometría y la movilidad. Conclusión:Este estudio permitió identificar el perfil de los pacientes onco-hematológicos seguidos, sugiriendo la contribución de la fisioterapia al mantenimiento de la funcionalidad de estos pacientes

Perda, luto e resiliência na pandemia de COVID-19: implicações para a prática com famílias / Loss, grief and resilience amid the COVID-19 pandemic: implications for practice with families

O presente estudo aborda perda, luto e resiliência na pandemia de COVID-19, apresentando considerações sobre a prática sistêmica com famílias. Trata-se de uma revisão narrativa da literatura nacional e internacional, em que foram sumarizados achados empíricos e recomendações para intervenções clínicas, com base na perspectiva sistêmica, face às demandas emergentes no atual contexto e à noção de experiência coletiva. Foram discutidas as múltiplas perdas associadas à COVID-19, as quais impactam estilos de vida, padrões de comportamento e interação, normas culturais e práticas relativas ao processo de morrer e à morte, aumentando potencialmente o risco de luto complicado, durante e após a pandemia. Enfatizou-se também o desenvolvimento adaptativo em meio às circunstâncias difíceis, com destaque à noção de resiliência familiar e a possíveis formas de promovê-la, incluindo a terapia familiar. Ademais, foram abordadas algumas das particularidades do processo clínico junto a famílias que experienciaram perdas na pandemia, incluindo recursos que podem ser utilizados pelo terapeuta, bem como desafios comumente vivenciados pelos profissionais nesse cenário.

The current study addresses loss, grief, and resilience amid the COVID-19 pandemic, presenting implications for systemic practice with families. This is a narrative review of the national (Brazilian) and international literature, in which empirical findings and recommendations for clinical interventions have been summarized, based on a systemic perspective, given the emerging demands in the current scenario and the notion of collective experience. We have discussed the multiple losses associated with COVID-19, which have an impact on lifestyles, patterns of behavior and interaction, and cultural norms and practices related to the process of death and dying, potentially increasing the risk of complicated grieving processes, during and after the outbreak. Adaptive development amid difficult circumstances have also been highlighted, with emphasis on the notion of family resilience and possible ways of promoting it, including family therapy. Furthermore, some of the particularities of the clinical process with families who experienced losses during the pandemic have been addressed, including resources that can be used by the therapist, as well as challenges commonly experienced by professionals in this scenario.

Avaliação da Força Muscular em Adultos com Hemofilia de uma Associação de Pacientes em Brasília / Assessment of Muscle Strength in Adults with Hemophilia from an Association of Patients in Brasília / Evaluación de la fuerza muscular en adultos con hemofilia de una asociación de pacientes en Brasilia

Objetivo: avaliar a força muscular periférica em adultos portadores de hemofilia, por meio da dinamometria manual, e verificar a diferença da força muscular de acordo com a classificação de gravidade da hemofilia. Método: Participaram da pesquisa 20 homens divididos em 2 grupos, um com hemofílicos e um controle; foi aplicada uma ficha avaliativa seguida do teste de preensão palmar. Resultados: Quando comparados os dois grupos, foi observada diferença estatística significativa nas variáveis estatura (p=0,007) e força de preensão dos lados dominante (p=0,04) e não dominante (0,002), favorecendo o grupo controle; quando comparada a força de preensão dos hemofílicos com a doença leve e grave, houve diferença significativa para o lado não dominante (p=0,01). Conclusão: Pode-se associar a diminuição de força de preensão para o grupo de hemofílicos à sua condição de doença crônica hereditária. Entretanto, como o número de participantes foi pequeno, esses resultados sugestivos, mostram a necessidade de mais estudos sobre o tema

Objective: to evaluate peripheral muscle strength in adults with hemophilia, through manual dynamometry, and to verify the difference in muscle strength according to the classification of hemophilia severity. Method: Twenty men participated in the research, divided into 2 groups, one with hemophiliacs and one control; an evaluation form was applied, followed by the handgrip test. Results: When the two groups were compared, a statistically significant difference was observed in the variables height (p=0.007) and grip strength of the dominant (p=0.04) and non-dominant (0.002) sides, favoring the control group; when comparing the grip strength of hemophiliacs with mild and severe disease, there was a significant difference for the non-dominant side (p=0.01). Conclusion: The decrease in grip strength for the group of hemophiliacs can be associated with their condition of hereditary chronic disease. However, as the number of participants was small, these suggestive results show the need for more studies on the subject.

Objetivo: El objetivo del estudio fue evaluar la fuerza muscular periférica en adultos con hemofilia, mediante dinamometría manual, y verificar la diferencia en la fuerza muscular según la clasificación de severidad de la hemofilia. Método: Participaron de la investigación 20 hombres, divididos en 2 grupos, uno con hemofílicos y otro control; Se aplicó un formulario de evaluación, seguido de la prueba de agarre. Resultados: Al comparar los dos grupos, se observó una diferencia estadísticamente significativa en las variables altura (p = 0,007) y fuerza de agarre en los lados dominantes (p = 0,04) y no dominantes (0,002), favoreciendo al grupo control; al comparar la fuerza de agarre de los hemofílicos con la enfermedad leve y grave, hubo una diferencia significativa para el lado no dominante (p = 0,01). Conclusión: La disminución de la fuerza de prensión del grupo de hemofílicos puede estar asociada a su condición de enfermedad crónica hereditaria. Sin embargo, como el número de participantes fue pequeño, estos sugerentes resultados muestran la necesidad de más estudios sobre el tema.

Risk factors for critical illness and death among adult Brazilians with COVID-19

Abstract INTRODUCTION: Severe acute respiratory syndrome coronavirus 2 has infected more than 9,834,513 Brazilians up to February 2021. Knowledge of risk factors of coronavirus disease among Brazilians remains scarce, especially in the adult population. This study verified the risk factors for intensive care unit admission and mortality for coronavirus disease among 20-59-year-old Brazilians. METHODS: A Brazilian database on respiratory illness was analyzed on October 9, 2020, to gather data on age, sex, ethnicity, education, housing area, and comorbidities (cardiovascular disease, diabetes, and obesity). Multivariate logistic regression analysis was performed to identify the risk factors for coronavirus disease. RESULTS: Overall, 1,048,575 persons were tested for coronavirus disease; among them, 43,662 were admitted to the intensive care unit, and 34,704 patients died. Male sex (odds ratio=1.235 and 1.193), obesity (odds ratio=1.941 and 1.889), living in rural areas (odds ratio=0.855 and 1.337), and peri-urban areas (odds ratio=1.253 and 1.577) were predictors of intensive care unit admission and mortality, respectively. Cardiovascular disease (odds ratio=1.552) was a risk factor for intensive care unit admission. Indigenous people had reduced chances (odds ratio=0.724) for intensive care unit admission, and black, mixed, East Asian, and indigenous ethnicity (odds ratio=1.756, 1.564, 1.679, and 1.613, respectively) were risk factors for mortality. CONCLUSIONS: Risk factors for intensive care unit admission and mortality among adult Brazilians were higher in men, obese individuals, and non-urban areas. Obesity was the strongest risk factor for intensive care unit admission and mortality.