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Acta cir. bras ; 31(11): 720-723, Nov. 2016. tab, graf
Article Dans Anglais | LILACS | ID: biblio-827662

Résumé

ABSTRACT PURPOSE: To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. METHODS: 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. RESULTS: This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). CONCLUSIONS: Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.


Sujets)
Animaux , Mâle , Rats , Lambeaux chirurgicaux , Pollution par la fumée de tabac/effets indésirables , Toxines botuliniques de type A/pharmacologie , Survie du greffon/effets des médicaments et des substances chimiques , Agents neuromusculaires/pharmacologie , Facteurs temps , Chlorure de sodium/administration et posologie , Répartition aléatoire , Rat Wistar , Toxines botuliniques de type A/administration et posologie , Diabète expérimental/complications , Injections , Agents neuromusculaires/administration et posologie
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