Protein-energy malnutrition increases teratogenicity of hypervitaminosis A in rats

The present study was designed to investigate the embryofetotoxicity of vitamin A in protein-energy malnourished animals. Retinyl palmitate (66, 99 and 132 mg/kg) suspendend in corn oil was given by gavage to well-nourished and malnourished rats from gestational days 8 to 10 and cesarean sections were performed on day 20. All fetuses were weighed and examined for malformations before being prepared for skeletal evaluation. The proportion of malformed fetuses was higher in the malnourished group at each one of the three dose levels. The data indicate that malnourished animals are more susceptible to the toxic effects of retinyl esters

Emprego de aglutinantes em comprimidos de hidroxido de alumínio em funçäo da liberaçäo dos princípios ativos / Use of agglutinants in aluminium hydroxide tablets in function of the active principles liberation

Este trabalho teve por objetivo fazer uma comparaçäo da velocidade de dissoluçäo do princípio ativo de comprimidos de Hidróxido de Alumínio, utilizando como aglutinantes: a goma arábica e a carboximetilcelulose sódica