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Int. braz. j. urol ; 41(5): 849-858, Sept.-Oct. 2015. tab, graf
Article Dans Anglais | LILACS | ID: lil-767051

Résumé

ABSTRACT Introduction and Objectives: Reactive Stroma (RStr) is observed in many human cancers and is related to carcinogenesis. The objectives of the present study were to stablish a relationship of the RStr microenvironment with prostate cancer (Pca) through a morphological and molecular characterization, and to identify a possible relationship between RStr with worse prognosis factors and occurrence of malignant prostatic stem cells. Materials and Methods: Forty prostatic samples were selected from men with Pca diagnosis submitted to radical prostatectomy; they were divided in two groups: Group-1 (n=20): samples without reactive stroma; Group-2 (n=20): samples of PCa with intense stroma reaction. Prostatic samples were evaluated for RStr intensity by Masson Trichromic stain and posteriorly submitted to histopathological and immunohistochemistry analysis for antigens: α-actin, vimentin, IGF-1, MMP-2, FGF-2, C-Myc, PSCA, AR, Erα and ERβ. Results: Reactive stroma with intense desmoplastic reactivity was significantly more frequent in intermediate (Gleason 7, 3+4) and high grade tumors (Gleason 7, 4+3). The group with intense stromal reactivity showed significant higher levels of Vimentin, IGF-1, MMP-2, FGF-2, C-Myc, PSCA and ERα. Conclusions: It can be concluded that RStr may be a predictive marker of Pca progression, since it was associated with increase of growth factors, imbalance of androgen and estrogen receptors and presence of malign prostatic stem cells.


Sujets)
Sujet âgé , Sujet âgé de 80 ans ou plus , Humains , Mâle , Adulte d'âge moyen , Adénocarcinome/anatomopathologie , Cellules épithéliales/anatomopathologie , Cellules souches tumorales/anatomopathologie , Tumeurs de la prostate/anatomopathologie , Cellules stromales/anatomopathologie , Actines/analyse , Adénocarcinome/composition chimique , Antigènes néoplasiques/analyse , Marqueurs biologiques tumoraux/analyse , Évolution de la maladie , Protéines de liaison à l'ADN/analyse , Cellules épithéliales/composition chimique , Récepteur alpha des oestrogènes/analyse , /analyse , Protéines liées au GPI/analyse , Immunohistochimie , Facteur de croissance IGF-I/analyse , /analyse , Grading des tumeurs , Protéines tumorales/analyse , Cellules souches tumorales/composition chimique , Tumeurs de la prostate/composition chimique , Cellules stromales/composition chimique , Microenvironnement tumoral , Facteurs de transcription/analyse , Vimentine/analyse
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