Effect of turpentine on alfa-1 major acute phase concentration in normal and adrenalectomized rats

Acute phase response of plasma alfa-1-major acute phase (alfa1-MAP) was studied in normal and adrenalectomized rats. Alfa1-MAP basal levels were higher in female than in male rats. This proteins, measured by radial immunodiffusion, increased significantly both in male and female rats 24 and 48 h after a turpentine stimulus, proving to be a positive acute phase protein for both sexes. In adrenalectomized male rats the increase of plasma alfa-1MAP concentration was not different from that observed in sham-operated rats, suggesting that the acute phase response of this protein is not corticoid dependent

Inflammatory edema induced by carrageenin in monosodium glutamate-treated rats

Rats treated with monosodium glutamate (MSG) during the neonatal period show hypothalamic lesions and multiple neuroendocrine alterations manifested as a remarkable increase in levels of circulating corticosterone and obesity. Paw edema induced by local injection of carrageenin was significantly reduced in MSG-treated rats compared to normal rats. In contrast, both adrenalectomized rats and adrenalectomized, MSG-treated rats showed an increased response to carrageenin relative to controls. These results suggest that glucocorticoids are important modulators of inflammation in this phase of the process