Résumé
Inclusion complex of plumbagin was prepared with betacyclodextrin employing neutralization method. The toxicity of the drug was reduced and the antitumor efficacy was enhanced on complexation with betacyclodextrin.
Sujets)
Absorption , Analyse de variance , Animaux , Antinéoplasiques d'origine végétale/administration et posologie , Cancérogènes/métabolisme , Carcinome d'Ehrlich/traitement médicamenteux , Cyclodextrines/métabolisme , Relation dose-effet des médicaments , Vecteurs de médicaments , Synergie des médicaments , Femelle , Dose létale 50 , Souris , Souris de lignée BALB C , Naphtoquinones/administration et posologie , Transplantation tumorale , Cyclodextrines bêtaRésumé
With a view to increase efficiency and reduce toxicity of Plumbagin, an attempt was made to formulate plumbagin as a controlled release preparation using various carriers and test for their antitumor and antifertility activities. Niosomes and albumin microspheres were used as carriers. In vitro data showed promising results for these formulations thus they were taken up for in vivo assessment. Given at a dose of 5 mg/kg, ip the albumin microspheres showed promising antitumor and antifertility activity when compared to the niosomes on control. Animal survival data also indicated slight improvement in survival rate and thus antitumoral activity. Also, an interesting point was that the antifertility activity was affected through an antiovulatory action as seen from histopathological studies.