Your browser doesn't support javascript.
loading
Montrer: 20 | 50 | 100
Résultats 1 - 2 de 2
Filtre
1.
Braz. j. med. biol. res ; 43(12): 1178-1183, Dec. 2010. ilus, tab
Article Dans Anglais | LILACS | ID: lil-569000

Résumé

Permanent bilateral occlusion of the common carotid arteries (2VO) in the rat has been established as a valid experimental model to investigate the effects of chronic cerebral hypoperfusion on cognitive function and neurodegenerative processes. Our aim was to compare the cognitive and morphological outcomes following the standard 2VO procedure, in which there is concomitant artery ligation, with those of a modified protocol, with a 1-week interval between artery occlusions to avoid an abrupt reduction of cerebral blood flow, as assessed by animal performance in the water maze and damage extension to the hippocampus and striatum. Male Wistar rats (N = 47) aged 3 months were subjected to chronic hypoperfusion by permanent bilateral ligation of the common carotid arteries using either the standard or the modified protocol, with the right carotid being the first to be occluded. Three months after the surgical procedure, rat performance in the water maze was assessed to investigate long-term effects on spatial learning and memory and their brains were processed in order to estimate hippocampal volume and striatal area. Both groups of hypoperfused rats showed deficits in reference (F(8,172) = 7.0951, P < 0.00001) and working spatial memory [2nd (F(2,44) = 7.6884, P < 0.001), 3rd (F(2,44) = 21.481, P < 0.00001) and 4th trials (F(2,44) = 28.620, P < 0.0001)]; however, no evidence of tissue atrophy was found in the brain structures studied. Despite similar behavioral and morphological outcomes, the rats submitted to the modified protocol showed a significant increase in survival rate, during the 3 months of the experiment (P < 0.02).


Sujets)
Animaux , Mâle , Rats , Artère carotide commune/anatomopathologie , Sténose carotidienne/physiopathologie , Troubles de la cognition/physiopathologie , Hippocampe/anatomopathologie , Hypoxie-ischémie du cerveau/physiopathologie , Cortex visuel/anatomopathologie , Sténose carotidienne/anatomopathologie , Troubles de la cognition/anatomopathologie , Modèles animaux de maladie humaine , Hypoxie-ischémie du cerveau/anatomopathologie , Apprentissage du labyrinthe , Rat Wistar , Taux de survie
2.
Rev. Assoc. Med. Bras. (1992) ; 46(4): 331-334, out.-dez. 2000. tab
Article Dans Portugais | LILACS | ID: lil-277316

Résumé

Nódulos de tireóide säo uma condiçäo clínica comum e em seu diagnóstico diferencial inclui-se o câncer de tireóide. Como o câncer de tireóide é raro, é importante conhecer a prevalência de nódulos de tireóide em grupos fortemente pre-dispostos para dimensionar seu impacto e adequar estratégias diagnósticas. OBJETIVOS: O objetivo deste estudo foi verificar a prevalência de nódulos de tireóide diagnosticados por ecografia em mulheres na maturidade. MÉTODOS: Entre agosto de 1996 e dezembro de 1997 foram avaliadas, de forma consecutiva, pacientes do sexo feminino com idade de 40 anos ou mais que realizavam ecografia no Serviço de Radiologia do HCPA...


Sujets)
Humains , Mâle , Femelle , Adulte , Adulte d'âge moyen , Tumeurs de la thyroïde , Nodule thyroïdien , Facteurs âges , Brésil/épidémiologie , Tumeurs de la thyroïde/épidémiologie , Nodule thyroïdien/épidémiologie
SÉLECTION CITATIONS
Détails de la recherche