Synthesis and anti-histaminic activity of some novel pyrimidines

Novel Pyrimidines were prepared by the condensation of Chalcones of 4 -piperazine acetophenone with guanidine HC1. The structures of the synthesized compounds RP 1-5 were assigned on the basis of Elemental analysis, IR, [1]H NMR and Mass spectroscopy. These compounds were also screened for antihistaminic activity. The recorded% of histamine inhibition showed significant antihistaminic activity when compared to the reference antihistaminic drug mepiramine