effect of indomethacin therapy on reducing the amniotic fluid index [AFI] in moderate to severe Polyhydramnios

Severe and intermediate polyhydramnios may cause various maternal and fetal complications. Indometacin therapy in moderate to severe polyhydramnios is recommended in some studies but, there no such study has been done in Iran. This study was done in order to investigate the effect of indomethacin in decreasing AFI and on enhancing duration of pregnancy. This randomized clinical trial was carried out in the year 2006 at Hamadan Fatemieh Hospital on 40 women who were 22 to 30 weeks pregnant, suffering from moderate to sever polyhydramnios [diagnosed by sonographic examination]. Patients divided randomly into two groups. Twenty patients [case group] were treated with 1/5mg/kg/day of indomethacin for two weeks and the control group were just observed and hospitalized only in case of respiratory distress or abdominal pain occurrence. patients in the case group were assessed for drug complications, then after intervention to evaluate the AFI, they were checked by sonography in the second and forth week. Both groups followed up to delivery time and neonates examined for PDA. Individual data, pregnancy duration, Apgar score, and complications were collected in the questionnaire and analyzed by SPSS software, using the descriptive statistics, frequency distribution tables and statistical tests. Statistical significance was p < 0.05. The mean duration of pregnancy in case and control group was 38 +/- 1.33 and 34 +/- 2.93 weeks respectively, with the statistically significant difference [p = 0.0001]. After 4 weeks of treatment, AFI decreased from 24.2 +/- 3.54 cm to 17.15 +/- 2.36 cm. The neonates' APGAR scores were much higher for case group in comparison with controls. Indomethacin had no maternal or fetal complications. This study showed that, the success rate in case group was 100%. The mean duration of pregnancy was longer in case group, AFI decreased and neonates' APGAR was better than the control group

The outcome of pregnancy rate after the embryo donation in natural cycle at Hamadan Infertility Center

Today, the donation of embryos, produced in vitro, is a common way to help the infertile cases who cannot produce embryo themselves by any of assisted reproductive procedures. The quality of endometrium and the time of embryo transfer are the most important factors in achieveing high pregnancy rate in these cases. The aim of this study was the assessment of pregnancy rate after embryo donation in natural cycle. This descriptive study was carried out in the year 2005 at Hamadan Infetility Center on 24 couples. A total of 24 couples went through the treatment cycles with embryos donated by 17 couples. Embryo donation was done on days of 14-17 of natural cycle and 2-3 days after the progesterone administration to the recipients. A pregnancy test was performed 2 weeks after ET, and positive results were confirmed by sonographic evaluation of the embryo. Individual, hormone administration results and embryo donation data were collected in a questionnaire, analyzed by descriptive statistics and frequency distribution tables. The mean age of the recipient and donor women were 32.2 and 26.2 years respectively.An average of 2.3 embryos were transferred on each occasion. The clinical pregnancy rate in the recipients was 30% [8.24] per embryo transfer. Transfer of donated embryos in natural cycle, results in a high pregnancy rate and is an easy, acceptable and cost-effective way of treatment for infertility