Résumé
Objective To investigate the prevalence and relationship between high risk human papillomavirus(HR-HPV)and cervical intraepithelial neoplasia(CIN)in married women from Beijing.Methods From March 2007 to September 2008,a total of 6185 married women were sampled,covering 137 communities in 12 districts.The samples were screened by high-risk HPV DNA test(HC2)and cytological test.For those participants with cytological test results≥ASCUS,pathological tests were performed.An interview was also carried out with the same questionnaire.Results from the tests were inputted into the database twice using EpiData 3.0,reviewed,analyzed,using SPSS 15.0.Results(1)The prevalence rates of HR-HPV and CIN were 9.9% and 6.0%,respectively for the age group 25 to 54.(2)The peak age groups for HR-HPV and CIN prevalence rates were 30 to 34 years old.(3)The prevalence rates of positive cytology(40.3%)and CIN (30.4%)in HR-HPV positive female population were significantly higher than that in HR-HPV negative group.(4)Data from unconditional logistic regression analysis showed that,when comparing with the normal subjects,the risk odds ratios of HR-HPV with low grade CIN and cervical cancer/high grade CIN were 8.385 and 97.416 and the attributable risk proportions with these groups were 88.1% and 99.0%,respectively.Conclusion HR-HPV infection seemed to be the main risk factor for CIN.Married women,from age group 30-34,were under the high risk group in both HR-HPV infection and CIN incidence.
Résumé
Objective To determine the prevalence and determinants of the most commonly seen lower reproductive tract infections among women aged 25-54 years in Beijing.Methods The study population consisted of 6339 women aged 25-54 years in 137 communities of Beijing.Focus of this study was to understand the prevalence of the following diseases as:bacterial vaginosis,trichomoniasis and vulvovaginal candidiasis.In addition to their prevalence rates,a generalized equation for estimation was used to analyze those infection-associated factors.Results The overall infection prevalence in the lower reproductive tract was 11.4%,including bacterial vaginitis as 8.7%,trichomonads as 1.0% and vulvovaginal candidiasis as 1.7%.Factors which were found to be significantly associated with lower reproductive tract infections in women were age,profession,family income,number of sex partners and frequency of condom use during sexual contacts.In patients with bacterial vaginitis,both prevalence rates of cervical intraepithelial neoplasia and infection of human papillomavirus were high.Conclusion The prevalence of the most commonly seen lower reproductive tract infections among women aged 25-54 years in Beijing was lower than other areas in China.Lower reproductive tract infections seemed to be related to 30-49 years of age,nongovernmental employee,poverty,higher number of sex partners and not using condoms during sexual contacts.