Résumé
To compare the efficacy and safety of cervical ripening at term by vaginal Misoprostol and Dinoprostone. We performed a prospective randomized study on cervical ripening with misoprostol and dinoprostone in the third trimester of pregnancy. 300 patients have been divided into two groups: one consisted by 150 patients who received Misoprostol [Cytotec registered] and the second consisted by 150 patients who received Dinoprostone [Prpidil registered]. Analysis of our results allowed to reveal: a significant decrease in the time of entry into work for the Misoprostol group [9.08 hours versus 12.51 hours, p = 0.007], a significant reduction delivery time [14.48 hours versus 19.30 hours, p = 0.001]. Moreover, the birth rate in the first 24 hours after the first dose was significantly higher in the Misoprostol group [86.7% versus 72.7%, p = 0.003]. The use of oxytocin was significantly reduced with Misoprostol [44% versus 58.7%, p = 0.01]. The mode of delivery was not influenced by membership in one or other of the two groups. Misoprostol seems an interesting molecule for cervical ripening and labor induction