Effect of eccentric training on mitochondrial function and oxidative stress in the skeletal muscle of rats

The objective of the present study was to investigate the effects of eccentric training on the activity of mitochondrial respiratory chain enzymes, oxidative stress, muscle damage, and inflammation of skeletal muscle. Eighteen male mice (CF1) weighing 30-35 g were randomly divided into 3 groups (N = 6): untrained, trained eccentric running (16°; TER), and trained running (0°) (TR), and were submitted to an 8-week training program. TER increased muscle oxidative capacity (succinate dehydrogenase and complexes I and II) in a manner similar to TR, and TER did not decrease oxidative damage (xylenol and creatine phosphate) but increased antioxidant enzyme activity (superoxide dismutase and catalase) similar to TR. Muscle damage (creatine kinase) and inflammation (myeloperoxidase) were not reduced by TER. In conclusion, we suggest that TER improves mitochondrial function but does not reduce oxidative stress, muscle damage, or inflammation induced by eccentric contractions.

O ideal, o rito e o mito na constituicao atual da terapia ocupacional / The ideal, the rite and the myth in atual constitution of occupational therapy

O tema e desenvolvido a partir do modelo trigeracional da familia. Ele se compoe do herdado dos avos, constituindo o ideal, do assumido pelos pais atraves do rito e da proposta dos filhos, no mito. Nosso trabalho e resgatar o ideal e o rito atraves do mito. Para isso e preciso abrir o mito, desmistifica-lo, buscar seu valor original. Procedendo a verificacao da adequacao e significado desse valor para o desenvolvimento atual da profissao, transformamos o mito em conhecimento.