Outcomes of Injection Laryngoplasty for Deep Interarytenoid Groove

Abstract Introduction Deep interarytenoid groove (DIG) may cause swallowing dysfunction in children; however, the management of DIG has not been established. Objective We evaluated the subjective and objective outcomes of interarytenoid augmentation with injection in children with DIG. Methods Consecutive children under 18 years of age who underwent injection laryngoplasty for DIG were reviewed. Data pertaining to demographics, past medical history, past surgical history, and results of pre and postoperative video fluoroscopic swallow study (VFSS) were obtained. The primary outcome measure was the presence of thin liquid aspiration or penetration on postoperative VFSS. The secondary outcome measure was caregiver-reported improvement of symptoms. Results Twenty-seven patients had VFSS before and after interarytenoid augmentation with injection (IA). Twenty (70%) had thin liquid penetration and 12 (44%) had thin liquid aspiration before the IA. Thin liquid aspiration resolved in 9 children (45%) and persisted in 11 (55%). Of the 12 children who had thin liquid aspiration prior to IA, 6 (50%) had resolution of thin liquid aspiration after IA. Conclusions Injection laryngoplasty is a safe tool to improve swallowing function in children with DIG. Further studies are needed to assess the long-term outcomes of IA and identify predictors of successful IA in children with DIG.

Physiological Assessment of Temperature Stress Tolerance in Selectively Fertilzed Coconut Hybrids

In vitro pollen germination study is one of the important technologies for understanding the functions of pollens as well as in many areas of pollen biotechnology particularly in pollen selection. Ability to separate germinated and non-germinated pollen offers selective treatments and can be used for identifying stress tolerant and sensitive alleles carried by their pollen grains. The present study was carried out in Kerasree and Keraganga selectively fertilized (S.F) coconut hybrids produced through pollen selection. Pollens were subjected to germination in specific media maintained at different levels of water stress induced by PEG 6000 and the critical water potential for pollen germination was identified. The water stress tolerant pollen grains at critical level were selected and used for fertilization. Evaluation of temperature stress tolerance of these two selectively fertilized hybrids along with their normal hybrids and west coast tall (WCT) was carried out by assessing their critical temperature stress for pollen germination. Both Kerasree selectively fertilized and Keraganga selectively fertilized hybrids recorded highest critical temperature of 420C for pollen germination with germination percentage of 20.17 and 22.77 respectively compared to their normal hybrids (380C) and WCT (400C).

Molecular Frameworks of Nitrogen Response in Plants: A Review

Nitrogen is a crucial element for all living organisms especially plants which rely on substantial nitrogen quantities to sustain their growth and productivity. Crop production is greatly influenced by nitrogen consumption efficiency and a significant amount of nitrogen fertilizers is used to increase yield. Approximately half of N fertilizers are not utilized by the crops and are lost to the environment by polluting water sources or by releasing pollutants into the atmosphere. From the rhizosphere, plants absorb nitrogen in the form of nitrate (NO3-), ammonium (NH4+), or organic nitrogen (amino acids and urea). Plants exhibit an array of sensing and adaptive mechanisms to respond to the diverse nitrogen nutrition conditions which include morphological and physiological responses. Two primary systems govern nitrogen uptake in plants: the High-affinity transport system (HATS) and the Low-affinity transport system (LATS). Nitrate transporters fall into two categories, Nitrate Transporter 1 (NRT1) and Nitrate Transporter 2 (NRT2) transporters, Chloride Channel Family (CLC) transporters and Slow Anion Associated Channel Homologs (SLAC/SLAHs). The ammonium transporter family includes Ammonium Transporter 1 (AMT1) and Ammonium Transporter 2 (AMT2) transporters. The uptake of organic nitrogen is facilitated through amino acid and urea uptake and transport systems. In fluctuating environmental conditions, plants employ nitrogen response mechanisms to fine-tune homeostasis. A comprehensive understanding of these regulatory mechanisms holds the potential to yield valuable insights for the development of crops with enhanced nitrogen use efficiency.

Assessment of Nutrient Status in the Cassava Growing Tracts of Southern Laterites (Agro Ecological Unit 8), Kerala, India

As part of the study, a survey was conducted to identify the soil fertility constraints of cassava growing tracts of AEU 8, Thiruvananthapuram, which is one of the major cassava growing regions of the State of Kerala in peninsular India. The method of sampling of the survey was random sampling wherein a random sample of size one was taken from each of 50 ha cassava area. Panchayat wise soil samples were collected (77 samples) by geo referenced soil sampling method from major cassava growing areas of the unit. The samples are analyzed for the soil fertility parameters following standard analytical procedures. Results indicated that the soil was very strongly acidic to strongly acidic, normal electrical conductivity, medium organic carbon, medium nitrogen and potassium, high phosphorus, sufficient calcium, sulphur, zinc and copper, deficient magnesium and boron.

Neurological and neuropsychological sequelae of Zika virus infection in children in León, Nicaragua / Secuelas neurológicas y neuropsicológicas de la infección por el virus del Zika en niños y niñas en León, Nicaragua / Sequelas neurológicas e neuropsicológicas da infecção pelo vírus zika em crianças em León, Nicarágua

ABSTRACT Objectives. To describe the presence and persistence of neurological and neuropsychological sequelae among children with acquired Zika virus infection and assess whether those sequelae were more common in children infected with Zika virus compared to uninfected children. Methods. We conducted a prospective cohort study of children with and without Zika virus infection in León, Nicaragua, using a standard clinical assessment tool and questionnaire to collect data on symptoms at three visits, about 6 months apart, and a battery of standardized instruments to evaluate neurocognitive function, behavior, depression, and anxiety at the last two visits. Results. Sixty-two children were enrolled, with no significant differences in demographics by infection group. Children infected with Zika virus had a range of neurological symptoms, some of which persisted for 6 to 12 months; however, no consistent pattern of symptoms was observed. At baseline a small percentage of children infected with Zika virus had an abnormal finger-to-nose test (13%), cold touch response (13%), and vibration response (15%) versus 0% in the uninfected group. Neurocognitive deficits and behavioral problems were common in both groups, with no significant differences between the groups. Children infected with Zika virus had lower cognitive efficiency scores at the 6-month visit. Anxiety and depression were infrequent in both groups. Conclusions. Larger studies are needed to definitively investigate the relationship between Zika virus infection and neurological symptoms and neurocognitive problems, with adjustment for factors affecting cognition and behavior, including mood and sleep disorders, home learning environment, history of neuroinvasive infections, and detailed family history of neuropsychological problems.

RESUMEN Objetivos. Describir la presencia y persistencia de secuelas neurológicas y neuropsicológicas en pacientes pediátricos que contrajeron la infección por el virus del Zika y evaluar si dichas secuelas fueron más comunes en los infectados con el virus del Zika en comparación con los no infectados. Métodos. Se realizó un estudio de cohorte prospectivo en pacientes pediátricos con y sin infección por el virus del Zika en León (Nicaragua), con una herramienta de evaluación clínica estándar y un cuestionario para recopilar datos sobre los síntomas en tres visitas, con aproximadamente seis meses de diferencia, y un conjunto de instrumentos estandarizados para evaluar la función neurocognitiva, el comportamiento, la depresión y la ansiedad en las últimas dos visitas. Resultados. Participaron 62 niños y niñas sin diferencias significativas en la demografía por grupo de infección. Los participantes infectados con el virus del Zika mostraron una variedad de síntomas neurológicos, algunos de los cuales persistieron entre 6 y 12 meses; no obstante, no se observó un patrón sistemático en los síntomas. Al inicio del estudio, un pequeño porcentaje de participantes infectados con el virus del Zika mostró resultados anormales a las pruebas dedo-nariz (13%), respuesta al tacto (frío) (13%) y respuesta a la vibración (15%), frente a un 0% en el grupo no infectado. Los déficits neurocognitivos y los problemas de comportamiento fueron comunes en ambos grupos, sin diferencias significativas entre los grupos. Los participantes infectados con el virus del Zika mostraron puntuaciones de eficiencia cognitiva más bajas en la visita a los 6 meses. La ansiedad y la depresión fueron poco frecuentes en ambos grupos. Conclusiones. Son necesarios estudios más amplios para investigar definitivamente la relación entre la infección por el virus del Zika y los síntomas neurológicos y los problemas neurocognitivos, haciendo ajustes para los factores relacionados con la cognición y el comportamiento, incluidos los trastornos del estado de ánimo y el sueño, el entorno de aprendizaje en el hogar, los antecedentes de infecciones neuroinvasivas y los antecedentes familiares detallados de problemas neuropsicológicos.

RESUMO Objetivos. Descrever a presença e a persistência de sequelas neurológicas e neuropsicológicas em crianças com infecção pelo vírus zika e avaliar se essas sequelas foram mais comuns em crianças infectadas pelo vírus zika em comparação com crianças não infectadas. Métodos. Realizamos um estudo de coorte prospectivo em crianças com e sem infecção pelo vírus zika em León, Nicarágua, usando uma ferramenta de avaliação clínica padrão e um questionário para coletar dados de sintomas em três consultas, com cerca de 6 meses de intervalo, além de um conjunto de ferramentas padronizadas para avaliar função neurocognitiva, comportamento, depressão e ansiedade nas duas últimas consultas. Resultados. Foram incluídas 62 crianças, sem diferenças significativas nas características demográficas por grupo de infecção. As crianças infectadas pelo vírus zika tinham uma gama de sintomas neurológicos, alguns dos quais persistiram por 6 a 12 meses. Entretanto, não se observou nenhum padrão consistente de sintomas. No início do estudo, uma pequena porcentagem de crianças infectadas com o vírus zika apresentou resultado anormal na prova índex-nariz (13%), resposta ao toque frio (13%) e sensibilidade vibratória (15%), em comparação a 0% no grupo não infectado. Déficits neurocognitivos e problemas comportamentais foram frequentes em ambos os grupos, mas sem diferenças significativas entre eles. As crianças infectadas com o vírus zika tiveram resultados mais baixos de eficiência cognitiva na consulta de 6 meses. Ansiedade e depressão não foram observadas com frequência em ambos os grupos. Conclusões. São necessários estudos mais amplos para investigar a relação exata entre a infecção pelo vírus zika e sintomas neurológicos e problemas neurocognitivos, com ajuste para fatores que afetam a cognição e o comportamento, incluindo distúrbios do humor e do sono, ambiente de aprendizagem em casa, história de infecções neuroinvasivas e história familiar detalhada de problemas neuropsicológicos.

Timed Up And Go Performance In Older People With Diabetes Mellitus: Associations With Sensorimotor Function, Balance, Cognition, And Falls

Background: The Timed up and Go Test (TUG) is often used as a mobility measure in older people. However, it is unclear whether the TUG is useful for identifying fall risk in people with diabetes mellitus (DM) and which physical and cognitive/psychological factors influence the performance of this test. Objectives: To investigate whether slow TUG times (standard test and when performed with a secondary cognitive task (c-TUG)) are a risk factor for falls in older people with DM and to determine the relative contributions of a range of sensorimotor, balance and cognitive/psychological factors to TUG performance in this population. Methods: Community-dwelling people (n=103, mean age 61.57, SD=6.3) underwent the TUG and c-TUG tests as well as quantitative tests of vision, peripheral sensation, strength, reaction time, balance, cognition, and fear of falling. Participants were then followed up for falls for six months. Results: Negative binomial regression analyses revealed that each 1s increase in TUG and c-TUG times increased the risk of falling by 29% and 13%, respectively. Multiple regression analyses identified vibration sense (p<0.001), knee extension strength (p=0.001, r²=0.430), edge contrast sensitivity (p=0.002), neuropathy examination score (p=0.001, r²=0.498) and controlled leaning balance (p=0.033) as significant and independent explanatory predictors of TUG performance. The regression model for c-TUG was similar, vibration sense (p=0.042), knee extension strength (p=0.009, r²=0.256), neuropathy examination score (p=0.156, r²=0.272) and sway path-floor (p=0.042) except that the MOCA cognitive assessment (p=0.015) was included instead of edge contrast sensitivity. The combined explanatory variable models explained 43% and 26% of the variance in TUG and c-TUG times, respectively. Conclusions: Slow TUG and c-TUG times significantly increased the risk of falls in community-dwelling older people with DM. Poor TUG and c-TUG performances were related independently to decreased vibration sense, lower limb weakness, and poor balance, with the c-TUG additionally influenced by cognitive function.

Hepatitis D Virus: An Overview for Dentists

Hepatitis D is considered to be the most severe form of viral hepatitis. This virus requires hepatitis B for its life cycle and it is estimated that at least 5% of hepatitis B virus infected patients are also infected with hepatitis D, counting for 15 million infections worldwide most optimistically. Hepatitis D has a similar transmission pattern to hepatitis B and hepatitis C viruses. However, there is less information about the virus of hepatitis D than aboutthe other agents of viral hepatitis. In particular, there is total lack of information on hepatitis D in the setting of dental diseases and management. To our knowledge, there are only few reports on hepatitis D of dental health care workers (DHCW), the association of hepatitis D with oral conditions and on the role of oral fluid in transmission of hepatitis D. The present report reviews current knowledge of hepatitis D for dentists and dental personnel. Therefore, epidemiology, transmission modes, sign and symptoms, diagnostic methods and treatment options of hepatitis D are discussed under relevant subheadings

Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell line

BACKGROUND: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in the understanding of molecular mechanisms underlying this drug-resistance phenomenon. The aim of this study was to characterize cellular and molecular changes of induced CBDCA-resistant ovarian cancer cell line A2780. METHODS: The cell selection strategy used in this study was a dose-per-pulse method using a concentration of 100 µM for 2 h. Once 20 cycles of exposure to the drug were completed, the cell cultures showed a resistant phenotype. Then, the ovarian cancer cell line A2780 was grown with 100 µM of CBDCA (CBDCA-resistant cells) or without CBDCA (parental cells). After, a drug sensitivity assay, morphological analyses, cell death assays and a RNA-seq analysis were performed in CBDCA-resistant A2780 cells. RESULTS: Microscopy on both parental and CBDCA-resistant A2780 cells showed similar characteristics in morphology and F-actin distribution within cells. In cell-death assays, parental A2780 cells showed a significant increase in phosphatidylserine translocation and caspase-3/7 cleavage compared to CBDCA-resistant A2780 cells (P < 0.05 and P < 0.005, respectively). Cell viability in parental A2780 cells was significantly decreased compared to CBDCA-resistant A2780 cells (P < 0.0005). The RNA-seq analysis showed 156 differentially expressed genes (DEGs) associated mainly to molecular functions. CONCLUSION: CBDCA-resistant A2780 ovarian cancer cells is a reliable model of CBDCA resistance that shows several DEGs involved in molecular functions such as transmembrane activity, protein binding to cell surface receptor and catalytic activity. Also, we found that the Wnt/3-catenin and integrin signaling pathway are the main metabolic pathway dysregulated in CBDCA-resistant A2780 cells.

Antidiabetic effects of galactomannans from Adenanthera pavonina L. in streptozotocin-induced diabetic mice

Objective:To evaluate the antidiabetic effect of galactomannans extracted from Adenanthera pavonina's L. seeds (GAP) in streptozotocin (STZ) induced diabetic mice.Methods:The preliminary galactomannan yield from Adenanthera pavonina L. plant and extraction products composition were evaluated. Various chemical characterization methods like thin layer chromatography, Fourier transform infrared spectroscopy,Results:The isolated and extracted galactomannan from Adenanthera pavonina was confirmed by various chemical characterization methods. GAP exhibited a 1.46:1 mannose: galactose ratio, and high molar weight. Both GAP enriched food decreased glycaemia, total cholesterol and triacylglycerol. GAP didn't interfere on food intakes or body weight, although it increased water intake. Furthermore, the relative liver weight indicated toxic galactomannan effects on the histopathological changes of the pancreas in STZ induced diabetes.Conclusions:It is concluded that GAP is a natural product that contains potent galactomannan and is useful in preventing and treating diabetes.

Antihyperglycemic effect of Passiflora glandulosa cav. fruit rinds flour in streptozotocin-induced diabetic mice

Objective:To investigate the effect of administration of Passiflora glandulosa (P. glandulosa) fruit rinds flour on streptozotocin (STZ)-induced diabetic mice.Methods:The preliminary phytochemical screening and parameters such as centesimal composition and brine shrimp toxicity were evaluated. For in vivo study Swiss female mice were divided into four groups: NC-normal control; DC-diabetic control animals receiving saline; MET-diabetic animals receiving metformin (200 mg/kg); PFRF-diabetic animals receiving P. glandulosa fruit rinds flour (200 mg/kg). All of them were treated for 28 d. STZ was used in a single dose of 120 mg/kg to establish diabetic models. Body weight, water and food intake, fasting blood glucose were measured. Histopathological analysis of pancreas and liver were performed to evaluate STZ-induced tissue injuries.Results:Phytochemical screening showed the presence of flavanones and triterpenoids. The P. glandulosa fruit rinds flour was non-toxic by the brine shrimp test. The fruit rinds flour also reduced the loss of body weight and significantly decreased food intake in the diabetic mice. Additionally, a significant reduction in blood glucose was observed for 15 d and this was maintained on 21 d and 28 d when compared with diabetic mice. Furthermore, the P. glandulosa fruit rinds flour has a favourable effect on the histopathological changes of the pancreas in STZ induced diabetes.Conclusions:It is concluded that P. glandulosa fruit rinds flour is a natural product that contains potent antioxidant compounds and presents good prospects for the improvement of diabetic mellitus by reducing serum glucose levels.

Burden of laboratory-confirmed campylobacter infections in Guatemala 2008-2012: results from a facility-based surveillance system

Campylobacteriosis is one of the leading causes of gastroenteritis worldwide. This study describes the epidemiology of laboratory-confirmed Campylobacter diarrheal infections in two facility-based surveillance sites in Guatemala. Clinical, epidemiologic, and laboratory data were collected on patients presenting with acute diarrhea from select healthcare facilities in the departments of Santa Rosa and Quetzaltenango, Guatemala, from January 2008 through August 2012. Stool specimens were cultured for Campylobacter and antimicrobial susceptibility testing was performed on a subset of isolates. Multidrug resistance [MDR] was defined as resistance to >/= 3 antimicrobial classes. Campylobacter was isolated from 306 [6.0%] of 5137 stool specimens collected. For children <5 years of age, annual incidence was as high as 1288.8 per 100,000 children in Santa Rosa and 185.5 per 100,000 children in Quetzaltenango. Among 224 ambulatory care patients with Campylobacter, 169 [75.5%] received metronidazole or trimethoprim-sulfamethoxazole, and 152 [66.7%] received or were prescribed oral rehydration therapy. Antimicrobial susceptibilities were tested in 96 isolates; 57 [59.4%] were resistant to ciprofloxacin and 12 [12.5%] were MDR. Campylobacter was a major cause of diarrhea in children in two departments in Guatemala; antimicrobial resistance was high, and treatment regimens in the ambulatory setting which included metronidazole and trimethoprim-sulfamethoxazole and lacked oral rehydration were sub-optimal

The role of exercise for fall prevention in older age / El papel del ejercicio para la prevención de caídas en la vejez / O papel do exercício na prevenção de quedas entre idosos

Falls are a common, costly and preventable consequence of sensorimotor impairments that increase in prevalence with advancing age. A fall occurs when the physical ability of the individual is unable to match the immediate demands of the environment and/or of the activity being undertaken. Targeted exercise aimed at improving the physical ability of the individual, such as balance and strength training, is crucial for promoting functional independence and mobility and reducing the risk of falling in older age. Exercise programs that provide a high challenge to balance, have a high dose, include progression of intensity over time and are ongoing are most effective for preventing falls. This paper provides guidance to health professionals involved with the prescription of physical activity and exercise to older people regarding the safe and effective provision of programs aimed at improving strength and balance and preventing falls in older age.

As quedas são uma consequência comum, caras e evitáveis decorrentes das deficiências sensoriomotoras que aumentam em incidência com o avanço da idade. A queda ocorre quando a capacidade física do indivíduo não responde às demandas imediatas do ambiente e/ou da atividade realizada. Exercícios específicos destinados a melhorar a capacidade física do indivíduo, tais como equilíbrio e treinamento de força, são fundamentais para promover a independência funcional e mobilidade, e reduzir o risco de cair em idade mais avançada. Programas de exercício que oferecem um desafio maior ao equilíbrio, oferecidos com frequência, que incluem a progressão da intensidade ao longo do tempo e sem interrupção são mais eficazes para a prevenção de quedas. Este documento fornece orientações para os profissionais de saúde envolvidos com a prescrição de atividade física e exercício físico para pessoas idosas em relação à prestação segura e eficaz de programas destinados a melhorar a força e equilíbrio e prevenção de quedas na velhice.

Las caídas son una consecuencia común, costosa y prevenibles de discapacidades sensoriomotoras resultantes de ese aumento de la incidencia con la edad. La caída se produce cuando la capacidad física del individuo no responde a las exigencias inmediatas del medio ambiente y/o de la actividad desarrollada. Los ejercicios específicos diseñados para mejorar la capacidad física del individuo, tales como el equilibrio y entrenamiento de la fuerza, es crucial para promover la independencia funcional y la movilidad, y reducir el riesgo de caer en la vejez. Los programas de ejercicios que ofrecen un mayor desafío al equilibrio, se ofrece con frecuencia, incluyendo la progresión de la intensidad con el tiempo y sin interrupción son los más efectivos para la prevención de caídas. Este documento proporciona una guía para los profesionales de la salud implicados en la prescripción de la actividad física y el ejercicio para las personas ancianas con respecto a la prestación segura y eficaz de los programas destinados a mejorar la fuerza y el equilibrio y la prevención de caídas en la vejez.

Effect of exercise training on functional capacity & quality of life in head & neck cancer patients receiving chemoradiotherapy.

Background & objectives: Patients with head and neck cancer (HNC) undergoing chemoradiotherapy (CRT) suffer from fatigue causing a decrease in functional capacity and quality of life (QoL). Limited research in the field of exercise training among these patients demanded the need for this study to assess the effects of exercise training on functional capacity and quality of life. Methods: A randomized controlled trial was conducted on 48 patients with HNC undergoing CRT. The exercise group received an individually tailored, supervised, exercise programme for six weeks, while the control group did not receive any form of exercise. Functional capacity and QoL were assessed at baseline and at the end of the intervention using the six minute walk distance (6MWD) and medical outcomes survey short form 36 (SF 36). Results: The mean age of patients was 52 yr with 42 males. After six weeks, the 6MWD improved by 42 metres (P<0.05) in the exercise group while the control group showed a decrease by 96 metres (P<0.001). There was an improvement on the mental component score (MCS) of SF36 for the exercise group (4.8; P<0.05) and the physical component score (PCS) remained almost the same, while a decrease in PCS and MCS was seen in the control group (-5.9; P=0.064 and -17.3; P<0.05). When 6MWD and SF36 were compared between the groups, there was a statistically significant difference (P<0.001) seen after six weeks. Interpretation & conclusions: Our results showed that the functional capacity and QoL decreased among those not receiving a supervised exercise program, while exercise training improved functional capacity and QoL in HNC patients undergoing CRT.

Pancreatic Fluid Collection Drainage by Endoscopic Ultrasound: An Update

Endoscopic management of symptomatic pancreatic fluid collections (PFCs) is now considered to be first line therapy. Expanded use of endoscopic ultrasound (EUS) techniques has resulted in increased applicability, safety, and efficacy of endoscopic transluminal PFC drainage. Steps include EUS-guided trangastric or transduodenal fistula creation into the PFC followed by stent placement or nasocystic drain deployment in order to decompress the collection. With the remarkable improvement in the available accessories and stents and development of exchange free access device; EUS drainage techniques have become simpler and less time consuming. The use of self-expandable metal stents with modifications to drain PFC has helped in overcoming some previously encountered challenges. PFCs considered suitable for endoscopic drainage include collection present for greater than 4 weeks, possessing a well-formed wall, position accessible endoscopically and located within 1 cm of the duodenal or gastric walls. Indications for EUS-guided drainage have been increasing which include unusual location of the collection, small window of entry, nonbulging collections, coagulopathy, intervening varices, failed conventional transmural drainage, indeterminate adherence of PFC to the luminal wall or suspicion of malignancy. In this article, we present a review of literature to date and discuss the recent developments in EUS-guided PFC drainage.

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

The global obesity epidemic has resulted in significant morbidity and mortality. However, the medical treatment of obesity is limited. Gastric bypass is an effective surgical treatment but carries significant perioperative risks. The gut hormones, peptide tyrosine tyrosine (PYY) and glucagon-like peptide 1 (GLP-1), are elevated following gastric bypass and have been shown to reduce food intake. They may provide new therapeutic targets. This review article provides an overview of the central control of food intake and the role of PYY and GLP-1 in appetite control. Key translational animal and human studies are reviewed.

Cisto linfoepitelial em língua: relato de caso / Limphoepithelial cyst on tongue: a case report

O cisto linfoepitelial oral (CLEO) é uma lesão incomum da boca, que se desenvolve do tecido linfoide oral. Clinicamente apresenta-se como uma lesão nodular, que raramente apresenta mais de 1,5 cm em seu maior diâmetro. Possui coloração branco-amarelada, superfície regular, é mole à palpação e assintomático na maioria dos casos, embora possa apresentar tumefação e drenagem, se associado a episódios de trauma. A localização mais freqüente dessa lesão na cavidade oral é o assoalho de boca, seguido da superfície ventral e borda lateral de língua. O CLEO é encontrado em pacientes de várias faixas etárias, porém é mais comum em adultos jovens. Neste artigo, relatamos um caso de CLEO e revisamos a literatura sobre o tema.

The oral lymphoepithelial cyst (CLEO) is an uncommon injury in the oral cavity that develops oral lymphoid tissue. Clinically, it presents as a nodular lesion that rarely has more than 1.5 cm in its largest diameter. It has a whitish-yellow, soft on palpation and asymptomatic in most cases, and although there may be swelling and drainage are associated with episodes of trauma. The most frequent location of this lesion in the oral cavity is the mouth's floor followed by the ventral surface and lateral border of the tongue. The CLEO can be foundbe found in patients of diff erent ages but it is most common in young adults. In this paper, we report a case of oral lymphoepithelial cyst later, discussing the current literature regarding this lesion.

Ramadan and its effect on fuel selection during exercise and following exercise training

Fasting induces short-term physiological adaptations which spare the body's remaining carbohydrate stores and mobilize lipid stores to provide a substitute fuel for many tissues and organs, especially skeletal muscle. Rodent studies show that regular occurrence of fasting then refeeding, stimulates adaptations in muscle which make the animal better placed to withstand a further period of fasting by possessing a better ability to oxidise lipid. This review explores the research describing these adaptations, with an emphasis on Ramadan, a human model of repeated fasting/refeeding. Separately, a single bout of endurance exercise places similar metabolic stress on the body as fasting since the exercising muscle must reduce its use of carbohydrate and utilize lipid more readily as exercise progresses. Not surprisingly therefore, adaptations in muscle to repeated bouts of endurance exercise [endurance training] are similar to those seen with repeated fasting/refeeding. Superimposing the stressors of repeated fasting/refeeding and exercise training, and subsequent adaptations to the muscle and exercise response, are examined by describing the published research which has investigated the situation where athletes continue their training whilst participating in Ramadan

Effects of Ramadan fasting on biochemical and anthropometric parameters in physically active men

The aim of this study was to assess the effects of Ramadan fasting on several biochemical and anthropometric parameters in physically active men by comparing fasters and nonfasters before, during, and after Ramadan. Eighteen physically active men [10 fasters and 8 nonfasters] participated in this study. Subjects visited the laboratory for a total of four sessions on the following occasions: three days before Ramadan [Bef-R], the 15th day of Ramadan [Mid-R], the 29th day of Ramadan [End-R], and 21 days after Ramadan [Post-R]. During each session, subjects underwent anthropometric measurements, completed a dietary questionnaire and provided a fasting blood sample. Body weight and body fat percentage decreased in fasters by 1.9% [P<0.001] and 6.2% [P=0.003], respectively, but increased in nonfasters by 2.2% [P<0.001] and 10.2% [P=0.001], respectively, from Bef-R to End-R. Fasters' hematocrit and hemoglobin increased by 5.3% [P<0.001] and 6.3% [P=0.01], respectively, from Bef-R to End-R, while neither of these parameters changed in nonfasters. Fasters experienced an increase in the following parameters from Bef-R to End-R: urea [8.7%; P<0.001], creatinine [7.5%; P<0.001], uric acid [12.7%; P<0.001], serum sodium [1.9%; P<0.001], serum chloride [2.6%; P<0.001] and high-density lipoprotein cholesterol [27.3%; P<0.001]. Of these parameters, only creatinine increased [4.4%; P=0.01] in nonfasters. We conclude that Ramadan fasting lowers body weight and body fat percentage and can elevate high-density lipoprotein cholesterol in physically active men. However, practicing aerobic exercise during a hot and humid Ramadan month can induce a state of dehydration marked by an increase in some renal function markers and serum electrolytes

Effect of Ramadan fasting on body water status markers after a rugby sevens match

To evaluate the effect of Ramadan fasting on body water status markers of rugby players at basal condition and following a simulation of rugby sevens match. Twelve recreational rugby sevens players played three matches: one day before Ramadan [before Ramadan], at the end of the first week of Ramadan [Beg-R] and at the end of Ramadan [End-R]. Before and immediately after each match, body weight was determined and blood samples were taken for the measurement of body water status markers. Total body water was measured with an impedancemeter only before matches. At rest, an increase in hematocrit [+4.4%, P=0.03], hemoglobin [+3.4%, P=0.01] and plasma osmolarity [+2.8%, P<0.001] was noticed at End-R compared to before Ramadan. Total body water measured before Ramadan did not differ significantly from that of Ramadan. After the match, values of hematocrit and plasma osmolarity increased significantly at End-R [+1.4%, P=0.02;+3.1%, P<0.001 respectively] compared to before Ramadan. Although, hemoglobin measured after matches occurring during Ramadan did not differ from those of before Ramadan. In response to matches, the change of percentage of body water status markers did not differ during each period of the investigation. The present results show that Ramadan fasting induces dehydration at basal conditions. Also, rugby sevens match played during Ramadan did not exacerbate the magnitude of responses to matches of blood and body water status markers