Pathological grading diagnosis of pancreatic neuroendocrine neoplasms / 中国实用外科杂志

The pathological grading diagnosis of pancreatic neuroendocrine neoplasms is the basis of clinical treatment and prognosis.The general principle guiding the classification of NEN has been evoluted several times.From the size of tumor,to the proliferation index as a key factor,and subsequently proposed distuishing between well-differentiated neuroendocrine tumors and poorly differentiated neuroendocrine carcinomas.Firstly,neuroendocrine tumors and neuroendocrine carcinomas were classified according to their morphology.Then,according to mitotic image and Ki67 proliferation index,the former was classified into G1,G2 and G3 grades.