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Mem. Inst. Oswaldo Cruz ; 101(3): 287-290, May 2006. tab
Article Dans Anglais | LILACS | ID: lil-431728

Résumé

Twelve extracts obtained from nine plants belonging to six different genera of Clusiaceae were analyzed against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus and Enterococcus faecalis) bacteria using the microdilution broth assay. Tovomita aff. longifolia, T. brasiliensis, Clusia columnaris, Garcinia madruno, Haploclathra paniculata, and Caraipa grandifolia extracts showed significant results against the bacteria. The organic extract obtained from the leaves of T. aff. longifolia showed minimal inhibitory concentration (MIC) = 70 µg/ml and minimal bactericidal concentration (MBC) = 90 µg/ml against E. faecalis and the organic extract made with the stem of C. columnaris showed MIC = 180 µg/ml and MBC = 270 µg/ml against P. aeruginosa. None of the antibacterial extracts showed lethal activity against brine shrimp nauplii. On the other hand, both aqueous and organic extracts obtained from the aerial organs of Vismia guianensis that were cytotoxic to brine shrimp nauplii did not show a significant antibacterial activity in the assay.


Sujets)
Animaux , Antibactériens/pharmacologie , Bactéries à Gram négatif/effets des médicaments et des substances chimiques , Bactéries à Gram positif/effets des médicaments et des substances chimiques , Clusiaceae/composition chimique , Antibactériens/toxicité , Artemia/effets des médicaments et des substances chimiques , Clusiaceae/classification , Enterococcus faecalis/effets des médicaments et des substances chimiques , Escherichia coli/effets des médicaments et des substances chimiques , Extraits de plantes/pharmacologie , Extraits de plantes/toxicité , Dose létale 50 , Tests de sensibilité microbienne , Pseudomonas aeruginosa/effets des médicaments et des substances chimiques , Staphylococcus aureus/effets des médicaments et des substances chimiques
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