Résumé
Gangliogliomas (GG) are mixed glioneuronal tumors of the central nervous system (CNS), occurring mostly in the pediatric population, with common sites being temporal lobes and less commonly in the frontal and parietal lobes. We report a case of a 7-year-old child who presented with bilateral visual defects for 6 months. Magnetic resonance imaging (MRI) of the brain revealed an intensely enhancing mass lesion with calcification in the sellar and suprasellar region involving the optic chiasm and the left optic nerve. The mass showed almost bilaterally symmetrical diffuse spread along the optic tracts posteriorly and hypothalamus, temporal lobes, thalami and the basal ganglia. The lesion was radiologically indistinguishable from chiasmatic astrocytoma or a germ cell tumor but histopathological features were of a ganglioglioma. While a few optic apparatus gangliogliomas have been reported in the literature, such widespread diffuse involvement of the entire optico-chiasmal hypothalamic pathway is unusual.
Sujets)
Antinéoplasiques/usage thérapeutique , Tumeurs du cerveau/métabolisme , Enfant , Association thérapeutique , Femelle , Gangliogliome/métabolisme , Humains , Hypothalamus/anatomopathologie , Immunohistochimie , Imagerie par résonance magnétique , Procédures de neurochirurgie , Chiasma optique/anatomopathologie , Radiochirurgie , Radiothérapie conformationnelle , Voies optiques/anatomopathologieRésumé
We report a 60 year-old-man who presented with generalized abdominal colicky pain. He had a history of left great toe dysarticulation done for amelanotic melanoma one year ago. Investigations were suggestive of metastases of melanoma to the small intestine. Exploratory laparotomy with segmental ileal resection and anastomosis was performed. Histological examination showed features of amelanotic melanoma characterized by absence of melanin pigment.