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Acta Pharmaceutica Sinica ; (12): 924-930, 2005.
Article Dans Chinois | WPRIM | ID: wpr-253539

Résumé

<p><b>AIM</b>To study the alkaline-degradation products of ginsenosides from leaves and stems of Panax quinquefolium L.</p><p><b>METHODS</b>Isolation and purification were carried out on silica gel and HPLC; the structures of chemical constituents were elucidated by spectral analysis.</p><p><b>RESULTS</b>From the alkaline-degradation products, nine compounds were identified as: 20 (S) -protopanaxadiol (I), 20 (S) -dammar-25 (26)-ene-3beta, 12beta, 20-triol (II), 24 (R) -ocotillol (III), 20 (S) -protopanaxatriol (IV), 20 (S) -dammar-25 (26)-ene-3beta, 6alpha, 12beta, 20-tetrol (V), dammar-20 (21), 24-diene-3beta, 12beta-diol (VI), dammar-20(21), 24-diene-3beta, 6alpha, 12beta-triol (VII), 20 (S), 24 (S) -dammar-25 (26) -ene-3beta, 6alpha, 12beta, 20, 24-pentanol (VIII), 20 (S) -dammar-23-ene-25-hydroperoxyl-3beta, 6alpha, 12beta, 20-tetrol (IX).</p><p><b>CONCLUSION</b>The configuration of C20 position of ginsenosides was not changed by alkaline-degradation. The complete assignments of 1H and 13C NMR chemical shifts of four new compounds V, VII, VIII, IX, were acquired by means of 2D NMR spectra. Compound I showed antitumor effect on human colon carcinoma cells in vitro.</p>


Sujets)
Humains , Antinéoplasiques d'origine végétale , Pharmacologie , Lignée cellulaire tumorale , Prolifération cellulaire , Tumeurs du côlon , Anatomopathologie , Ginsénosides , Métabolisme , Conformation moléculaire , Structure moléculaire , Panax , Chimie , Feuilles de plante , Chimie , Tiges de plante , Chimie , Plantes médicinales , Chimie , Sapogénines , Chimie , Pharmacologie , Triterpènes , Chimie , Pharmacologie
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