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1.
Article Dans Anglais | IMSEAR | ID: sea-45621

Résumé

Serum hyaluronan (HA) concentration was quantified using an ELISA-based assay with biotinylated hyaluronan binding proteins, and correlated with the clinical and laboratory variables in 100 consecutive rheumatoid arthritis (RA) patients (mean +/- SD age and duration of disease of 50.1 +/- 12.5 and 7.9 +/- 6.6 years respectively). Thirty-four patients received prednisonole at an average dose of 5.0 mg/day. The correlations were good between the serum HA level and the joint swollen scores (r = 0.26, p = 0.04), joint space narrowing scores (r = 0.25, p = 0.03), joint erosion scores (r = 0.26, p = 0.03), and erythrocyte sedimentation rate (r = 0.31, p < 0.01) in RA patients who did not take prednisolone. These correlations were diminished in those who received prednisolone, although their disease was more severe. It might be possible that corticosteroids could decrease inflammation of the joint, thus interfering with the correlations. It was concluded that the serum HA level is a useful marker for the activity and severity of disease in patients with RA.


Sujets)
Adulte , Sujet âgé , Anti-inflammatoires/usage thérapeutique , Polyarthrite rhumatoïde/sang , Test ELISA , Femelle , Humains , Acide hyaluronique/sang , Mâle , Adulte d'âge moyen , Prednisolone/usage thérapeutique , Indice de gravité de la maladie
2.
Asian Pac J Allergy Immunol ; 1999 Jun; 17(2): 77-83
Article Dans Anglais | IMSEAR | ID: sea-36541

Résumé

The outcome of 48 pregnancies from 42 patients with systemic lupus erythematosus was studied. Their mean age and the duration of the disease were 28.47 and 4.42 years, respectively. The conception occurred when the disease was inactive or quiescent in 45 and active in 3. Four pregnancies were terminated by criminal abortion. Flares occurred in 16 pregnancies. The kidney and mucocutaneous system were the 2 organs that flared most commonly. The fetal outcomes were term delivery in 18 (40.90%), prematurity in 17 (38.64%), spontaneous abortion in 6 (13.64%) and still birth in 3 (6.82%). There was no statistical difference in pregnancy loss and successful delivery between pregnant patients with and without flares. Concerning 35 successful live births, those pregnancies without flares had significantly more full term deliveries (p < 0.02), higher gestational age (p < 0.002) and more birth weight (p < 0.001) than those with flares. Small for gestational age was seen in 20%. Pregnancy with active renal disease had a poor fetal outcome. There were no cases of congenital anomalies or neonatal lupus. Maternal complications were more common in patients with flares.


Sujets)
Avortement spontané/étiologie , Adulte , Femelle , Mort foetale/étiologie , Âge gestationnel , Humains , Nourrisson à faible poids de naissance , Nouveau-né , Prématuré , Maladies du rein/complications , Lupus érythémateux disséminé/complications , Grossesse , Complications de la grossesse/étiologie , Issue de la grossesse , Études rétrospectives , Thaïlande
3.
Asian Pac J Allergy Immunol ; 1999 Jun; 17(2): 121-4
Article Dans Anglais | IMSEAR | ID: sea-36998

Résumé

Valvular involvement in patients with systemic lupus erythematosus (SLE) is not uncommon but patients rarely present with it. The mitral valve is most commonly involved. We report a 36-year-old man who had an episode of acute fever, arthritis, and acute aortic insufficiency with a small vegetation at the tip of the aortic valve mimicking infective endocarditis, proven later to be due to SLE. SLE should be considered as one of the uncommon causes of acute aortic insufficiency.


Sujets)
Maladie aigüe , Adulte , Insuffisance aortique/étiologie , Diagnostic différentiel , Fièvre/étiologie , Humains , Lupus érythémateux disséminé/complications , Mâle
4.
Article Dans Anglais | IMSEAR | ID: sea-44792

Résumé

The clinical features and laboratory findings of 91 Thai patients (33 males and 58 females) with CPPD crystal deposition disease were studied. Their average age was 71.54 years. Acute monoarthritis and oligoarthritis were the two most common forms of presentation and were seen in 89 per cent of cases. The knee, wrist and ankle were the three most common joints involved. Associated diseases were common and included hypertension (30 cases), renal insufficiency (23 cases), chronic obstructive pulmonary disease (17 cases), coronary heart disease (13 cases) and diabetes mellitus (12 cases). Eleven patients had malignancies. Five patients had concomitant gout and CPPD crystal deposition disease. The knee and the wrist were the two most common sites of chondrocalcinosis. Of 67 patients who had thyroid function tested, 2 had hyperthyroidism and 5 had hypothyroidism. Hypomagnesemia was seen in 19 per cent. None had hypercalcemia, hypophosphatasia, hemochromatosis or hyperparathyroidism. In contrast to the western series, acute arthritis in our series responded well to oral colchicine alone.


Sujets)
Adulte , Sujet âgé , Sujet âgé de 80 ans ou plus , Chondrocalcinose/complications , Femelle , Humains , Mâle , Adulte d'âge moyen , Études rétrospectives
5.
Article Dans Anglais | IMSEAR | ID: sea-44714

Résumé

Eighty-eight Thai patients (61 males and 27 females) with spondyloarthropathy (SpA) were studied. Their mean age and mean duration of the disease were 25.97 and 3.34 years respectively. In 16 cases the disease first appeared before the age of 16 or had juvenile onset. Eleven cases were ankylosing spondylitis (AS), 9 were juvenile AS (JAS), 20 were Reiter's syndrome (RS), 4 were juvenile RS, 14 were psoriatic arthritis (PsA), 27 were undifferentiated SpA (uSpA), and 3 were juvenile uSpA. Peripheral arthritis, especially oligoarthritis of the lower extremity joints, was the most common form of arthritis in all groups, except for PsA, where polyarthritis was common. Back pain and bilateral sacroiliitis were commonly seen in JAS and AS. Enthesopathy was not uncommon. Extra-articular manifestations were more common in RS patients. Acute inflammatory eye diseases were seen in 45 per cent of AS and 66 per cent of RS cases. In general, the clinical features of Thai patients with SpA were similar to those reported in other countries in Asia and the west.


Sujets)
Adulte , Arthrite psoriasique/diagnostic , Arthrite réactionnelle/diagnostic , Femelle , Humains , Mâle , Maladies du rachis/diagnostic , Pelvispondylite rhumatismale/diagnostic , Thaïlande
6.
Article Dans Anglais | IMSEAR | ID: sea-45317

Résumé

An association between complete congenital heart block (CCHB) and anti-Ro/SSA antibody is well recognized but has never been reported in Thailand. We report here a 37-year-old female who was admitted because of massive epistaxis secondary to immune thrombocytopenia. She had given birth to a child with CCHB 2 years previously, when she was healthy. Antinuclear antibody and anti-Ro/SSA were positive in her sera, but were negative in her son. The relationship between anti-Ro/SSA antibody and outcome of mothers with infants with CCHB is reviewed.


Sujets)
Adulte , Anticorps anti-idiotypiques/immunologie , Anticorps antinucléaires/immunologie , Enfant d'âge préscolaire , Maladies du tissu conjonctif/immunologie , Femelle , Études de suivi , Bloc cardiaque/congénital , Humains , Nourrisson , Nouveau-né , Mâle , Grossesse , Complications de la grossesse/immunologie
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