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1.
Indian J Biochem Biophys ; 1998 Apr; 35(2): 108-14
Article Dans Anglais | IMSEAR | ID: sea-26252

Résumé

Proton magnetic resonance Spectroscopy (PMRS) has been used to study the differences between immortalized fibroblasts and fibrosarcoma cells of different grade. One and two dimensional purged correlation spectroscopy (PCOSY) have been used to assess intact viable fibroblast and fibrosarcoma cells, and differences in the triglyceride, cellular metabolite, and cell surface fucosylation patterns between the three cell lines have been observed. The clinical implication of this study is the potential use of PMRS as an adjunct to conventional histopathology.


Sujets)
Cellules 3T3/cytologie , Acides aminés/métabolisme , Animaux , Cycle cellulaire , Lignée de cellules transformées , Membrane cellulaire/métabolisme , Survie cellulaire , Fibrosarcome/métabolisme , Fucose/analyse , Spectroscopie par résonance magnétique/méthodes , Souris , Phospholipides/métabolisme , Triglycéride/métabolisme , Cellules cancéreuses en culture
2.
Indian J Cancer ; 1992 Sep; 29(3): 139-42
Article Dans Anglais | IMSEAR | ID: sea-50261

Résumé

Twelve patients with high grade osteosarcomas of the extremities were treated with two cycles of induction chemotherapy using adriamycin and cis-platinum and sandwich radiation between the two cycles (4000 rads). Ten patients underwent amputation or disarticulation, two patients had wide excision followed by endoprosthesis. The specimen was assessed for grade of necrosis. The Disease Free Survival at a minimum follow-up period of 26 months and median follow-up period of 35.5%. All the five patients who developed distant metastases had shown only a grade I necrosis in the tumour.


Sujets)
Adolescent , Adulte , Protocoles de polychimiothérapie antinéoplasique/usage thérapeutique , Tumeurs osseuses/traitement médicamenteux , Enfant , Cisplatine/administration et posologie , Association thérapeutique , Doxorubicine/administration et posologie , Femelle , Humains , Mâle , Ostéosarcome/traitement médicamenteux , Projets pilotes
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