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Indian J Dermatol Venereol Leprol ; 2014 Mar-Apr; 80(2): 129-133
Article Dans Anglais | IMSEAR | ID: sea-154763

Résumé

Background/Objective: Extramammary Paget’s Disease (EMPD) seems to be more common in Caucasians than Chinese. We report the clinical manifestations, management, and prognostic characteristics in 17 Chinese patients. Methods: Medical records and biopsies of 17 patients who had been treated at a large university hospital in China between March 2005 and January 2012 were reviewed. Results: Of the 17 patients, 14 were men. They had lesions on the scrotum and the penis. Of the three women, two had vulvar and one had inguinal lesions. All patients underwent Mohs micrographic surgery (MMS). Three men had metastasis to the inguinal lymph nodes and underwent an extensive local excision with inguinal lymphadenectomy. Eight patients who had positive excision margins received additional radiation therapy. The mean follow-up duration was 54 months (4-85 months). One patient had two recurrences. Three had metastasis to the inguinal lymph node. One had metastasis to the bone and concomitant prostate cancer. Two patients died of the disease. Conclusion: A striking difference in presentation of EMPD in Chinese compared with Caucasians is the male predominance and location on the penis and scrotum. Mohs micrographic surgery followed by radiotherapy is an effective treatment. Long-term follow-up suggests that the disease has a good prognosis when it does not metastasise.


Sujets)
Adulte , Sujet âgé , Asiatiques , Association thérapeutique , Femelle , Études de suivi , Tumeurs de l'appareil génital féminin/anatomopathologie , Tumeurs de l'appareil génital féminin/radiothérapie , Tumeurs de l'appareil génital féminin/chirurgie , Tumeurs de l'appareil génital mâle/anatomopathologie , Tumeurs de l'appareil génital mâle/radiothérapie , Tumeurs de l'appareil génital mâle/chirurgie , Humains , Lymphadénectomie , Mâle , Adulte d'âge moyen , Chirurgie de Mohs , Maladie de Paget extramammaire/anatomopathologie , Maladie de Paget extramammaire/radiothérapie , Maladie de Paget extramammaire/chirurgie , Pénis/anatomopathologie , Pénis/chirurgie , Pronostic , Scrotum/anatomopathologie , Scrotum/chirurgie , Résultat thérapeutique , Vulve/anatomopathologie , Vulve/chirurgie
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