Corrigendum to “Long-term consumption of virgin coconut (Cocos nucifera) oil diet impairs learning and memory in CD1 mice” Chinese Herbal Medicines 12 (2020) 414–420 (Chinese Herbal Medicines (2020) 12(4) (414–420), (S1674638420300770), (10.1016/j.chmed.2020.03.008)) / 中草药·英文版

When this paper was first published the following ethical statement was omitted in error: All animal experiments followed the guidelines established by the Institutional Animal Ethical Committee of University of Calabar, Nigeria. The authors would like to apologise for any inconvenience caused.

Long-term consumption of virgin coconut (Cocos nucifera) oil diet impairs learning and memory in CD1 mice / 中草药·英文版

Objective: Virgin coconut oil (VCO) has been used in the management of dementia in Alzheimer's disease (AD). Therefore, this research investigated the effect of long-term consumption of VCO diet on learning and memory in CD1 mice. Methods: Thirty male CD1 mice (divided into three groups, n = 10) were fed with standard rodent chow (control), 5% and 20% VCO diets (respectively) for 28 d. The Morris Water Maze (MWM) test was used to test the effect of VCO on visuo-spatial learning and memory, while the Novel Object Recognition Test (NORT) was used to measure short- and long-term recognition memory. Results: Learning performance of mice did not differ in the MWM. During the probe trial, duration in the retention quadrant and annulus crossings were lower (P 0.05). The discrimination index was also lower in the 20% VCO group compared to control and 5% VCO diet groups indicating impaired long-term cognitive memory in mice given 20% VCO diet. Histological examination of brains showed damage within the CA1 pyramidal cell layer of the hippocampus in the 20% VCO diet group, in line with the behavioural observations. Conclusion: Long-term consumption of virgin coconut oil diet impairs memory in mice.