A Case of Diffuse Leukoencephalopathy Caused by 5-Fluorouracil Derivatives

A stomach cancer patient is reported, who presented with asterixis and dysarthria, after the administration of 5-fluorouracil derivatives, and progressed to a state of arnnesia and disorientation. At first impression was metastatic brain tumor however7 the result of a cerebrospinal fluid cytology for malignancy was negative, and magnetic resonance imaging study(MRI) revealed diffuse hyperintense lesion of the white matter, indicative of leukoencephalopathy. Upon discontinuing the drugs, patient recovered significantly.lly predominant muscle weakness from distal myopathy with rimmed vacuole formation While we present a young female.