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Pulmonary Arteriovenous Malformations (PAVM) are abnormal fistulous connections between a pulmonary artery and a pulmonary vein that generate a right-to-left shunt by avoiding the normal pulmonary capillary bed. We report an unusual case of a young female patient who presented to the department of Obstetrics and Gynaecology with Bleeding per vagina diagnosed as Failed intrauterine pregnancy; Unilateral pedal edema and Breathlessness. Pulmonary Thromboembolism was suspected and Computed Tomography pulmonary angiogram (CTPA) was advised for, which showed abnormal communication between dilated left main pulmonary artery and dilated tortuous superior pulmonary vein. Multiple adjacent solid and ground glass nodules were also noticed which were suggestive of initial telangiectatic state of PAVMs. Most of PAVMs are related to Hereditary Hemorrhagic Telangiectasia, whereas only 10 to 20% are isolated sporadic cases. Pregnancy has been considered as a precipitant factor for PAVMs in most of the cases, patients and pregnant women affected by PAVMs are asymptomatic, but when the clinical manifestations occur, they are often related to the right-to-left shunting and may include dyspnoea, hypoxia, and pulmonary hypertension. Moreover, presence of one or multiple PAVMs during pregnancy is associated with an increased risk of severe complications such as rupture, haemothorax, and hypovolemic shock. Hence this case reports highlights the necessity for the radiologists to think in terms of PAVM as a differential diagnosis beyond the suspicion of Pulmonary thromboembolism to look for any abnormal arteria venous communication while reporting CTPA in pregnant women with breathlessness and foresee the catastrophic complications in an already known case of PAVM during pregnancy. Also, the radiologists should identify subtle solid or ground-glass nodules adjacent to large PAVMS which are the initial telangiectatic stage of PAVMs.
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Background: Detecting congenital heart disease (CHD) early is crucial for better outcomes, but most newborns show no symptoms. Newborn screening for CHD can identify such cases preventing serious consequences. This study aims to determine CHD prevalence and evaluate the effectiveness of pulse oximeter screening and clinical examination, correlating them with echocardiography findings.Methods: A cross-sectional study was conducted to screen for CHD in all newborns born in our institution over a period of 3 months. A sample of 660 newborns were screened by pulse oximeter screening and clinical examination after random sampling.Results: Comparison of baseline data like age distribution in mothers, gender and gestational age were comparable between newborns with CHD and those without CHD. A total of 8 CHDs were picked up after screening 660 newborns screened during a period of 3 months. CHDs that were picked up included hypoplastic left heart syndrome, pulmonary atresia, bicuspid aortic valve, transposition of great arteries, coarctation of the aorta, and other complex CHDs. It was found that either clinical examination or pulse oximeter screening has higher sensitivity than pulse oximetry screening or clinical examination alone.Conclusions: For identification of a CHD in newborns after 24 hours of birth the order of preference for screening based on sensitivity is as follows-either pulse oximeter screening or clinical examination >clinical examination >pulse oximeter screening >pulse oximeter screening and clinical examination.
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Background: Multi-parameter monitoring devices are essential for providing real-time patient data, which is crucial for effective healthcare interventions. This clinical trial evaluated the accuracy of the ProRithm beat-to-beat cuffless device for arterial blood pressure monitoring, comparing it with a standard sphygmomanometer. Methods: This observational study included 30 subjects aged 18 and above. Systolic and diastolic blood pressure measurements from both the ProRithm device and the Philips Monitor were compared using statistical analysis. Results: The analysis revealed no statistically significant differences between the ProRithm device and the manual method. In comparison with manual measurements using a sphygmomanometer, the mean systolic blood pressure was 131.2 mmHg with ProRithm it was 129.3 mmHg. Similarly, with the manual method, while the mean diastolic blood pressure was 76.2 mmHg and with ProRithm it was 75.9 mmHg. Conclusions: This study indicates that portable, small-sized devices like ProRithm, which facilitate remote monitoring, are effective for real-time blood pressure assessment in clinical settings.
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Neurofibromatosis type-1 is an autosomal dominant tumour syndrome with a high clinical susceptibility to malignancies, especially nervous system malignancies. Here, we reported a case of neurofibromatosis type-1 in a male in his 50s, who presented with generalised weakness, headache associated with ear pain, a feeling of heaviness of the head, and giddiness for a duration of 1 week. On examination, he had axillary freckling and multiple neurofibromas over his body. Nystagmus and dysdiadokokinesia were present. MRI brain revealed an enhancing lesion in the sphenoid and clivus, extending into the sellar and supra-sellar region. The possibility of pituitary adenoma and clival chordoma were considered. He was referred to Neurosurgery and underwent Trans-nasal Trans-sphenoidal near-total resection of the tumour. Biopsy of the lesion was indicative of conventional clival chordoma, which is rarely reported with NF-1. The post-operative period was uneventful and the patient is planned for regular follow-up to detect recurrence.
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Background: Electronic waste, or e-waste, refers to all items of electrical and electronic equipment (EEE) and its parts that have been discarded by its owner as waste without the intent of re-use. Improper e-waste management can lead to adverse human health effects and environmental pollution. The aim of our study was to assess the knowledge, attitude and practice regarding e-waste management and the factors affecting it. Methods: This cross-sectional study was conducted from December 2023 to February 2024 in three block panchayats of Malappuram district in Kerala with a sample size of 266 selected using multistage sampling. Data was entered in Microsoft Office and was analysed using statistical package for the social sciences (SPSS) software. Factors affecting the outcome variables was assessed using Chi-square test or Fisher exact test depending on the sample distribution. Results: Study results showed that 28.9% of the participants had good awareness, 27.1% had average awareness and 44% of the population had poor awareness and on e-waste management. 89.5% of population had a very good perception towards e waste management. Age, gender, type of family they come from, educational factors, occupational factors and socioeconomic class were the factors affecting e-waste management. Conclusions: Increasing public awareness and educating stakeholders about the hazards of e-waste is crucial. Promotion of campaigns and programs to inform individuals about the proper disposal methods, recycling options, and the importance of reducing e-waste generation through responsible consumption can significantly improve the management of e-waste.
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Background: Ventilator associated pneumonia (VAP) is very common in pediatric intensive care unit (PICU) intubated patients and also responsible for major morbidity and mortality. Usually, it develops after 48 hours of mechanically ventilated patients, its incidence increases as the duration of time increases and it is a major risk factor for VAP. The present study was carried out to know the overall incidence of VAP in mechanically ventilated patients in PICU.Methods: The study was carried out in PICU of the department of pediatrics, B. R. D. Medical College, Gorakhpur from October 2020 to October 2021. Patients aged between 1 year to 15 years were included in the study.Results: There were 50 (59.5%) patients� male and 34 (40.5%) patients� female under investigation. The clinical pulmonary infection score (CPIS) values ranged from the mean value of 4.38�30 at 36th hours to 7.33�92 at 96th hours of intubation. VAP was present in 23 (27.3%) patients while 62 (73.8%) patients were having no VAP. Among VAP associated patients, 14.3% were Acinetobacter positive, 5.95% were Klebsiella positive and 3.57% were E. coli positive.Conclusions: Parameters of CPIS associated with VAP revealed that Acinetobactor was comparative more common organism and the age group of 1 to 5 years was more sensitive. VAP can be reduced by decreasing the duration of mechanical ventilation.
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Background: The present study aimed to analyse clinical and biochemical profile among children admitted with diabetic ketoacidosis (DKA) and their correlation in prognosis of children admitted in PICU.Methods: The prospective study was conducted in pediatric intensive care unit (PICU) of RNT medical college, Udaipur among 50 DKA children in the age group of (1 month-18 years) for a period of one year after approval of institutional ethics committee. In the study, HbA1c level was measured by automated analyzer method to find out the past 3-month duration of glycemic control. Pearson correlation coefficient was used to find the correlation between serum osmolality and GCS, serum osmolality and duration of hospital stay, correlation between HbA1c levels and GCS, HbA1c levels and duration of hospital stay.Result: The most common presenting complaint was respiratory distress (72%) followed by vomiting (54%), polyuria (34%), polydipsia (24%), pain in abdomen (24%), fever (24%) and polyphagia (4%). There was negative correlation between HbA1c and depressed sensorium, i.e. patients with higher HbA1c levels had poor GCS and it was statistically significant. Patients with higher HbA1c levels had longer duration of hospital stay, although this observation was not statistically significant. Conclusions: The present study concluded that patients presenting with DKA had severe derangement in acid-base parameters. The DKA patients who had higher serum osmolality and poor glycemic control had depressed sensorium at the time of hospital admission and a longer recovery time leading to a prolonged hospital stay, adding to the morbidity associated with the disease.
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The term lithopedion was derived from the Greek words Lithos and Pedion. It is a rare ectopic pregnancy with incidence as low as 1.5-2.0% of all ectopics. An 80-year old female patient presented to the orthopaedic out-patient department with complaints of lower back pain and mild lower abdominal pain, no history of any trauma. The patient was a known case of Ttype II diabetes and hypertension on medication, no other comorbidities. The patient was referred to the department of radio-diagnosis, for plain radiograph of the lumbo-sacral spine, antero-posterior and lateral view for further evaluation. The plain radiograph revealed a well-defined oval shaped radio-density in the pelvis more towards the right side. Further evaluation was done in the form of ultrasound abdomen and computed tomography. Computed tomography revealed a mummified fetus which is in close proximity to the internal organs and adhering to bowel loop. Low socioeconomic status combined with lack of education of the population are the primary causes for delay in diagnosis resulting in undiagnosed ectopic pregnancy and its later transformation into a Lithopedion.
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Coronary Artery Disease (CAD) is a prevalent cardiovascular illness that is a primary cause of morbidity and mortality globally. It is distinguished by the constriction or blockage of the coronary arteries, which limits blood circulation to the heart. Inflammation is a driving force in the pathophysiology of CAD. Colchicine is an anti-inflammatory medication that has lately been studied for its potential application in the treatment of CAD. Its multimodal method of action has sparked interest due to its ability to treat inflammation and lower the concentration of critical inflammatory biomarkers. Clinical evidence validates the safe and effective use of Colchicine in CAD. Several recommendations advocate the use of colchicine in the secondary prevention of CAD. This article discusses the use of low-dose colchicine in CAD, its function in inflammation, as well as its safety and therapeutic effectiveness.
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Background: Exclusive breastfeeding is vital for maternal and child health, yet challenges persist. This study in a Kerala tertiary care hospital aimed to assess prevalence, identify barriers, and explore cultural influences. Aim was to determine the prevalence of exclusive breastfeeding, uncover the barriers mothers face, and explore cultural factors affecting infant feeding choices.Methods: Utilizing Google forms, 274 postpartum women were surveyed. Participants provided data on awareness, practices, challenges, and factors influencing their infant feeding choices.Results: While 94.9% were aware of the ideal breastfeeding duration, only 74.1% practised exclusive breastfeeding until six months. Inadequate breast milk, sore nipples, and family pressure emerged as challenges. The timing of solid food introduction significantly impacted exclusive breastfeeding.Conclusions: Our study offers insights into exclusive breastfeeding practices. Culturally sensitive interventions, comprehensive support systems, and healthcare provider engagement are crucial. This study echoes recent research, emphasizing the multifaceted nature of exclusive breastfeeding practices, calling for diverse and context-specific strategies to empower mothers and ensure infants receive the best nutritional start.
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Background: Fortification plays a vital role in supporting the nutritional requirements in the premature infants. Currently in India, fortifiers are either whole protein based or whey protein which are bovine milk- based, which has been associated with increased risk of feed intolerance and necrotizing enterocolitis (NEC), to circumvent this, an amino-acids based fortifier has been made available which provides more proteins (0.35 g/1 g sachet) thereby meeting the nutritional requirements of preterm infants. Aim was to study effect (safety and efficacy) of fortification with the amino-acids based fortifier (HMF-ADVANCE, Analeptik Biologicals) in premature infants admitted in the neonatal intensive care unit (NICU).Methods: A single centre pilot study was conducted on preterm infants with <1800 g birth weight and/or <32 gestational age, amino-acids based fortifier (AABF) was used as the fortification option once the infants reached 100 ml/kg/day feed volume. 1 g of HMF-ADVANCE was mixed in 25 ml of mother抯 own milk (MOM) and the fortification was continued till discharge from NICU.Results: A total 100 preterm infants were included for the study, mean gestational age (GA) was 29.38�61 weeks, mean birth weight was 1159.90�1.9. Growth outcomes at the end of the study: mean weight gain was 23.73�62 g/day, mean head circumference gain was 1.02�41 cm/week, mean length gain was 1.01�15 cm/week and weight gain velocity were 17.13�38 g/kg/day. Blood urea nitrogen (BUN) showed an increasing trend from baseline (before starting fortification: 3.2 mg/dl), 1 week after fortification (6.3 mg/dl) and at the end of study (11.2 mg/dl). AABF was also used in three neonates post NEC. There were no episodes of feed intolerance or necrotising enterocolitis episodes and none of neonates discontinued fortification till discharge from NICU.Conclusions: AABF was well tolerated without any feed intolerance episodes and helped to achieve optimal growth. AABF can be the optimal choice of fortification in low-birth-weight neonates.
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Eclipta prostrata Linn. is an annual herbaceous plant used in traditional medicine, commonly known as "Trailing Eclipta" or False Daisy in English, ' Keekirindiya ' in Sinhala and ' Kayyantakara' in Tamil. The aim of this study was to conduct a detailed pharmacognostical evaluation of E. prostrata found in Sri Lanka. Anatomical, physicochemical, phytochemical studies, and quantification of phyto - constituents were performed as per WHO guidelines. Whole plant was sequ entially extracted into solvents with different polarities. Phytochemical screening and Thin Layer Chromatography (TLC) fingerprinting were carried out. Anatomical study and powder microscopy revealed useful diagnostic features. Physicochemical parameters such as moisture content, ash values (total, acid insoluble, water soluble) and extractable matter in water and ethanol were evaluated. Phytochemical screening and TLC fingerprinting revealed the presence of different types of phyto - constituents. Alkaloid, tannin, saponin, total flavonoid and total polyphenol contents were quantified. In conclusion, pharmacognostical study aids in establishing the standardization parameters of E. prostrata found in Sri Lanka.
Eclipta prostrata Linn. es una planta herbácea anual utilizada en la medicina tradicional, comúnmente conocida como "Trailing Eclipta" o False Daisy en inglés, 'Keekirindiya' en sinhala y 'Kayyan takara' en tamil. El objetivo de este estudio fue realizar una evaluación farmacognóstica detallada de E. prostrata encontrada en Sri Lanka. Se llevaron a cabo estudios anatómicos, fisicoquímicos, fitoquímicos y cuantificación de fitoconstituyentes según l as directrices de la OMS. Se extrajo secuencialmente la planta entera en solventes con diferentes polaridades. Se realizaron pruebas de tamizaje fitoquímico y huellas dactilares de cromatografía en capa delgada (TLC). El estudio anatómico y la microscopía en polvo revelaron características diagnósticas útiles. Se evaluaron parámetros fisicoquímicos como el contenido de humedad, los valores de ceniza (total, insoluble en ácido, soluble en agua) y la materia extraíble en agua y etanol. Las pruebas de tamizaje fitoquímico y las huellas dactilares de TLC revelaron la presencia de diferentes tipos de fitoconstituyentes. Se cuantificaron los contenidos de alcaloides, taninos, saponinas, flavonoides totales y polifenoles totales. En conclusión, el estudio farmacogn óstico ayuda a establecer los parámetros de estandarización de E. prostrata encontrada en Sri Lanka.
Sujet(s)
Eclipta/composition chimique , Saponines/analyse , Sri Lanka , Flavonoïdes/analyse , Chromatographie sur couche mince , Eclipta/anatomie et histologie , Polyphénols/analyseRÉSUMÉ
Aims@#This study investigates the community structure and diversity of terrestrial soil bacterial communities thriving in four contrasting Köppen climatic zones of India using high-throughput sequencing.@*Methodology and results@#Soil samples were collected for metagenomic DNA isolation and PCR amplification using primers targeting the 16S rRNA gene region. Amplicons were subjected to Oxford nanopore sequencing and data analysis. Bacterial species diversity, evenness and richness were highest in a humid sub-tropical climatic zone (HSCZ). Firmicutes were the most abundant phylum in the tropical wet climatic zone (TWCZ), arid climatic zone (ACZ) and humid sub-tropical climatic zone (HSCZ), while Proteobacteria in the mountain climatic zone (MCZ). The predominance of class Alphaproteobacteria, Actinobacteria with genera Bradyrhizobium, Chthoniobacter and Mycobacterium, was observed in MCZ in contrast to class Bacilli with genera Bacillus and Paenibacillus in the rest of the zones. OTU abundance was positively correlated with moisture, TOC (total organic carbon), K, MAP (mean annual precipitation) and negatively correlated with pH, Ca, N, B, Fe, P, Mg and MAT (mean annual temperature). A significant correlation was only observed with Fe against Shannon diversity (H’) in multiple regression analysis. @*Conclusion, significance and impact of study@#The multidirectional relationship between soil, its microbiota and climate is crucial in modulating bacterial community diversity and its survival in terrestrial ecosystems that significantly contribute to ecosystem function. This work mapped the occurrence and distribution of terrestrial soil bacterial communities in contrasting climatic zones for the first time, enabling us to assess the effect of climate in the mentioned Köppen climatic zones.
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Methods@#In total, 108 patients who underwent surgery for traumatic LLFs between January 2010 and January 2020 were reviewed to obtain their demographic details, injury level, and neurology status at the time of presentation (American Spinal Injury Association [ASIA] grade). Preoperative computed tomography scans were used to measure parameters such as anterior vertebral body height, posterior vertebral body height, loss of vertebral body height, local kyphosis, retropulsion of fracture fragment, interpedicular distance, canal compromise, sagittal transverse ratio, and presence of vertical lamina fracture. MRI was used to measure the canal encroachment ratio (CER), cross-sectional area of the thecal sac (CSAT), and presence of an epidural hematoma. @*Results@#Of the 108 patients, 9 (8.3%) had ASIA A, 4 (3.7%) had ASIA B, 17 (15.7%) had ASIA C, 21 (19.4%) had ASIA D, and 57 (52.9%) had ASIA E neurology upon admission. The Thoracolumbar Injury Classification and Severity score (p =0.000), CER (p =0.050), and CSAT (p =0.019) were found to be independently associated with neurological deficits on the multivariate analysis. The receiver operating characteristic curves showed that only CER (area under the curve [AUC], 0.926; 95% confidence interval [CI], 0.860–0.968) and CSAT (AUC, 0.963; 95% CI, 0.908–0.990) had good discriminatory ability, with the optimal cutoff of 50% and 65.3 mm2, respectively. @*Conclusions@#Based on the results, the optimal cutoff values of CER >50% and CSAT >65.3 mm2 can predict the incidence of neurological deficits in LLFs.
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Background/Aims@#The pancreatic pseudocyst (PP) is a type of fluid collection that typically develops as a delayed complication of acute pancreatitis. Drainage is indicated for symptomatic patients and/or associated complications, such as infection and bleeding. Drainage modalities include percutaneous, endoscopic, laparoscopic, and open drainage. This study aimed to assess trends in the utilization of different drainage modalities for treating PP from 2016 to 2020. The trends in mortality, mean length of hospital stay, and mean hospitalization costs were also assessed. @*Methods@#The National Inpatient Sample database was used to obtain data. The variables were generated using International Classification of Diseases-10 diagnostic and procedural codes. @*Results@#Endoscopic drainage was the most commonly used drainage modality in 2018–2020, with an increasing trend over time (385 procedures in 2018 to 515 in 2020; p=0.003). This is associated with a decrease in the use of other drainage modalities. A decrease in the hospitalization cost for PP requiring drainage was also noted (29,318 United States dollar [USD] in 2016 to 18,087 USD in 2020, p<0.001). @*Conclusions@#Endoscopic drainage is becoming the most commonly used modality for the treatment of PP in hospitals located in the US. This new trend is associated with decreasing hospitalization costs.
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Background/Aims@#Nonagenarians will purportedly account for 10% of the United States population by 2050. However, no studies have assessed the outcomes of nonvariceal upper gastrointestinal bleeding (NVUGIB) in this age group. @*Methods@#The National Inpatient Sample database between 2016 and 2020 was used to compare the clinical outcomes of NVUGIB in nonagenarians and octogenarians and evaluate predictors of mortality and the use of esophagogastroduodenoscopy (EGD). @*Results@#Nonagenarians had higher in-hospital mortality than that of octogenarians (4% vs. 3%, p<0.001). EGD utilization (30% vs. 48%, p<0.001) and blood transfusion (27% vs. 40%, p<0.001) was significantly lower in nonagenarians. Multivariate logistic regression analysis revealed that nonagenarians with NVUGIB had higher odds of mortality (odds ratio [OR], 1.5; 95% confidence interval [CI], 1.3–1.7) and lower odds of EGD utilization (OR, 0.86; 95% CI, 0.83–0.89) than those of octogenarians. @*Conclusions@#Nonagenarians admitted with NVUGIB have a higher mortality risk than that of octogenarians. EGD is used significantly in managing NVUGIB among nonagenarians; however, its utilization is comparatively lower than in octogenarians. More studies are needed to assess predictors of poor outcomes and the indications of EGD in this growing population.
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Median arcuate ligament syndrome (MALS) is a rare condition and a diagnosis of exclusion.We present a 30-year-old man, who had postprandial upper abdominal pain and weight loss of 6 kg in 3 months. His gastroscopy and abdominal ultrasound results were both unremarkable.Computed tomographic angiography showed characteristic compression of the celiac arteryby thickened median arcuate ligament causing a ‘J’ shaped course of artery with poststenoticdilatation and dilated branches of the celiac artery. The patient underwent laparoscopic release of the median arcuate ligament. The intraoperative blood loss was 20 mL and duration of the procedure was 140 minutes. The patient had an uneventful recovery and was discharged on postoperative day 2. The symptoms subsided 2 months following surgery and he started gaining weight. Laparoscopic division of the median arcuate ligament is a minimally invasive, safe, and effective method to decompress the celiac artery.
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Background@#Wistar rats are extensively used as the model for assessing toxicity and efficacy in preclinical research.Hematological and biochemical laboratory data are essential for evaluating specific variations in the physiological and functional profile of a laboratory animal. Establishing hematological and biochemical reference values for Wistar (han) rats at various age intervals was the goal of this work. Male and female Wistar rats (n = 660) of ages 6–8 weeks, 10–14 weeks and > 6 months were used in the experiment. Blood and serum were collected from these rats under fasting conditions. @*Results@#We observed that the majority of hematological and biochemical parameters were significantly influenced by sex and age. Hematological changes were significantly correlated to aging were increased red blood cells, hemoglobin, hematocrit, neutrophils, monocytes and eosinophils in both sexes, as well as decreased platelet, mean corpuscular volume, mean corpuscular hemoglobin and lymphocytes in both sexes. White blood cells of male rats were considerably higher than those of female rats in all age ranges. For biochemistry, increase in glucose, total protein and creatinine were seen in both sexes, along with increases in urea in females and alanine aminotransferase in males.Age was significantly associated with decreased alkaline phosphatase in both sexes. @*Conclusions@#When using Wistar rats as a model, these reference values may be useful in evaluating the results.
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SUMMARY OBJECTIVE: Tumor budding is a phenomenon in which the tumor cells detach from the main mass and are present at the invasive front. The present study was conducted to study tumor budding in invasive breast carcinoma and to correlate it with clinicopathological parameters and molecular subtypes. METHODS: The study was conducted over a period of 1 year, and tumor budding was studied as a single or group of cells at the invasive front of breast carcinoma counted in a high-power field (40×). The grading was statistically correlated with tumor size, grade, lymph node status, lymphovascular invasion, pathological TNM staging, molecular subtype, and survival of patients. RESULTS: A total of 50 cases of invasive breast carcinoma were included, out of which 66% (n=33) showed high-grade tumor budding, which was statistically significantly higher in grade 2 invasive ductal carcinoma (p<0.05). High tumor budding was associated with lymphovascular invasion, lymph node metastasis, and a high Ki-67 proliferative index. All cases showing low-grade budding were alive until 6 months of diagnosis, but there was no statistically significant association between stage and budding. CONCLUSION: Tumor buds are significantly higher in grade 2 invasive ductal carcinoma with lymphovascular invasion, lymph node metastasis, and a high Ki-67 proliferative index. Immunohistochemistry may prove helpful in distinguishing tumor buds from their mimickers. Further studies with extended follow-up are recommended to predict tumor budding as a prognostic marker in breast carcinoma, which may play an important role in cancer therapy.
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Background:Clinical and evidence-based information is very important in the field of clinical sciences including speech and hearing sciences. More and More professionals are resorting to published articles for knowledge on assessment and intervention that are evidence based. Therefore, there is a need of standard evaluation methods for each type of research that is published. The aim of the study is to investigate the quality of the cohort research articles by using the assessment tool Q-coh and thereby checking the reliability of the assessment tool. Methods:The tool Q-coh developed by Jarde etal with the aim to screen the methodological quality of the primary studies with a cohort design was taken for quality assessment of cohort research articles. Q-Coh consists of 26 items and 7 inferences. Assessment was carried out by few reviewers who were blinded to the classification of quality and based on the evaluation received from the reviewers the quality of the articles were determined. Agreement analysis was done to check the proportion of agreement between the raters and reliability of the tool respectively. Results:The research findings indicate that there is a fair to substantial agreement between the raters. Further, the quality of the articles was determined and classified into the class of acceptable and good quality. Conclusions: The present study was conducted to check if the checklist Q-cohis applicable to assess the methodological quality of cohort research studies. The outcomes of the study indicate that the tool is reliable.